@inproceedings{vonTycowicz2020, author = {von Tycowicz, Christoph}, title = {Towards Shape-based Knee Osteoarthritis Classification using Graph Convolutional Networks}, booktitle = {2020 IEEE 17th International Symposium on Biomedical Imaging (ISBI 2020)}, arxiv = {http://arxiv.org/abs/1910.06119}, doi = {10.1109/ISBI45749.2020.9098687}, year = {2020}, abstract = {We present a transductive learning approach for morphometric osteophyte grading based on geometric deep learning. We formulate the grading task as semi-supervised node classification problem on a graph embedded in shape space. To account for the high-dimensionality and non-Euclidean structure of shape space we employ a combination of an intrinsic dimension reduction together with a graph convolutional neural network. We demonstrate the performance of our derived classifier in comparisons to an alternative extrinsic approach.}, language = {en} } @inproceedings{HanikHegeHennemuthetal.2020, author = {Hanik, Martin and Hege, Hans-Christian and Hennemuth, Anja and von Tycowicz, Christoph}, title = {Nonlinear Regression on Manifolds for Shape Analysis using Intrinsic B{\´e}zier Splines}, booktitle = {Proc. Medical Image Computing and Computer Assisted Intervention (MICCAI)}, publisher = {Springer International Publishing}, address = {Cham}, arxiv = {http://arxiv.org/abs/2007.05275}, doi = {10.1007/978-3-030-59719-1_60}, pages = {617 -- 626}, year = {2020}, abstract = {Intrinsic and parametric regression models are of high interest for the statistical analysis of manifold-valued data such as images and shapes. The standard linear ansatz has been generalized to geodesic regression on manifolds making it possible to analyze dependencies of random variables that spread along generalized straight lines. Nevertheless, in some scenarios, the evolution of the data cannot be modeled adequately by a geodesic. We present a framework for nonlinear regression on manifolds by considering Riemannian splines, whose segments are B{\´e}zier curves, as trajectories. Unlike variational formulations that require time-discretization, we take a constructive approach that provides efficient and exact evaluation by virtue of the generalized de Casteljau algorithm. We validate our method in experiments on the reconstruction of periodic motion of the mitral valve as well as the analysis of femoral shape changes during the course of osteoarthritis, endorsing B{\´e}zier spline regression as an effective and flexible tool for manifold-valued regression.}, language = {en} } @inproceedings{HanikHegevonTycowicz2020, author = {Hanik, Martin and Hege, Hans-Christian and von Tycowicz, Christoph}, title = {Bi-invariant Two-Sample Tests in Lie Groups for Shape Analysis}, booktitle = {Shape in Medical Imaging}, publisher = {Springer International Publishing}, address = {Cham}, arxiv = {http://arxiv.org/abs/2008.12195}, doi = {10.1007/978-3-030-61056-2_4}, pages = {44 -- 54}, year = {2020}, abstract = {We propose generalizations of the T²-statistics of Hotelling and the Bhattacharayya distance for data taking values in Lie groups. A key feature of the derived measures is that they are compatible with the group structure even for manifolds that do not admit any bi-invariant metric. This property, e.g., assures analysis that does not depend on the reference shape, thus, preventing bias due to arbitrary choices thereof. Furthermore, the generalizations agree with the common definitions for the special case of flat vector spaces guaranteeing consistency. Employing a permutation test setup, we further obtain nonparametric, two-sample testing procedures that themselves are bi-invariant and consistent. We validate our method in group tests revealing significant differences in hippocampal shape between individuals with mild cognitive impairment and normal controls.}, language = {en} } @inproceedings{AmbellanZachowvonTycowicz2019, author = {Ambellan, Felix and Zachow, Stefan and von Tycowicz, Christoph}, title = {An as-invariant-as-possible GL+(3)-based Statistical Shape Model}, volume = {11846}, booktitle = {Proc. 7th MICCAI workshop on Mathematical Foundations of Computational Anatomy (MFCA)}, publisher = {Springer}, doi = {10.1007/978-3-030-33226-6_23}, pages = {219 -- 228}, year = {2019}, abstract = {We describe a novel nonlinear statistical shape model basedon differential coordinates viewed as elements of GL+(3). We adopt an as-invariant-as possible framework comprising a bi-invariant Lie group mean and a tangent principal component analysis based on a unique GL+(3)-left-invariant, O(3)-right-invariant metric. Contrary to earlier work that equips the coordinates with a specifically constructed group structure, our method employs the inherent geometric structure of the group-valued data and therefore features an improved statistical power in identifying shape differences. We demonstrate this in experiments on two anatomical datasets including comparison to the standard Euclidean as well as recent state-of-the-art nonlinear approaches to statistical shape modeling.}, language = {en} } @inproceedings{AmbellanZachowvonTycowicz2019, author = {Ambellan, Felix and Zachow, Stefan and von Tycowicz, Christoph}, title = {A Surface-Theoretic Approach for Statistical Shape Modeling}, volume = {11767}, booktitle = {Proc. Medical Image Computing and Computer Assisted Intervention (MICCAI), Part IV}, publisher = {Springer}, doi = {10.1007/978-3-030-32251-9_3}, pages = {21 -- 29}, year = {2019}, abstract = {We present a novel approach for nonlinear statistical shape modeling that is invariant under Euclidean motion and thus alignment-free. By analyzing metric distortion and curvature of shapes as elements of Lie groups in a consistent Riemannian setting, we construct a framework that reliably handles large deformations. Due to the explicit character of Lie group operations, our non-Euclidean method is very efficient allowing for fast and numerically robust processing. This facilitates Riemannian analysis of large shape populations accessible through longitudinal and multi-site imaging studies providing increased statistical power. We evaluate the performance of our model w.r.t. shape-based classification of pathological malformations of the human knee and show that it outperforms the standard Euclidean as well as a recent nonlinear approach especially in presence of sparse training data. To provide insight into the model's ability of capturing natural biological shape variability, we carry out an analysis of specificity and generalization ability.}, language = {en} } @inproceedings{HanikHegevonTycowicz2022, author = {Hanik, Martin and Hege, Hans-Christian and von Tycowicz, Christoph}, title = {A Nonlinear Hierarchical Model for Longitudinal Data on Manifolds}, booktitle = {2022 IEEE 19th International Symposium on Biomedical Imaging (ISBI)}, arxiv = {http://arxiv.org/abs/2202.01180}, doi = {10.1109/ISBI52829.2022.9761465}, pages = {1 -- 5}, year = {2022}, abstract = {Large longitudinal studies provide lots of valuable information, especially in medical applications. A problem which must be taken care of in order to utilize their full potential is that of correlation between intra-subject measurements taken at different times. For data in Euclidean space this can be done with hierarchical models, that is, models that consider intra-subject and between-subject variability in two different stages. Nevertheless, data from medical studies often takes values in nonlinear manifolds. Here, as a first step, geodesic hierarchical models have been developed that generalize the linear ansatz by assuming that time-induced intra-subject variations occur along a generalized straight line in the manifold. However, this is often not the case (e.g., periodic motion or processes with saturation). We propose a hierarchical model for manifold-valued data that extends this to include trends along higher-order curves, namely B{\´e}zier splines in the manifold. To this end, we present a principled way of comparing shape trends in terms of a functional-based Riemannian metric. Remarkably, this metric allows efficient, yet simple computations by virtue of a variational time discretization requiring only the solution of regression problems. We validate our model on longitudinal data from the osteoarthritis initiative, including classification of disease progression.}, language = {en} } @inproceedings{MyersUtpalaTalbaretal.2022, author = {Myers, Adele and Utpala, Saiteja and Talbar, Shubham and Sanborn, Sophia and Shewmake, Christian and Donnat, Claire and Mathe, Johan and Lupo, Umberto and Sonthalia, Rishi and Cui, Xinyue and Szwagier, Tom and Pignet, Arthur and Bergsson, Andri and Hauberg, S{\o}ren and Nielsen, Dmitriy and Sommer, Stefan and Klindt, David and Hermansen, Erik and Vaupel, Melvin and Dunn, Benjamin and Xiong, Jeffrey and Aharony, Noga and Pe'er, Itsik and Ambellan, Felix and Hanik, Martin and Navayazdani, Esfandiar and Tycowicz, Christoph von and Miolane, Nina}, title = {ICLR 2022 Challenge for Computational Geomerty \& Topology: Design and Results}, volume = {196}, booktitle = {Proceedings of Topology, Algebra, and Geometry in Learning}, publisher = {PMLR}, arxiv = {http://arxiv.org/abs/2206.09048}, pages = {269 -- 276}, year = {2022}, language = {en} } @inproceedings{SchadevonTycowiczHanik2025, author = {Schade, Johannes and von Tycowicz, Christoph and Hanik, Martin}, title = {Bi-invariant Geodesic Regression with Data from the Osteoarthritis Initiative}, booktitle = {Information Processing in Medical Imaging}, publisher = {Springer}, address = {Lecture Notes in Computer Science}, arxiv = {http://arxiv.org/abs/2502.11826}, doi = {10.1007/978-3-031-96628-6_4}, pages = {49 -- 63}, year = {2025}, abstract = {Many phenomena are naturally characterized by measuring continuous transformations such as shape changes in medicine or articulated systems in robotics. Modeling the variability in such datasets requires performing statistics on Lie groups, that is, manifolds carrying an additional group structure. As the Lie group captures the symmetries in the data, it is essential from a theoretical and practical perspective to ask for statistical methods that respect these symmetries; this way they are insensitive to confounding effects, e.g., due to the choice of reference coordinate systems. In this work, we investigate geodesic regression---a generalization of linear regression originally derived for Riemannian manifolds. While Lie groups can be endowed with Riemannian metrics, these are generally incompatible with the group structure. We develop a non-metric estimator using an affine connection setting. It captures geodesic relationships respecting the symmetries given by left and right translations. For its computation, we propose an efficient fixed point algorithm requiring simple differential expressions that can be calculated through automatic differentiation. We perform experiments on a synthetic example and evaluate our method on an open-access, clinical dataset studying knee joint configurations under the progression of osteoarthritis.}, language = {en} }