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  <doc>
    <id>7958</id>
    <completedYear/>
    <publishedYear>2021</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>1538</pageFirst>
    <pageLast>1541</pageLast>
    <pageNumber/>
    <edition/>
    <issue>7</issue>
    <volume>46</volume>
    <type>article</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
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    <title language="eng">Quantitative spectroscopy of single molecule interaction times</title>
    <abstract language="eng">Single molecule fluorescence tracking provides information at nanometer-scale and millisecond-temporal resolution about the dynamics and interaction of individual molecules in a biological environment. While the dynamic behavior of isolated molecules can be characterized well, the quantitative insight is more limited when interactions between two indistinguishable molecules occur. We address this aspect by developing a theoretical foundation for a spectroscopy of interaction times, i.e., the inference of interaction from imaging data. A non-trivial crossover between a power law to an exponential behavior of the distribution of the interaction times is highlighted, together with the dependence of the exponential term upon the microscopic reaction affinity. Our approach is validated with simulated and experimental datasets.</abstract>
    <parentTitle language="eng">Optic Letters</parentTitle>
    <identifier type="doi">10.1364/OL.413030</identifier>
    <enrichment key="PeerReviewed">yes</enrichment>
    <author>Horst-Holger Boltz</author>
    <submitter>Kalina Tsankova</submitter>
    <author>Alexei Sirbu</author>
    <author>Nina Stelzer</author>
    <author>Martin J. Lohse</author>
    <author>Christof Schütte</author>
    <author>Paolo Annibale</author>
    <collection role="institutes" number="num">Numerical Mathematics</collection>
    <collection role="persons" number="schuette">Schütte, Christof</collection>
    <collection role="projects" number="MathPlusAA1-1">MathPlusAA1-1</collection>
    <collection role="institutes" number="MfLMS">Mathematics for Life and Materials Science</collection>
    <collection role="institutes" number="MSoCP">Modeling and Simulation of Complex Processes</collection>
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