@article{AlchikhConradHoppeetal.2018, author = {Alchikh, Maren and Conrad, Tim and Hoppe, Christian and Ma, Xiaolin and Broberg, Eeva K. and Penttinen, P. and Reiche, J. and Biere, Barbara and Schweiger, Brunhilde and Rath, Barbara}, title = {Are we missing respiratory viral infections in infants and children? Comparison of a hospital-based quality management system with standard of care. Clinical Microbiology and Infection}, journal = {Clinical Microbiology and Infection}, number = {06/18}, doi = {10.1016/j.cmi.2018.05.023}, pages = {1 -- 1}, year = {2018}, language = {en} } @article{AlchikhConradMaetal.2019, author = {Alchikh, Maren and Conrad, Tim and Ma, Xiaolin and Broberg, Eeva K. and Penttinen, P. and Reiche, J. and Biere, Barbara and Schweiger, Brunhilde and Rath, Barbara and Hoppe, Christian}, title = {Are we missing respiratory viral infections in infants and children? Comparison of a hospital-based quality management system with standard of care}, volume = {25}, journal = {Clinical Microbiology and Infection}, number = {3}, issn = {1469-0691}, doi = {10.1016/j.cmi.2018.05.023}, pages = {380.e9 -- 380.e16}, year = {2019}, language = {en} } @article{ObermeierHeimBiereetal.2022, author = {Obermeier, Patrick E and Heim, Albert and Biere, Barbara and Hage, Elias and Alchikh, Maren and Conrad, Tim and Schweiger, Brunhilde and Rath, Barbara A}, title = {Linking digital surveillance and in-depth virology to study clinical patterns of viral respiratory infections in vulnerable patient populations}, volume = {25}, journal = {iScience}, number = {5}, publisher = {Cell Press}, doi = {10.1016/j.isci.2022.104276}, year = {2022}, abstract = {To improve the identification and management of viral respiratory infections, we established a clinical and virologic surveillance program for pediatric patients fulfilling pre-defined case criteria of influenza-like illness and viral respiratory infections. The program resulted in a cohort comprising 6,073 patients (56\% male, median age 1.6 years, range 0-18.8 years), where every patient was assessed with a validated disease severity score at the point-of-care using the ViVI ScoreApp. We used machine learning and agnostic feature selection to identify characteristic clinical patterns. We tested all patients for human adenoviruses, 571 (9\%) were positive. Adenovirus infections were particularly common and mild in children ≥1 month of age but rare and potentially severe in neonates: with lower airway involvement, disseminated disease, and a 50\% mortality rate (n = 2/4). In one fatal case, we discovered a novel virus …}, language = {en} } @article{ObermeierHeimBiereetal.2018, author = {Obermeier, Patrick and Heim, A. and Biere, Barbara and Hage, E. and Alchikh, Maren and Conrad, Tim and Schweiger, Brunhilde and Rath, Barbara}, title = {Clinical characteristics and disease severity associated with adenovirus infections in infants and children - discovery of a novel adenovirus, HAdV-D80}, journal = {Clinical Infectious Diseases}, year = {2018}, language = {en} }