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<export-example>
  <doc>
    <id>7975</id>
    <completedYear/>
    <publishedYear>2021</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume>12</volume>
    <type>article</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2021-03-11</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Mathematical Modelling and Simulation Provides Evidence for New Strategies of Ovarian Stimulation</title>
    <abstract language="eng">New approaches to ovarian stimulation protocols, such as luteal start, random start or double stimulation, allow for flexibility in ovarian stimulation at different phases of the menstrual cycle which is especially useful when time for assisted reproductive technology is limited, e.g. for emergency fertility preservation in cancer patients.&#13;
It has been proposed that the success of these methods is based on the continuous growth of multiple cohorts ("waves") of follicles throughout the menstrual cycle which leads to the availability of ovarian follicles for ovarian controlled stimulation at several time points. Though several preliminary studies have been published, their scientific evidence has not been considered as being strong enough to integrate these results into routine clinical practice. This work aims at adding further scientific evidence about the efficiency of variable-start protocols and underpinning the theory of follicular waves by using mathematical modelling and numerical simulations. For this purpose, we have modified and coupled two previously published models, one describing the time course of hormones and one describing competitive follicular growth in a normal menstrual cycle. The coupled model is used to test stimulation protocols in silico. Simulation results show the occurrence of follicles in a wave-like manner during a normal menstrual cycle and qualitatively predict the outcome of ovarian stimulation initiated at different time points of the menstrual cycle.</abstract>
    <parentTitle language="eng">Frontiers in Endocrinology</parentTitle>
    <identifier type="doi">10.3389/fendo.2021.613048</identifier>
    <enrichment key="PeerReviewed">yes</enrichment>
    <enrichment key="AcceptedDate">2021-01-26</enrichment>
    <author>Sophie Fischer</author>
    <submitter>Rainald Ehrig</submitter>
    <author>Rainald Ehrig</author>
    <author>Stefan Schäfer</author>
    <author>Enrico Tronci</author>
    <author>Toni Mancini</author>
    <author>Marcel Egli</author>
    <author>Fabian Ille</author>
    <author>Tillmann H. C. Krüger</author>
    <author>Brigitte Leeners</author>
    <author>Susanna Röblitz</author>
    <collection role="institutes" number="num">Numerical Mathematics</collection>
    <collection role="institutes" number="compsys">Computational Systems Biology</collection>
    <collection role="persons" number="ehrig">Ehrig, Rainald</collection>
    <collection role="projects" number="PAEON">PAEON</collection>
    <collection role="institutes" number="MSoCP">Modeling and Simulation of Complex Processes</collection>
  </doc>
  <doc>
    <id>5584</id>
    <completedYear/>
    <publishedYear>2016</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume/>
    <type>conferenceobject</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">An integrative approach for model driven computation of treatments in reproductive medicine</title>
    <parentTitle language="eng">BIOMAT - Proceedings of the 15th International Symposium on Mathematical and Computational Biology, Rorkee, India</parentTitle>
    <enrichment key="PeerReviewed">yes</enrichment>
    <enrichment key="PreprintUrn">urn:nbn:de:0297-zib-57103</enrichment>
    <author>Rainald Ehrig</author>
    <submitter>Mascha Berg</submitter>
    <author>Thomas Dierkes</author>
    <author>Stefan Schäfer</author>
    <author>Susanna Röblitz</author>
    <author>Enrico Tronci</author>
    <author>Toni Mancini</author>
    <author>Ivano Salvo</author>
    <author>Vadim Alimguzhin</author>
    <author>Federico Mari</author>
    <author>Igor Melatti</author>
    <author>Annalisa Massini</author>
    <author>Tillmann H. C. Krüger</author>
    <author>Marcel Egli</author>
    <author>Fabian Ille</author>
    <author>Brigitte Leeners</author>
    <collection role="institutes" number="num">Numerical Mathematics</collection>
    <collection role="institutes" number="compsys">Computational Systems Biology</collection>
    <collection role="persons" number="ehrig">Ehrig, Rainald</collection>
    <collection role="persons" number="susanna.roeblitz">Röblitz, Susanna</collection>
    <collection role="projects" number="PAEON">PAEON</collection>
  </doc>
  <doc>
    <id>5163</id>
    <completedYear/>
    <publishedYear>2014</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>207</pageFirst>
    <pageLast>214</pageLast>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume/>
    <type>conferenceobject</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Patient-Specific Models from Inter-Patient Biological Models and Clinical Records</title>
    <parentTitle language="eng">Proceedings of the 14th Conference on Formal Methods in Computer-Aided Design (FMCAD 2014)</parentTitle>
    <enrichment key="PeerReviewed">yes</enrichment>
    <author>Toni Mancini</author>
    <submitter> Stötzel</submitter>
    <author>Ivano Salvo</author>
    <author>Federico Mari</author>
    <author>Igor Melatti</author>
    <author>Annalisa Massini</author>
    <author>Stefano Sinisi</author>
    <author>Enrico Tronci</author>
    <author>Francesco Davi</author>
    <author>Thomas Dierkes</author>
    <author>Rainald Ehrig</author>
    <author>Susanna Röblitz</author>
    <author>Brigitte Leeners</author>
    <author>Tillmann H. C. Krüger</author>
    <author>Marcel Egli</author>
    <author>Fabian Ille</author>
    <collection role="institutes" number="num">Numerical Mathematics</collection>
    <collection role="institutes" number="compsys">Computational Systems Biology</collection>
    <collection role="persons" number="ehrig">Ehrig, Rainald</collection>
    <collection role="persons" number="susanna.roeblitz">Röblitz, Susanna</collection>
    <collection role="projects" number="PAEON">PAEON</collection>
  </doc>
  <doc>
    <id>6429</id>
    <completedYear/>
    <publishedYear>2017</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>21</pageFirst>
    <pageLast>27</pageLast>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume>99</volume>
    <type>article</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Negative affect is unrelated to fluctuations in hormone levels across the menstrual cycle: evidence from a multisite observational study across two successive cycles</title>
    <parentTitle language="eng">Journal of Psychosomatic Research</parentTitle>
    <identifier type="doi">10.1016/j.jpsychores.2017.05.018</identifier>
    <enrichment key="PeerReviewed">yes</enrichment>
    <author>Michael Hengartner</author>
    <submitter>Rainald Ehrig</submitter>
    <author>Tillmann H. C. Krüger</author>
    <author>Kirsten Geraedts</author>
    <author>Enrico Tronci</author>
    <author>Toni Mancini</author>
    <author>Fabian Ille</author>
    <author>Marcel Egli</author>
    <author>Susanna Röblitz</author>
    <author>Rainald Ehrig</author>
    <author>Lanja Saleh</author>
    <author>Katharina Spanaus</author>
    <author>Cordula Schippert</author>
    <author>Yuanyuan Zhang</author>
    <author>Brigitte Leeners</author>
    <collection role="institutes" number="num">Numerical Mathematics</collection>
    <collection role="institutes" number="compsys">Computational Systems Biology</collection>
    <collection role="persons" number="ehrig">Ehrig, Rainald</collection>
    <collection role="persons" number="susanna.roeblitz">Röblitz, Susanna</collection>
    <collection role="projects" number="PAEON">PAEON</collection>
  </doc>
  <doc>
    <id>5710</id>
    <completedYear/>
    <publishedYear/>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume/>
    <type>reportzib</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>2016-01-20</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">An Integrative Approach for Model Driven Computation of Treatments in Reproductive Medicine</title>
    <abstract language="eng">We present an overview of the current status of the European collaborative&#13;
project PAEON. The challenge of PAEON is to provide specialists in reproduc-&#13;
tive medicine with a computerised model of the menstrual cycle under normal&#13;
and various pathological conditions, which will allow them to get further in-&#13;
sight in fertility dynamics. This model also enables the simulation of treatment&#13;
protocols, which were used within in vitro fertilization. By the definition of&#13;
virtual patients through biologically admissible parametrizations our approach&#13;
allows not only the evaluation of a given treatment strategy in silico, but also&#13;
the design and optimization of such protocols. Once a protocol is formalized&#13;
in the virtual hospital, the success can be controlled by a treatment execution&#13;
monitor, which works then as a clinical decision support system. All these tools&#13;
will be combined in a virtual hospital environment, enabling the access to the&#13;
PAEON services through the web.</abstract>
    <identifier type="issn">1438-0064</identifier>
    <identifier type="urn">urn:nbn:de:0297-zib-57103</identifier>
    <enrichment key="SourceTitle">Appeared in: 15th International Symposium on Mathematical and Computational Biology, Rorkee, India</enrichment>
    <author>Rainald Ehrig</author>
    <submitter>Mascha Berg</submitter>
    <author>Thomas Dierkes</author>
    <author>Stefan Schäfer</author>
    <author>Susanna Röblitz</author>
    <author>Enrico Tronci</author>
    <author>Toni Mancini</author>
    <author>Ivano Salvo</author>
    <author>Vadim Alimguzhin</author>
    <author>Federico Mari</author>
    <author>Igor Melatti</author>
    <author>Annalisa Massini</author>
    <author>Tillmann H. C. Krüger</author>
    <author>Marcel Egli</author>
    <author>Fabian Ille</author>
    <author>Brigitte Leeners</author>
    <series>
      <title>ZIB-Report</title>
      <number>16-04</number>
    </series>
    <collection role="institutes" number="num">Numerical Mathematics</collection>
    <collection role="institutes" number="compsys">Computational Systems Biology</collection>
    <collection role="persons" number="ehrig">Ehrig, Rainald</collection>
    <collection role="persons" number="susanna.roeblitz">Röblitz, Susanna</collection>
    <collection role="projects" number="PAEON">PAEON</collection>
    <file>https://opus4.kobv.de/opus4-zib/files/5710/Ehrig_et_al.pdf</file>
  </doc>
</export-example>
