@article{SchulzYamamotoKlosseketal.2019, author = {Schulz, Robert and Yamamoto, Kenji and Klossek, Andr{\´e} and Rancan, Fiorenza and Vogt, Annika and Sch{\"u}tte, Christof and R{\"u}hl, Eckart and Netz, Roland R.}, title = {Modeling of Drug Diffusion Based on Concentration Profiles in Healthy and Damaged Human Skin}, volume = {117}, journal = {Biophysical Journal}, number = {5}, doi = {10.1016/j.bpj.2019.07.027}, pages = {998 -- 1008}, year = {2019}, abstract = {Based on experimental drug concentration profiles in healthy as well as tape-stripped ex vivo human skin, we model the penetration of the antiinflammatory drug dexamethasone into the skin layers by the one-dimensional generalized diffusion equation. We estimate the position-dependent free-energy and diffusivity profiles by solving the conjugated minimization problem, in which the only inputs are concentration profiles of dexamethasone in skin at three consecutive penetration times. The resulting free-energy profiles for damaged and healthy skin show only minor differences. In contrast, the drug diffusivity in the first 10 μm of the upper skin layer of damaged skin is 200-fold increased compared to healthy skin, which reflects the corrupted barrier function of tape-stripped skin. For the case of healthy skin, we examine the robustness of our method by analyzing the behavior of the extracted skin parameters when the number of input and output parameters are reduced. We also discuss techniques for the regularization of our parameter extraction method.}, language = {en} } @article{LangenhanBorndoerferLoebeletal.2012, author = {Langenhan, Andreas and Bornd{\"o}rfer, Ralf and L{\"o}bel, Andreas and Schulz, Christof and Weider, Steffen}, title = {Duty Scheduling Templates}, journal = {Proceedings of Conference on Advanced Systems for Public Transport 2012 (CASPT12)}, editor = {Mu{\~n}oz, J. C. and Voß, S.}, year = {2012}, abstract = {We propose duty templates as a novel concept to produce similar duty schedules for similar days of operation in public transit. Duty templates can conveniently handle various types of similarity requirements, and they can be implemented with ease using standard algorithmic techniques. They have produced good results in practice.}, language = {en} } @article{GilgKlugMartienssenetal.2018, author = {Gilg, Brady and Klug, Torsten and Martienssen, Rosemarie and Paat, Joseph and Schlechte, Thomas and Schulz, Christof and Seymen, Senan and Tesch, Alexander}, title = {Conflict-free railway track assignment at depots}, journal = {Journal of Rail Transport Planning \& Management}, doi = {10.1016/j.jrtpm.2017.12.004}, year = {2018}, abstract = {Managing rolling stock with no passengers aboard is a critical component of railway operations. One aspect of managing rolling stock is to park the rolling stock on a given set of tracks at the end of a day or service. Depending on the parking assignment, shunting may be required in order for a parked train to depart or for an incoming train to park. Given a collection of tracks M and a collection of trains T with a fixed arrival-departure timetable, the train assignment problem (TAP) is to determine the maximum number of trains from T that can be parked on M according to the timetable and without the use of shunting. Hence, efficiently solving the TAP allows to quickly compute feasible parking schedules that do not require further shunting adjustments. In this paper, we show that the TAP is NP-hard and present two integer programming models for solving the TAP. We compare both models on a theoretical level. Moreover, to our knowledge, we consider the first approach that integrates track lengths along with the three most common types of parking tracks FIFO, LIFO and FREE tracks in a common model. Furthermore, to optimize against uncertainty in the arrival times of the trains we extend our models by stochastic and robust modeling techniques. We conclude by giving computational results for both models, observing that they perform well on real timetables.}, language = {en} } @article{BreugemSchlechteSchulzetal.2023, author = {Breugem, Thomas and Schlechte, Thomas and Schulz, Christof and Bornd{\"o}rfer, Ralf}, title = {A three-phase heuristic for the Fairness-Oriented Crew Rostering Problem}, volume = {154}, journal = {Computers \& Operations Research}, doi = {10.1016/j.cor.2023.106186}, pages = {106186}, year = {2023}, abstract = {The Fairness-Oriented Crew Rostering Problem (FCRP) considers the joint optimization of attractiveness and fairness in cyclic crew rostering. Like many problems in scheduling and logistics, the combinatorial complexity of cyclic rostering causes exact methods to fail for large-scale practical instances. In case of the FCRP, this is accentuated by the additionally imposed fairness requirements. Hence, heuristic methods are necessary. We present a three-phase heuristic for the FCRP combining column generation techniques with variable-depth neighborhood search. The heuristic exploits different mathematical formulations to find feasible solutions and to search for improvements. We apply our methodology to practical instances from Netherlands Railways (NS), the main passenger railway operator in the Netherlands Our results show the three-phase heuristic finds good solutions for most instances and outperforms a state-of-the-art commercial solver.}, language = {en} }