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  <doc>
    <id>7504</id>
    <completedYear/>
    <publishedYear/>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume/>
    <type>reportzib</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>2019-11-12</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">A pharmacokinetic-pharmacodynamic model for single dose administration of Dexamethasone in dairy cows</title>
    <abstract language="eng">We present a mechanistic pharmacokinetic-pharmacodynamic model to simulate the effect of dexamethasone on the glucose metabolism in dairy cows.&#13;
The coupling of the pharmacokinetic model to the pharmacodynamic model&#13;
is based on mechanisms underlying homeostasis regulation by dexamethasone.&#13;
In particular, the coupling takes into account the predominant role of dexamethasone in stimulating glucagon secretion, glycogenolysis and lipolysis and in&#13;
impairing the sensitivity of cells to insulin. Simulating the effect of a single&#13;
dose of dexamethasone on the physiological behaviour of the system shows that&#13;
the adopted mechanisms are able to induce a temporary hyperglycemia and&#13;
hyperinsulinemia, which captures the observed data in non-lactating cows. In&#13;
lactating cows, the model simulations show that a single dose of dexamethasone&#13;
reduces the lipolytic effect, owing to the reduction of glucose uptake by the&#13;
mammary gland.</abstract>
    <identifier type="issn">1438-0064</identifier>
    <identifier type="urn">urn:nbn:de:0297-zib-75043</identifier>
    <author>Mohamed Omari</author>
    <submitter>Mohamed Omari</submitter>
    <author>Julia Plöntzke</author>
    <author>Susanna Röblitz</author>
    <series>
      <title>ZIB-Report</title>
      <number>19-53</number>
    </series>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>systems biology; modelling; differential equations; metabolism; nutrition; bovine; fertility; reproduction; hormones; follicles; Dexamethasone; PK-PD</value>
    </subject>
    <collection role="institutes" number="num">Numerical Mathematics</collection>
    <collection role="institutes" number="compsys">Computational Systems Biology</collection>
    <collection role="persons" number="susanna.roeblitz">Röblitz, Susanna</collection>
    <collection role="projects" number="BovSys">BovSys</collection>
    <collection role="persons" number="omari">Omari, Mohamed</collection>
    <file>https://opus4.kobv.de/opus4-zib/files/7504/MetRep_Dexamethasone_Adm_ZIB_Report.pdf</file>
  </doc>
</export-example>
