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  <doc>
    <id>7792</id>
    <completedYear/>
    <publishedYear>2020</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>e50988</pageFirst>
    <pageLast/>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume>9</volume>
    <type>article</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Sperm-specific meiotic chromosome segregation in C. elegans</title>
    <parentTitle language="eng">eLife</parentTitle>
    <identifier type="doi">10.7554/eLife.50988</identifier>
    <enrichment key="PeerReviewed">yes</enrichment>
    <enrichment key="AcceptedDate">2020-03-08</enrichment>
    <author>Gunar Fabig</author>
    <submitter>Steffen Prohaska</submitter>
    <author>Robert Kiewisz</author>
    <author>Norbert Lindow</author>
    <author>James A. Powers</author>
    <author>Vanessa Cota</author>
    <author>Luis J. Quintanilla</author>
    <author>Jan Brugués</author>
    <author>Steffen Prohaska</author>
    <author>Diana S. Chu</author>
    <author>Thomas Müller-Reichert</author>
    <collection role="institutes" number="vis">Visual Data Analysis</collection>
    <collection role="institutes" number="vissys">Image Analysis in Biology and Materials Science</collection>
    <collection role="persons" number="norbert.lindow">Lindow, Norbert</collection>
    <collection role="persons" number="prohaska">Prohaska, Steffen</collection>
    <collection role="projects" number="SPINDLE">SPINDLE</collection>
    <collection role="institutes" number="VDcC">Visual and Data-centric Computing</collection>
  </doc>
  <doc>
    <id>6417</id>
    <completedYear>2017</completedYear>
    <publishedYear>2017</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber/>
    <edition/>
    <issue>15288</issue>
    <volume>8</volume>
    <type>article</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2017-05-11</completedDate>
    <publishedDate>2017-05-11</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">C. elegans chromosomes connect to centrosomes by anchoring into the spindle network</title>
    <abstract language="eng">The mitotic spindle ensures the faithful segregation of chromosomes. Here we combine the first large-scale serial electron tomography of whole mitotic spindles in early C. elegans embryos with live-cell imaging to reconstruct all microtubules in 3D and identify their plus- and minus-ends. We classify them as kinetochore (KMTs), spindle (SMTs) or astral microtubules (AMTs) according to their positions, and quantify distinct properties of each class. While our light microscopy and mutant studies show that microtubules are nucleated from the centrosomes, we find only a few KMTs directly connected to the centrosomes. Indeed, by quantitatively analysing several models of microtubule growth, we conclude that minus-ends of KMTs have selectively detached and depolymerized from the centrosome. In toto, our results show that the connection between centrosomes and chromosomes is mediated by an anchoring into the entire spindle network and that any direct connections through KMTs are few and likely very transient.</abstract>
    <parentTitle language="eng">Nature Communications</parentTitle>
    <identifier type="doi">10.1038/ncomms15288</identifier>
    <enrichment key="PeerReviewed">yes</enrichment>
    <author>Stefanie Redemann</author>
    <submitter>Norbert Lindow</submitter>
    <author>Johannes Baumgart</author>
    <author>Norbert Lindow</author>
    <author>Michael Shelley</author>
    <author>Ehssan Nazockdast</author>
    <author>Andrea Kratz</author>
    <author>Steffen Prohaska</author>
    <author>Jan Brugués</author>
    <author>Sebastian Fürthauer</author>
    <author>Thomas Müller-Reichert</author>
    <collection role="institutes" number="vis">Visual Data Analysis</collection>
    <collection role="persons" number="kratz">Kratz, Andrea</collection>
    <collection role="persons" number="norbert.lindow">Lindow, Norbert</collection>
    <collection role="persons" number="prohaska">Prohaska, Steffen</collection>
    <collection role="projects" number="SPINDLE">SPINDLE</collection>
    <collection role="institutes" number="VDcC">Visual and Data-centric Computing</collection>
  </doc>
</export-example>
