@article{WitzigGleixner2020, author = {Witzig, Jakob and Gleixner, Ambros}, title = {Conflict-Driven Heuristics for Mixed Integer Programming}, volume = {33}, journal = {INFORMS Journal on Computing}, number = {2}, doi = {10.1287/ijoc.2020.0973}, pages = {706 -- 720}, year = {2020}, abstract = {Two essential ingredients of modern mixed-integer programming (MIP) solvers are diving heuristics that simulate a partial depth-first search in a branch-and-bound search tree and conflict analysis of infeasible subproblems to learn valid constraints. So far, these techniques have mostly been studied independently: primal heuristics under the aspect of finding high-quality feasible solutions early during the solving process and conflict analysis for fathoming nodes of the search tree and improving the dual bound. Here, we combine both concepts in two different ways. First, we develop a diving heuristic that targets the generation of valid conflict constraints from the Farkas dual. We show that in the primal this is equivalent to the optimistic strategy of diving towards the best bound with respect to the objective function. Secondly, we use information derived from conflict analysis to enhance the search of a diving heuristic akin to classical coefficient diving. The computational performance of both methods is evaluated using an implementation in the source-open MIP solver SCIP. Experiments are carried out on publicly available test sets including Miplib 2010 and Cor@l.}, language = {en} } @article{WitzigBerthold2021, author = {Witzig, Jakob and Berthold, Timo}, title = {Conflict Analysis for MINLP}, volume = {33}, journal = {INFORMS Journal on Computing}, number = {2}, doi = {10.1287/ijoc.2020.1050}, pages = {421 -- 435}, year = {2021}, abstract = {The generalization of MIP techniques to deal with nonlinear, potentially non-convex, constraints have been a fruitful direction of research for computational MINLP in the last decade. In this paper, we follow that path in order to extend another essential subroutine of modern MIP solvers towards the case of nonlinear optimization: the analysis of infeasible subproblems for learning additional valid constraints. To this end, we derive two different strategies, geared towards two different solution approaches. These are using local dual proofs of infeasibility for LP-based branch-and-bound and the creation of nonlinear dual proofs for NLP-based branch-and-bound, respectively. We discuss implementation details of both approaches and present an extensive computational study, showing that both techniques can significantly enhance performance when solving MINLPs to global optimality.}, language = {en} } @article{WitzigBeckenbachEifleretal.2018, author = {Witzig, Jakob and Beckenbach, Isabel and Eifler, Leon and Fackeldey, Konstantin and Gleixner, Ambros and Grever, Andreas and Weber, Marcus}, title = {Mixed-Integer Programming for Cycle Detection in Non-reversible Markov Processes}, volume = {16}, journal = {Multiscale Modeling and Simulation}, number = {1}, issn = {1438-0064}, doi = {10.1137/16M1091162}, pages = {248 -- 265}, year = {2018}, abstract = {In this paper, we present a new, optimization-based method to exhibit cyclic behavior in non-reversible stochastic processes. While our method is general, it is strongly motivated by discrete simulations of ordinary differential equations representing non-reversible biological processes, in particular molecular simulations. Here, the discrete time steps of the simulation are often very small compared to the time scale of interest, i.e., of the whole process. In this setting, the detection of a global cyclic behavior of the process becomes difficult because transitions between individual states may appear almost reversible on the small time scale of the simulation. We address this difficulty using a mixed-integer programming model that allows us to compute a cycle of clusters with maximum net flow, i.e., large forward and small backward probability. For a synthetic genetic regulatory network consisting of a ring-oscillator with three genes, we show that this approach can detect the most productive overall cycle, outperforming classical spectral analysis methods. Our method applies to general non-equilibrium steady state systems such as catalytic reactions, for which the objective value computes the effectiveness of the catalyst.}, language = {en} } @article{BestuzhevaBesanconChenetal.2023, author = {Bestuzheva, Ksenia and Besan{\c{c}}on, Mathieu and Chen, Wei-Kun and Chmiela, Antonia and Donkiewicz, Tim and Doornmalen, Jasper and Eifler, Leon and Gaul, Oliver and Gamrath, Gerald and Gleixner, Ambros and Gottwald, Leona and Graczyk, Christoph and Halbig, Katrin and Hoen, Alexander and Hojny, Christopher and Hulst, Rolf and Koch, Thorsten and L{\"u}bbecke, Marco and Maher, Stephen J. and Matter, Frederic and M{\"u}hmer, Erik and M{\"u}ller, Benjamin and Pfetsch, Marc and Rehfeldt, Daniel and Schlein, Steffan and Schl{\"o}sser, Franziska and Serrano, Felipe and Shinano, Yuji and Sofranac, Boro and Turner, Mark and Vigerske, Stefan and Wegscheider, Fabian and Wellner, Philipp and Weninger, Dieter and Witzig, Jakob}, title = {Enabling research through the SCIP optimization suite 8.0}, volume = {49}, journal = {ACM Transactions on Mathematical Software}, number = {2}, doi = {10.1145/3585516}, pages = {1 -- 21}, year = {2023}, abstract = {The SCIP Optimization Suite provides a collection of software packages for mathematical optimization centered around the constraint integer programming framework SCIP. The focus of this article is on the role of the SCIP Optimization Suite in supporting research. SCIP's main design principles are discussed, followed by a presentation of the latest performance improvements and developments in version 8.0, which serve both as examples of SCIP's application as a research tool and as a platform for further developments. Furthermore, this article gives an overview of interfaces to other programming and modeling languages, new features that expand the possibilities for user interaction with the framework, and the latest developments in several extensions built upon SCIP.}, language = {en} } @article{HalbigHoenGleixneretal.2025, author = {Halbig, Katrin and Hoen, Alexander and Gleixner, Ambros and Witzig, Jakob and Weninger, Dieter}, title = {A diving heuristic for mixed-integer problems with unbounded semi-continuous variables}, volume = {13}, journal = {EURO Journal on Computational Optimization}, doi = {10.1016/j.ejco.2025.100107}, year = {2025}, language = {en} }