@misc{HarmanSagnol, author = {Harman, Radoslav and Sagnol, Guillaume}, title = {Computing D-optimal experimental designs for estimating treatment contrasts under the presence of a nuisance time trend}, issn = {1438-0064}, doi = {10.1007/978-3-319-13881-7_10}, url = {http://nbn-resolving.de/urn:nbn:de:0297-zib-53640}, abstract = {We prove a mathematical programming characterisation of approximate partial D-optimality under general linear constraints. We use this characterisation with a branch-and-bound method to compute a list of all exact D-optimal designs for estimating a pair of treatment contrasts in the presence of a nuisance time trend up to the size of 24 consecutive trials.}, language = {en} }