3496
2007
2007
eng
19
32
4360
conferenceobject
Springer
0
--
--
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Accelerated microRNA-Precursor Detection Using the Smith-Waterman Algorithm on FPGAs
GCCB
Lecture Notes in Bioinformatics
Patrick May
W. Dubitzky
Gunnar Klau
Markus Bauer
Thomas Steinke
Distributed Algorithms and Supercomputing
Steinke, Thomas
938
eng
reportzib
0
2006-10-18
2006-10-18
--
A computational approach to microRNA detection
During the last few years more and more functionalities of RNA have been discovered that were previously thought of being carried out by proteins alone. One of the most striking discoveries was the de tection of microRNAs, a class of noncoding RNAs that play an important role in post-transcriptional gene regulation. Large-scale analyses are needed for the still increasingly growing amount of sequen ce data derived from new experimental technologies. In this paper we present a framework for the detection of the distinctive precursor structure of microRNAS that is based on the well-known Smith-Wat erman algorithm and various filtering steps. We conducted experiments on real genomic data and we found several new putative hits for microRNA precursor structures.
06-44
938
urn:nbn:de:0297-zib-9383
Patrick May
Markus Bauer
Christian Köberle
Gunnar Klau
ZIB-Report
06-44
eng
uncontrolled
microRNA Smith-Waterman RNA folding
Informatik, Informationswissenschaft, allgemeine Werke
LIFE AND MEDICAL SCIENCES
Computational methods
Protein sequences, DNA sequences
Distributed Algorithms and Supercomputing
https://opus4.kobv.de/opus4-zib/files/938/ZR-06-44.pdf