@article{Lange, author = {Lange, Alexander}, title = {Reconstruction of disease transmission rates: applications to measles, dengue, and influenza}, series = {Journal of Theoretical Biology}, volume = {400}, journal = {Journal of Theoretical Biology}, doi = {10.1016/j.jtbi.2016.04.017}, pages = {138 -- 153}, language = {en} } @article{BauerGribovaLangeetal., author = {Bauer, Gernot and Gribova, Nadezhda and Lange, Alexander and Holm, Christian and Gross, Joachim}, title = {Three-body effects in triplets of capped gold nanocrystals}, series = {Molecular Physics}, volume = {115}, journal = {Molecular Physics}, doi = {10.1080/00268976.2016.1213909}, pages = {1031 -- 1040}, language = {en} } @inproceedings{LangePloentzkeSchaeferetal., author = {Lange, Alexander and Pl{\"o}ntzke, Julia and Sch{\"a}fer, Stefan and R{\"o}blitz, Susanna}, title = {Follicular maturation in cows: mathematical models and data}, series = {10. European Conference on Mathematical and Theoretical Biology}, booktitle = {10. European Conference on Mathematical and Theoretical Biology}, language = {en} } @inproceedings{Lange, author = {Lange, Alexander}, title = {A mathematical framework for predicting lifestyles of viral pathogens}, series = {Modelling Biological Evolution 2017: Developing Novel Approaches}, booktitle = {Modelling Biological Evolution 2017: Developing Novel Approaches}, language = {en} } @misc{LangeSchwiegerPloentzkeetal., author = {Lange, Alexander and Schwieger, Robert and Pl{\"o}ntzke, Julia and Sch{\"a}fer, Stefan and R{\"o}blitz, Susanna}, title = {Follicular competition: the selection of dominant follicles as a synergistic effect}, issn = {1438-0064}, doi = {https://doi.org/10.1007/s00285-018-1284-0}, url = {http://nbn-resolving.de/urn:nbn:de:0297-zib-63863}, abstract = {The estrous cycle of mono-ovulatory species such as cows or humans, is known to show two or more waves of follicular growth and decline between two successive ovulations. Within each wave, there is one dominant follicle escorted by subordinate follicles of varying number. Under the surge of the luteinizing hormone a growing dominant follicle ovulates. Rarely the number of ovulating follicles exceeds one. In the biological literature, the change of hormonal concentrations and individually varying numbers of follicular receptors are made responsible for the selection of exactly one dominant follicle, yet a clear cause has not been identified. In this paper, we suggest a synergistic explanation based on competition, formulated by a parsimoniously defined system of ordinary differential equations (ODEs) that quantifies the time evolution of multiple follicles and their competitive interaction during one wave. Not discriminating between follicles, growth and decline are given by fixed rates. Competition is introduced via a growth-suppressing term, equally supported by all follicles. We prove that the number of dominant follicles is determined exclusively by the ratio of follicular growth and competition. This number turns out to be independent of the number of subordinate follicles. The asymptotic behavior of the corresponding dynamical system is investigated rigorously, where we demonstrate that the omega-limit set only contains fixed points. When also including follicular decline, our ODEs perfectly resemble ultrasound data of bovine follicles. Implications for the involved but not explicitly modeled hormones are discussed.}, language = {en} } @article{OmariLangePloentzkeetal.2019, author = {Omari, Mohamed and Lange, Alexander and Pl{\"o}ntzke, Julia and R{\"o}blitz, Susanna}, title = {Model-based exploration of the impact of glucose metabolism on the estrous cycle dynamics in dairy cows}, series = {Biology Direct}, volume = {15}, journal = {Biology Direct}, doi = {10.1186/s13062-019-0256-7}, year = {2019}, language = {en} } @misc{OmariLangePloentzkeetal., author = {Omari, Mohamed and Lange, Alexander and Pl{\"o}ntzke, Julia and R{\"o}blitz, Susanna}, title = {A Mathematical Model for the Influence of Glucose-Insulin Dynamics on the Estrous Cycle in Dairy Cows}, issn = {1438-0064}, url = {http://nbn-resolving.de/urn:nbn:de:0297-zib-73475}, abstract = {Nutrition plays a crucial role in regulating reproductive hormones and follicular development in cattle. This is visible particularly during the time of negative energy balance at the onset of milk production after calving. Here, elongated periods of anovulation have been observed, resulting from alterations in luteiniz- ing hormone concentrations, likely caused by lower glucose and insulin concen- trations in the blood. The mechanisms that result in a reduced fertility are not completely understood, although a close relationship to the glucose-insulin metabolism is widely supported. Following this idea, a mathematical model of the hormonal network combining reproductive hormones and hormones that are coupled to the glucose compartments within the body of the cow was developed. The model is built on ordinary differential equations and relies on previously introduced models on the bovine estrous cycle and the glucose-insulin dynam- ics. Necessary modifications and coupling mechanisms are thoroughly discussed. Depending on the composition and the amount of food, in particular the glu- cose content in the dry matter, the model quantifies reproductive hormones and follicular development over time. Simulation results for different nutritional regimes in lactating and non-lactating dairy cows are examined and compared with experimental studies. Regarding its applicability, this work is an early attempt towards developing in silico feeding strategies and may eventually help refining and reducing animal experiments.}, language = {en} } @article{LangeSchwiegerPloentzkeetal., author = {Lange, Alexander and Schwieger, Robert and Pl{\"o}ntzke, Julia and Sch{\"a}fer, Stefan and R{\"o}blitz, Susanna}, title = {Follicular competition in cows: the selection of dominant follicles as a synergistic effect}, series = {Journal of Mathematical Biology}, journal = {Journal of Mathematical Biology}, doi = {https://doi.org/10.1007/s00285-018-1284-0}, abstract = {The reproductive cycle of mono-ovulatory species such as cows or humans is known to show two or more waves of follicular growth and decline between two successive ovulations. Within each wave, there is one dominant follicle escorted by subordinate follicles of varying number. Under the surge of the luteinizing hormone a growing dominant follicle ovulates. Rarely the number of ovulating follicles exceeds one. In the biological literature, the change of hormonal concentrations and individually varying numbers of follicular receptors are made responsible for the selection of exactly one dominant follicle, yet a clear cause has not been identified. In this paper, we suggest a synergistic explanation based on competition, formulated by a parsimoniously defined system of ordinary differential equations (ODEs) that quantifies the time evolution of multiple follicles and their competitive interaction during one wave. Not discriminating between follicles, growth and decline are given by fixed rates. Competition is introduced via a growth-suppressing term, equally supported by all follicles. We prove that the number of dominant follicles is determined exclusively by the ratio of follicular growth and competition. This number turns out to be independent of the number of subordinate follicles. The asymptotic behavior of the corresponding dynamical system is investigated rigorously, where we demonstrate that the ω-limit set only contains fixed points. When also including follicular decline, our ODEs perfectly resemble ultrasound data of bovine follicles. Implications for the involved but not explicitly modeled hormones are discussed.}, language = {en} }