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  <doc>
    <id>8724</id>
    <completedYear/>
    <publishedYear>2022</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber/>
    <edition/>
    <issue>5</issue>
    <volume>25</volume>
    <type>article</type>
    <publisherName>Cell Press</publisherName>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Linking digital surveillance and in-depth virology to study clinical patterns of viral respiratory infections in vulnerable patient populations</title>
    <abstract language="eng">To improve the identification and management of viral respiratory infections, we established a clinical and virologic surveillance program for pediatric patients fulfilling pre-defined case criteria of influenza-like illness and viral respiratory infections. The program resulted in a cohort comprising 6,073 patients (56% male, median age 1.6 years, range 0–18.8 years), where every patient was assessed with a validated disease severity score at the point-of-care using the ViVI ScoreApp. We used machine learning and agnostic feature selection to identify characteristic clinical patterns. We tested all patients for human adenoviruses, 571 (9%) were positive. Adenovirus infections were particularly common and mild in children ≥1 month of age but rare and potentially severe in neonates: with lower airway involvement, disseminated disease, and a 50% mortality rate (n = 2/4). In one fatal case, we discovered a novel virus …</abstract>
    <parentTitle language="eng">iScience</parentTitle>
    <identifier type="doi">10.1016/j.isci.2022.104276</identifier>
    <enrichment key="PeerReviewed">yes</enrichment>
    <enrichment key="opus.source">publish</enrichment>
    <author>Patrick E Obermeier</author>
    <submitter>Tim Conrad</submitter>
    <author>Albert Heim</author>
    <author>Barbara Biere</author>
    <author>Elias Hage</author>
    <author>Maren Alchikh</author>
    <author>Tim Conrad</author>
    <author>Brunhilde Schweiger</author>
    <author>Barbara A Rath</author>
    <collection role="persons" number="conrad">Conrad, Tim</collection>
    <collection role="projects" number="MODAL-MedLab">MODAL-MedLab</collection>
    <collection role="projects" number="MODAL-Gesamt">MODAL-Gesamt</collection>
    <collection role="institutes" number="VDcC">Visual and Data-centric Computing</collection>
  </doc>
</export-example>
