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<export-example>
  <doc>
    <id>1774</id>
    <completedYear/>
    <publishedYear/>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume/>
    <type>reportzib</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2013-02-14</completedDate>
    <publishedDate>2013-02-14</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Modeling potassium balance in dairy cows</title>
    <abstract language="eng">Potassium is fundamental for cell functioning including signal transduction, acid-base- and water-metabolism. &#13;
Since diet of dairy cows is generally rich in potassium, hypokalemia was not in the focus of research for long time. Furthermore, hypokalemia was not frequently diagnosed because blood potassium content is difficult to measure. In recent years, measurement methods have been improved. Nowadays hypokalemia is increasingly diagnosed in cows with disorders such as abomasal displacement, ketosis or down cow syndrome, calling for intensified research on this topic. &#13;
In this report we describe the development of a basic mechanistic, dynamic model of potassium balance based on ordinary differential and algebraic equations. Parameter values are obtained from data of a clinical trial in which potassium balance and the influence of therapeutic intervention in glucose and electrolyte metabolism on potassium balance in non-lactating dairy cows were studied. The model is formulated at a high abstraction level and includes information and hypotheses from literature. This work represents a first step towards the understanding and design of effective prophylactic feed additives and treatment strategies.</abstract>
    <identifier type="issn">1438-0064</identifier>
    <identifier type="urn">urn:nbn:de:0297-zib-17749</identifier>
    <author>Julia Plöntzke</author>
    <submitter>Julia Ploentzke</submitter>
    <author>Mascha Berg</author>
    <author>Amiya Olany</author>
    <author>Sabine Leonhard-Marek</author>
    <author>Kerstin-Elisabeth Müller</author>
    <author>Susanna Röblitz</author>
    <series>
      <title>ZIB-Report</title>
      <number>13-09</number>
    </series>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>systems biology</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>differential equations</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>metabolism</value>
    </subject>
    <collection role="msc" number="92C30">Physiology (general)</collection>
    <collection role="msc" number="92C42">Systems biology, networks</collection>
    <collection role="institutes" number="num">Numerical Mathematics</collection>
    <collection role="institutes" number="compsys">Computational Systems Biology</collection>
    <collection role="persons" number="susanna.roeblitz">Röblitz, Susanna</collection>
    <collection role="projects" number="BovSys">BovSys</collection>
    <file>https://opus4.kobv.de/opus4-zib/files/1774/ZR-13-09.pdf</file>
  </doc>
  <doc>
    <id>7294</id>
    <completedYear/>
    <publishedYear>2022</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume>12, 19781</volume>
    <type>article</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2022-10-17</completedDate>
    <publishedDate>2022-10-17</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Model Based Exploration of Hypokalemia in Dairy Cows</title>
    <abstract language="eng">Hypokalemia, characterized by too low serum potassium levels, is a severe mineral disorder which can be life threatening. It is increasingly diagnosed in veterinarian healthcare and a topic of ongoing research. In this paper, we explore the different originating conditions of hypokalemia: reduced potassium intake, increased excretion, acid-base disturbances, or increased insulin, by using a dynamic mathematical model for potassium balance in non-lactating and lactating cows.&#13;
Simulations are compared with literature. The results give insights into the network dynamics and point to scenarios on which experimental effort should be focused. Application of mathematical models can assist in experimental planning as well as the reduction, refinement and replacement of animal experiments.</abstract>
    <parentTitle language="eng">Scientific Reports</parentTitle>
    <identifier type="doi">10.1038/s41598-022-22596-0</identifier>
    <enrichment key="PeerReviewed">yes</enrichment>
    <enrichment key="AcceptedDate">2022/10/17</enrichment>
    <author>Julia Plöntzke</author>
    <submitter>Rainald Ehrig</submitter>
    <author>Mascha Berg</author>
    <author>Rainald Ehrig</author>
    <author>Sabine Leonhard-Marek</author>
    <author>Kerstin-Elisabeth Müller</author>
    <author>Susanna Röblitz</author>
    <collection role="institutes" number="compsys">Computational Systems Biology</collection>
    <collection role="persons" number="ehrig">Ehrig, Rainald</collection>
    <collection role="persons" number="susanna.roeblitz">Röblitz, Susanna</collection>
    <collection role="projects" number="BovSys">BovSys</collection>
    <collection role="institutes" number="MSoCP">Modeling and Simulation of Complex Processes</collection>
  </doc>
  <doc>
    <id>7207</id>
    <completedYear/>
    <publishedYear>2018</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>226</pageFirst>
    <pageLast>227</pageLast>
    <pageNumber>2</pageNumber>
    <edition>Journal of Dairy Science</edition>
    <issue/>
    <volume>101 Suppl. 2</volume>
    <type>proceedings</type>
    <publisherName>American Dairy Science Association</publisherName>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">A mathematical modelling approach to the insight of dynamic networks: Potassium homeostasis and glucose-insulin in dairy cows</title>
    <abstract language="eng">Lactating dairy cows require a particular composition of nutritional ingredients depending on their production status. &#13;
The optimal supply of energy and minerals in diet, one of them potassium, is indispensable for the prevention of disbalances like hypokalemia or hypoglycaemia.&#13;
Potassium balance in cows is the result of potassium intake, distribution in the organism, and excretion, and closely interacts with glucose and electrolyte metabolism, in which postpartum veterinary treatments frequently intervene.&#13;
We present a mechanistic, dynamic model for potassium balance together with a glucose insulin model in non-lactating and lactating dairy cows based on ordinary differential equations.   &#13;
Parameter values were obtained from data of a clinical trial as well as from literature. To verify the mechanistic functioning of the model, we validate the model by comparing simulation outcomes with clinical study findings. Furthermore we perform numerical experiments and compare them with expected behaviour according to mechanistic knowledge. The results give insight into the dynamic behaviour of the network and open the way for further open questions and hypothesis to be tested.</abstract>
    <parentTitle language="eng">ADSA 2018 Annual Meeting</parentTitle>
    <identifier type="url">https://www.adsa.org/Portals/0/SiteContent/Docs/Meetings/PastMeetings/Annual/2018/223.pdf</identifier>
    <enrichment key="PeerReviewed">yes</enrichment>
    <submitter>Julia Plöntzke</submitter>
    <author>Julia Plöntzke</author>
    <author>Mascha Berg</author>
    <author>Susanna Röblitz</author>
    <collection role="institutes" number="num">Numerical Mathematics</collection>
    <collection role="persons" number="susanna.roeblitz">Röblitz, Susanna</collection>
    <collection role="projects" number="BovSys">BovSys</collection>
  </doc>
  <doc>
    <id>6093</id>
    <completedYear/>
    <publishedYear>2016</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume/>
    <type>poster</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Modelling of glucose-insulin metabolism and its effect on the estrous cycle in bovine</title>
    <parentTitle language="eng">Annual Meeting of the Population Approach Group in Europe</parentTitle>
    <enrichment key="PeerReviewed">yes</enrichment>
    <author>Mohamed Omari</author>
    <submitter> Lange</submitter>
    <author>Julia Plöntzke</author>
    <author>Mascha Berg</author>
    <author>Susanna Röblitz</author>
    <collection role="institutes" number="num">Numerical Mathematics</collection>
    <collection role="institutes" number="compsys">Computational Systems Biology</collection>
    <collection role="persons" number="susanna.roeblitz">Röblitz, Susanna</collection>
    <collection role="projects" number="BovSys">BovSys</collection>
    <collection role="persons" number="omari">Omari, Mohamed</collection>
  </doc>
  <doc>
    <id>5585</id>
    <completedYear/>
    <publishedYear>2015</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume/>
    <type>conferenceobject</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">A systems biology approach to bovine fertility and metabolism: Introduction of a glucose insulin model</title>
    <parentTitle language="eng">15th International Symposium on Mathematical and Computational Biology, Rorkee, India</parentTitle>
    <enrichment key="PeerReviewed">yes</enrichment>
    <enrichment key="PreprintUrn">urn:nbn:de:0297-zib-56453</enrichment>
    <author>Julia Plöntzke</author>
    <submitter>Mascha Berg</submitter>
    <author>Mascha Berg</author>
    <author>Claudia Stötzel</author>
    <author>Susanna Röblitz</author>
    <collection role="institutes" number="num">Numerical Mathematics</collection>
    <collection role="institutes" number="compsys">Computational Systems Biology</collection>
    <collection role="persons" number="susanna.roeblitz">Röblitz, Susanna</collection>
    <collection role="projects" number="BovSys">BovSys</collection>
  </doc>
  <doc>
    <id>6475</id>
    <completedYear/>
    <publishedYear/>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume/>
    <type>reportzib</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>2017-08-17</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">A dynamic model to simulate potassium balance in dairy cows.</title>
    <abstract language="eng">High performing dairy cows require a particular composition of nutritional ingredients, adapted to their individual requirements and depending on their production status. The optimal dimensioning of minerals in the diet, one of them being potassium, is indispensable for the prevention of imbalances. The potassium balance in cows is the result of potassium intake, distribution in the organism, and excretion, it is closely related with the glucose and electrolyte metabolism. In this paper, we present a dynamical model for the potassium balance in lactating and non-lactating dairy cows based on ordinary differential equations. Parameter values are obtained from clinical trial data and from the literature. To verify the consistency of the model, we present simulation outcomes for three different scenarios: potassium balance in (i) non-lactating cows with varying feed intake, (ii) non-lactating cows with varying potassium fraction in the diet, and (iii) lactating cows with varying milk production levels. The results give insights into the short and long term potassium metabolism, providing an important step towards the understanding of the potassium network, the design of prophylactic feed additives, and possible treatment strategies.</abstract>
    <identifier type="issn">1438-0064</identifier>
    <identifier type="urn">urn:nbn:de:0297-zib-64756</identifier>
    <identifier type="doi">10.3168/jds.2016-12443</identifier>
    <enrichment key="SourceTitle">Appeared in: Journal of Dairy Science 2017</enrichment>
    <author>Mascha Berg</author>
    <submitter>Julia Plöntzke</submitter>
    <author>Julia Plöntzke</author>
    <author>Sabine Leonhard-Marek</author>
    <author>Kerstin-Elisabeth Müller</author>
    <author>Susanna Röblitz</author>
    <series>
      <title>ZIB-Report</title>
      <number>17-47</number>
    </series>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>cow, potassium, model, ode</value>
    </subject>
    <collection role="ccs" number="J.">Computer Applications</collection>
    <collection role="msc" number="34-XX">ORDINARY DIFFERENTIAL EQUATIONS</collection>
    <collection role="msc" number="92-XX">BIOLOGY AND OTHER NATURAL SCIENCES</collection>
    <collection role="institutes" number="num">Numerical Mathematics</collection>
    <collection role="persons" number="susanna.roeblitz">Röblitz, Susanna</collection>
    <collection role="projects" number="BovSys">BovSys</collection>
    <file>https://opus4.kobv.de/opus4-zib/files/6475/ZR-17-47.pdf</file>
  </doc>
  <doc>
    <id>5645</id>
    <completedYear/>
    <publishedYear/>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume/>
    <type>reportzib</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>2015-10-30</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">A systems biology approach to bovine fertility and metabolism: Development of a glucose insulin model.</title>
    <abstract language="eng">To counteract the antagonistic relationship between milk yield and fertility in dairy cow, a&#13;
deeper understanding of the underlying biological mechanisms is required. For this purpose,&#13;
we study physiological networks related to reproduction and metabolism in dairy cows. We&#13;
interactively develop dynamic, mechanistic models by fitting the models to experimental data&#13;
and mechanistic knowledge. We have already developed models for potassium balance and&#13;
hormonal regulation of fertility in the dairy cow, which will briefly be reviewed here. The main&#13;
focus of this article is a glucose-insulin model currently developed by us. This model links the&#13;
bovine hormonal cycle and the potassium balance to glucose and thus to energy metabolism.&#13;
The models can be applied in scientific research, education, experimental planning, drug&#13;
development and production on farms.</abstract>
    <identifier type="issn">1438-0064</identifier>
    <identifier type="urn">urn:nbn:de:0297-zib-56453</identifier>
    <enrichment key="SourceTitle">appeared in 15th International Symposium on Mathematical and Computational Biology, Rorkee, India</enrichment>
    <author>Julia Plöntzke</author>
    <submitter>Mascha Berg</submitter>
    <author>Mascha Berg</author>
    <author>Claudia Stötzel</author>
    <author>Susanna Röblitz</author>
    <series>
      <title>ZIB-Report</title>
      <number>15-51</number>
    </series>
    <collection role="institutes" number="num">Numerical Mathematics</collection>
    <collection role="institutes" number="compsys">Computational Systems Biology</collection>
    <collection role="persons" number="susanna.roeblitz">Röblitz, Susanna</collection>
    <collection role="projects" number="BovSys">BovSys</collection>
    <file>https://opus4.kobv.de/opus4-zib/files/5645/ZR_glucose_lay.pdf</file>
  </doc>
  <doc>
    <id>6529</id>
    <completedYear/>
    <publishedYear>2017</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>9799</pageFirst>
    <pageLast>9814</pageLast>
    <pageNumber/>
    <edition/>
    <issue>12</issue>
    <volume>100</volume>
    <type>article</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">A dynamic model to simulate potassium balance in dairy cows</title>
    <abstract language="eng">High-performing dairy cows require a particular composition of nutritional ingredients, adapted to their individual requirements and depending on their production status. The optimal dimensioning of minerals in the diet, one being potassium, is indispensable for the prevention of imbalances. Potassium balance in cows is the result of potassium intake, distribution in the organism, and excretion, and it is closely related to glucose and electrolyte metabolism. In this paper, we present a dynamical model for potassium balance in lactating and nonlactating dairy cows based on ordinary differential equations. Parameter values were obtained from clinical trial data and from the literature. To verify the consistency of the model, we present simulation outcomes for 3 different scenarios: potassium balance in (1) nonlactating cows with varying feed intake, (2) nonlactating cows with varying potassium fraction in the diet, and (3) lactating cows with varying milk production levels. The results give insights into the short- and long-term potassium metabolism, providing an important step toward the understanding of the potassium network, the design of prophylactic feed additives, and possible treatment strategies.</abstract>
    <parentTitle language="eng">Journal of Dairy Science</parentTitle>
    <identifier type="doi">10.3168/jds.2016-12443</identifier>
    <enrichment key="PeerReviewed">yes</enrichment>
    <enrichment key="PreprintUrn">urn:nbn:de:0297-zib-64756</enrichment>
    <author>Mascha Berg</author>
    <submitter>Julia Plöntzke</submitter>
    <author>Julia Plöntzke</author>
    <author>Sabine Leonhard-Marek</author>
    <author>Kerstin-Elisabeth Müller</author>
    <author>Susanna Röblitz</author>
    <collection role="institutes" number="num">Numerical Mathematics</collection>
    <collection role="institutes" number="compsys">Computational Systems Biology</collection>
    <collection role="persons" number="susanna.roeblitz">Röblitz, Susanna</collection>
    <collection role="projects" number="BovSys">BovSys</collection>
  </doc>
  <doc>
    <id>8589</id>
    <completedYear/>
    <publishedYear>2021</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>1</pageFirst>
    <pageLast>25</pageLast>
    <pageNumber/>
    <edition/>
    <issue>121</issue>
    <volume>83</volume>
    <type>article</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Modelling Oscillatory Patterns in the Bovine Estrous Cycle with Boolean Delay Equations</title>
    <abstract language="eng">Boolean delay equations (BDEs), with their relatively simple and intuitive mode of&#13;
modelling, have been used in many research areas including, for example, climate&#13;
dynamics and earthquake propagation. Their application to biological systems has been&#13;
scarce and limited to the molecular level. Here, we derive and present two BDE models.&#13;
One is directly derived from a previously published ordinary differential equation&#13;
(ODE) model for the bovine estrous cycle, whereas the second model includes a&#13;
modification of a particular biological mechanism. We not only compare the simulation&#13;
results from the BDE models with the trajectories of the ODE model, but also validate&#13;
the BDE models with two additional numerical experiments. One experiment induces&#13;
a switch in the oscillatory pattern upon changes in the model parameters, and the&#13;
other simulates the administration of a hormone that is known to shift the estrous&#13;
cycle in time. The models presented here are the first BDE models for hormonal&#13;
oscillators, and the first BDE models for drug administration. Even though automatic&#13;
parameter estimation still remains challenging, our results support the role of BDEs&#13;
as a framework for the systematic modelling of complex biological oscillators.</abstract>
    <parentTitle language="eng">Bulletin of Mathematical Biology</parentTitle>
    <identifier type="doi">10.1007/s11538-021-00942-z</identifier>
    <enrichment key="AcceptedDate">2021-09-08</enrichment>
    <enrichment key="opus.source">publish</enrichment>
    <enrichment key="PeerReviewed">yes</enrichment>
    <author>Mascha Berg</author>
    <submitter>Stefanie Winkelmann</submitter>
    <author>Julia Plöntzke</author>
    <author>Heike Siebert</author>
    <author>Susanna Röblitz</author>
    <collection role="persons" number="susanna.roeblitz">Röblitz, Susanna</collection>
    <collection role="projects" number="BovSys">BovSys</collection>
    <collection role="institutes" number="MSoCP">Modeling and Simulation of Complex Processes</collection>
  </doc>
</export-example>
