@misc{SeebassSullivanWustetal., author = {Seebass, Martin and Sullivan, Dennis and Wust, Peter and Deuflhard, Peter and Felix, Roland}, title = {The Berlin Extension of the Stanford Hyperthermia Treatment.}, url = {http://nbn-resolving.de/urn:nbn:de:0297-zib-1304}, number = {SC-93-35}, abstract = {In the field of deep regional hyperthermia, one of the most widely used devices is the BSD--2000 Hyperthermia System which employs the Sigma 60 applicator. The Sigma 60 consists of four independent sources, giving it the potential to control the energy pattern within the patient. The independent amplitudes and phases, as well as frequency selection and applicator position, present a large number of parameters for the operator to determine. Computer simulation has long been recognized as an attractive approach to optimizing these parameters. A treatment planning program was used in clinical practice at Stanford University Medical Center for two years. It demonstrated the feasibility of computer simulation for deep regional hyperthermia in a clinical situation. However, several parts of this system were written in a language specific to one workstation, which severely restricted the wider distribution of the program to other users of the Sigma 60. A new treatment planning system for the BSD 2000 has been developed and put into clinical practice at the Rudolf Virchow Clinic of the Free University of Berlin. The new method, which we will refer to as the Berlin system, has a simpler model construction program and a considerably better graphics capability. However, the most important feature is that all programs are written in FORTRAN, C, or the X Window graphics system. Therefore, the entire treatment planning system is completely portable to other workstations.}, language = {en} } @inproceedings{NadobnyWustSeebassetal.1995, author = {Nadobny, Johanna and Wust, Peter and Seebass, Martin and Deuflhard, Peter and Felix, Roland}, title = {The Use of the Volume-Surface Integral Equation Method (VSIE) for Antenna Problems}, series = {Proc. COST 244 meeting on Reference Models for Bioelectromagnetic Test of Mobile Communication Systems, Roma, November 1994}, booktitle = {Proc. COST 244 meeting on Reference Models for Bioelectromagnetic Test of Mobile Communication Systems, Roma, November 1994}, editor = {Simunic, D.}, pages = {67 -- 74}, year = {1995}, language = {en} } @article{SeebassWustGellermannetal.1995, author = {Seebaß, Martin and Wust, Peter and Gellermann, Johanna and Stalling, Detlev and Nadobny, Jacek and Felix, Roland}, title = {Dreidimensionale Simulation der nicht-invasiven Radiowellen-Hyperthermie}, series = {Minimal Invasive Medizin}, volume = {6}, journal = {Minimal Invasive Medizin}, number = {1}, pages = {29 -- 35}, year = {1995}, language = {en} } @misc{BeckDeuflhardHegeetal., author = {Beck, Rudolf and Deuflhard, Peter and Hege, Hans-Christian and Seebass, Martin and Stalling, Detlev}, title = {Numerical Algorithms and Visualization in Medical Treament Planning}, url = {http://nbn-resolving.de/urn:nbn:de:0297-zib-2643}, number = {SC-96-54}, abstract = {After a short summary on therapy planning and the underlying technologies we discuss quantitative medicine by giving a short overview on medical image data, summarizing some applications of computer based treatment planning, and outlining requirements on medical planning systems. Then we continue with a description of our medical planning system {\sf HyperPlan}. It supports typical working steps in therapy planning, like data aquisition, segmentation, grid generation, numerical simulation and optimization, accompanying these with powerful visualization and interaction techniques.}, language = {en} } @inproceedings{BeckHegeSeebassetal.1996, author = {Beck, Rudolf and Hege, Hans-Christian and Seebass, Martin and Wust, Peter and Deuflhard, Peter and Felix, Roland}, title = {Adaptive finite element codes for numerical calculations in hyperthermia treatment planning}, series = {Proc. of the 7th Int. Congress on Hyperthermic Oncology, Rome, Italy, April 1996}, volume = {2}, booktitle = {Proc. of the 7th Int. Congress on Hyperthermic Oncology, Rome, Italy, April 1996}, editor = {Franconi, Cafiero}, pages = {515 -- 517}, year = {1996}, language = {en} } @article{NadobnyWustSeebassetal.1996, author = {Nadobny, Johanna and Wust, Peter and Seebass, Martin and Deuflhard, Peter and Felix, Roland}, title = {A Volume-Surface Integral Method for Solving Maxwell's Equations in Electrically Inhomogeneous Media Using Tetrahedral Grids}, series = {IEEE Transactions on Microwave Theory and Techniques}, volume = {44}, journal = {IEEE Transactions on Microwave Theory and Techniques}, number = {4}, pages = {543 -- 554}, year = {1996}, language = {en} } @inproceedings{NadobnyWustWlodarczyketal.1996, author = {Nadobny, Johanna and Wust, Peter and Wlodarczyk, Waldemar and Seebass, Martin and Deuflhard, Peter and Felix, Roland}, title = {Simulation Studies for Combination of Hyperthermia and Magnetic Resonance Systems}, series = {Proc. of the 7th Int. Congress on Hyperthermic Oncology, Rome, Italy, April 1996}, volume = {2}, booktitle = {Proc. of the 7th Int. Congress on Hyperthermic Oncology, Rome, Italy, April 1996}, editor = {Franconi, Cafiero}, pages = {549 -- 551}, year = {1996}, language = {en} } @incollection{BeckDeuflhardHegeetal.1996, author = {Beck, Rudolf and Deuflhard, Peter and Hege, Hans-Christian and Seebaß, Martin and Stalling, Detlev}, title = {Numerical Algorithms and Visualization in Medical Treatment Planning}, series = {Visualization and Mathematics 1997}, booktitle = {Visualization and Mathematics 1997}, editor = {Hege, Hans-Christian and Polthier, Konrad}, publisher = {Springer, Heidelberg}, pages = {303 -- 328}, year = {1996}, language = {en} } @inproceedings{BeckHegeSeebassetal.1996, author = {Beck, Rudolf and Hege, Hans-Christian and Seebaß, Martin and Wust, Peter and Deuflhard, Peter and Felix, Roland}, title = {Adaptive Finite Element Codes for Numerical Calculations in Hyperthermia Treatment Planning}, series = {Proceedings of the 17th Congress on Hyperthermic Oncology}, volume = {2}, booktitle = {Proceedings of the 17th Congress on Hyperthermic Oncology}, address = {Rome, Italy}, pages = {515 -- 517}, year = {1996}, language = {en} } @article{NadobnyWustSeebassetal.1996, author = {Nadobny, Jacek and Wust, Peter and Seebaß, Martin and Deuflhard, Peter and Felix, Roland}, title = {A Volume Surface Integral Equation Method for Solving Maxwell's Equations in Electrically Inhomogeneous Media Using Tetrahedral Grids}, series = {IEEE Transactions Microwave Theory Techn.}, volume = {44}, journal = {IEEE Transactions Microwave Theory Techn.}, number = {4}, doi = {10.1109/22.491022}, pages = {543 -- 554}, year = {1996}, language = {en} } @inproceedings{NadobnyWustWlodarczyketal.1996, author = {Nadobny, Jacek and Wust, Peter and Wlodarczyk, Waldemar and Seebaß, Martin and Deuflhard, Peter and M{\"o}nich, Gerhard and Felix, Roland}, title = {Simulation Studies for Combination of Hyperthermia and Magnetic Resonance Systems}, series = {Proceedings of the 17th Congress on Hyperthermic Oncology}, volume = {2}, booktitle = {Proceedings of the 17th Congress on Hyperthermic Oncology}, address = {Rome, Italy}, pages = {549 -- 551}, year = {1996}, language = {en} } @inproceedings{SeebassStallingNadobnyetal.1996, author = {Seebaß, Martin and Stalling, Detlev and Nadobny, Jacek and Wust, Peter and Felix, Roland and Deuflhard, Peter}, title = {Three-Dimensional Finite Elements Mesh Generation for Numerical Simulations of Hyperthermia Treatments}, series = {Proceedings of the 17th Congress on Hyperthermic Oncology}, volume = {2}, booktitle = {Proceedings of the 17th Congress on Hyperthermic Oncology}, address = {Rome, Italy}, pages = {547 -- 548}, year = {1996}, language = {en} } @inproceedings{StallingSeebassHegeetal.1996, author = {Stalling, Detlev and Seebaß, Martin and Hege, Hans-Christian and Wust, Peter and Deuflhard, Peter and Felix, Roland}, title = {HyperPlan - an Integrated System for Treatment Planning in Regional Hyperthermia}, series = {Proceedings of the 17th Congress on Hyperthermic Oncology}, volume = {2}, booktitle = {Proceedings of the 17th Congress on Hyperthermic Oncology}, address = {Rome, Italy}, pages = {552 -- 554}, year = {1996}, language = {en} } @article{WustSeebassNadobnyetal.1996, author = {Wust, Peter and Seebaß, Martin and Nadobny, Jacek and Deuflhard, Peter and M{\"o}nich, Gerhard and Felix, Roland}, title = {Simulation Studies Promote Technological Development of Radiofrequency Phased Array Hyperthermia}, series = {Int. Journal of Hyperthermia}, volume = {12}, journal = {Int. Journal of Hyperthermia}, pages = {477 -- 494}, year = {1996}, language = {en} } @article{WustSeebassNadobnyetal.1996, author = {Wust, Peter and Seebass, Martin and Nadobny, Johanna and Deuflhard, Peter and M{\"o}nich, Gerhard and Felix, Roland}, title = {Simulation studies promote technological development of radiofrequency phased array hyperthermia}, series = {Int J Hyperthermia}, volume = {12}, journal = {Int J Hyperthermia}, number = {4}, pages = {477 -- 494}, year = {1996}, language = {en} } @inproceedings{SeebassStallingNadobnyetal.1996, author = {Seebass, Martin and Stalling, Detlev and Nadobny, Johanna and Wust, Peter and Felix, Roland and Deuflhard, Peter}, title = {Three-Dimensional Finite Element Mesh Generation for Numerical Simulations of Hyperthermia Treatments}, series = {Proc. of the 7th Int. Congress on Hyperthermic Oncology, Rome, Italy, April 1996}, volume = {2}, booktitle = {Proc. of the 7th Int. Congress on Hyperthermic Oncology, Rome, Italy, April 1996}, editor = {Franconi, Cafiero}, pages = {547 -- 548}, year = {1996}, language = {en} } @inproceedings{StallingSeebassHegeetal.1996, author = {Stalling, Detlev and Seebass, Martin and Hege, Hans-Christian and Wust, Peter and Deuflhard, Peter and Felix, Roland}, title = {HyperPlan - an integrated system for treatment planning in regional hyperthermia}, series = {Proc. of the 7th Int. Congress on Hyperthermic Oncology, Rome, Italy, April 1996}, volume = {2}, booktitle = {Proc. of the 7th Int. Congress on Hyperthermic Oncology, Rome, Italy, April 1996}, editor = {Franconi, Cafiero}, pages = {552 -- 554}, year = {1996}, language = {en} } @misc{DeuflhardLouisSchlegeletal., author = {Deuflhard, Peter and Louis, Alfred and Schlegel, W. and Seebass, Martin}, title = {Workshop "Scientific Computing in der Medizin" SCMED '97}, url = {http://nbn-resolving.de/urn:nbn:de:0297-zib-5474}, number = {TR-97-05}, abstract = {Die Arbeitstagung \glqq Scientific Computing in der Medizin\grqq , kurz SCMED \grq 97, findet vom 22. - 23. September 1997 im neu errichteten Geb{\"a}ude des Konrad-Zuse-Zentrums auf dem Dahlemer naturwissenschaftlichen Campus der Freien Universt{\"a}t Berlin statt.}, language = {en} } @misc{ErdmannLangSeebass, author = {Erdmann, Bodo and Lang, Jens and Seebass, Martin}, title = {Adaptive Solutions of Nonlinear Parabolic Equations with Application to Hyperthermia Treatments}, url = {http://nbn-resolving.de/urn:nbn:de:0297-zib-3130}, number = {SC-97-44}, abstract = {We present a self-adaptive finite element method to solve nonlinear evolution problems in 3D. An implicit time integrator of Rosenbrock type is coupled with a multilevel approach in space. The proposed method is applied to hyperthermia treatments to demonstrate its potential for the solving of complicated problems.}, language = {en} } @misc{HegeSeebassStallingetal., author = {Hege, Hans-Christian and Seebass, Martin and Stalling, Detlev and Z{\"o}ckler, Malte}, title = {A Generalized Marching Cubes Algorithm Based on Non-Binary Classifications}, url = {http://nbn-resolving.de/urn:nbn:de:0297-zib-2741}, number = {SC-97-05}, abstract = {We present a new technique for generating surface meshes from a uniform set of discrete samples. Our method extends the well-known marching cubes algorithm used for computing polygonal isosurfaces. While in marching cubes each vertex of a cubic grid cell is binary classified as lying above or below an isosurface, in our approach an arbitrary number of vertex classes can be specified. Consequently the resulting surfaces consist of patches separating volumes of two different classes each. Similar to the marching cubes algorithm all grid cells are traversed and classified according to the number of different vertex classes involved and their arrangement. The solution for each configuration is computed based on a model that assigns probabilities to the vertices and interpolates them. We introduce an automatic method to find a triangulation which approximates the boundary surfaces - implicitly given by our model - in a topological correct way. Look-up tables guarantee a high performance of the algorithm. In medical applications our method can be used to extract surfaces from a 3D segmentation of tomographic images into multiple tissue types. The resulting surfaces are well suited for subsequent volumetric mesh generation, which is needed for simulation as well as visualization tasks. The proposed algorithm provides a robust and unique solution, avoiding ambiguities occuring in other methods. The method is of great significance in modeling and animation too, where it can be used for polygonalization of non-manifold implicit surfaces.}, language = {en} } @misc{DeuflhardSeebassStallingetal., author = {Deuflhard, Peter and Seebass, Martin and Stalling, Detlev and Beck, Rudolf and Hege, Hans-Christian}, title = {Hyperthermia Treatment Planning in Clinical Cancer Therapy: Modelling, Simulation and Visualization}, url = {http://nbn-resolving.de/urn:nbn:de:0297-zib-2958}, number = {SC-97-26}, abstract = {\noindent The speaker and his co-workers in Scientific Computing and Visualization have established a close cooperation with medical doctors at the Rudolf--Virchow--Klinikum of the Humboldt University in Berlin on the topic of regional hyperthermia. In order to permit a patient--specific treatment planning, a special software system ({\sf\small HyperPlan}) has been developed. \noindent A mathematical model of the clinical system ({\it radio frequency applicator with 8 antennas, water bolus, individual patient body}) involves Maxwell's equations in inhomogeneous media and a so--called bio--heat transfer PDE describing the temperature distribution in the human body. The electromagnetic field and the thermal phenomena need to be computed at a speed suitable for the clinical environment. An individual geometric patient model is generated as a quite complicated tetrahedral ``coarse'' grid (several thousands of nodes). Both Maxwell's equations and the bio--heat transfer equation are solved on that 3D--grid by means of {\em adaptive} multilevel finite element methods, which automatically refine the grid where necessary in view of the required accuracy. Finally optimal antenna parameters for the applicator are determined . \noindent All steps of the planning process are supported by powerful visualization methods. Medical images, contours, grids, simulated electromagnetic fields and temperature distributions can be displayed in combination. A number of new algorithms and techniques had to be developed and implemented. Special emphasis has been put on advanced 3D interaction methods and user interface issues.}, language = {en} } @misc{ErdmannLangSeebass, author = {Erdmann, Bodo and Lang, Jens and Seebass, Martin}, title = {Optimization of Temperature Distributions for Regional Hyperthermia Based on a Nonlinear Heat Transfer Model}, url = {http://nbn-resolving.de/urn:nbn:de:0297-zib-3283}, number = {SC-97-59}, abstract = {We describe an optimization process specially designed for regional hyperthermia of deap seated tumors in order to achieve desired steady--state temperature distributions. A nonlinear three--dimensional heat--transfer model based on temperature--dependent blood perfusion is applied to predict the temperature. Optimal heating is obtained by minimizing an integral object function which measures the distance between desired and model predicted temperatures. Sequential minima are calculated from successively improved constant--rate perfusion models employing a damped Newton method in an inner iteration. Numerical results for a Sigma 60 applicator are presented. This work has been supported by Deutsche Forschungsgemeinschaft (DFG) within the Sonderforschungsbereich 273 \glqq Hyperthermie: Methodik und Klinik \grqq .}, language = {en} } @inproceedings{BeckDeuflhardHegeetal.1997, author = {Beck, Rudolf and Deuflhard, Peter and Hege, Hans-Christian and Seebass, Martin and Stalling, Detlev}, title = {Numerical Algorithms and Visualization in Medical Treament Planning}, series = {Visualization and Mathematics}, booktitle = {Visualization and Mathematics}, editor = {Hege, Hans-Christian and Polthier, Konrad}, publisher = {Springer-Verlag}, pages = {303 -- 328}, year = {1997}, language = {en} } @inproceedings{NadobnyWustSeebassetal.1997, author = {Nadobny, Johanna and Wust, Peter and Seebass, Martin and Stalling, Detlev and Hege, Hans-Christian and Deuflhard, Peter and Felix, Roland}, title = {A Quantitative Comparison between the VSIE and the FDTD method using Electrically Equivalent Patient and Antenna Models}, series = {Proc. 16th Ann. Meeting Europ. Soc. Hyperthermic Oncology (ESHO-97), Berlin, Germany, April 1997}, booktitle = {Proc. 16th Ann. Meeting Europ. Soc. Hyperthermic Oncology (ESHO-97), Berlin, Germany, April 1997}, pages = {145}, year = {1997}, language = {en} } @inproceedings{DeuflhardSeebassStallingetal.1997, author = {Deuflhard, Peter and Seebass, Martin and Stalling, Detlev and Beck, Rudolf and Hege, Hans-Christian}, title = {Hyperthermia Treatment Planning in Clinical Cancer Therapy:Modelling, Simulation, and Visualization}, series = {Computational Physics, Chemistry and Biology}, volume = {3}, booktitle = {Computational Physics, Chemistry and Biology}, editor = {Sydow, Achim}, publisher = {Wissenschaft und Technik Verlag}, address = {Plenary keynote talk, 15th IMACS World Congress 1997 on Scientific Computation, Modelling and Applied Mathematics}, year = {1997}, language = {en} } @inproceedings{ErdmannLangSeebass1997, author = {Erdmann, Bodo and Lang, Jens and Seebass, Martin}, title = {Adaptive Solutions of Nonlinear Parabolic Equations with Application to Hyperthermia Treatments}, series = {CHT'97}, booktitle = {CHT'97}, editor = {de Vahl Davis, G. and Leonardi, E.}, address = {Cesme, Turkey}, pages = {103 -- 110}, year = {1997}, language = {en} } @inproceedings{GellermannWustStallingetal.1997, author = {Gellermann, Johanna and Wust, Peter and Stalling, Detlev and Tilly, Wolfgang and Nadobny, Johanna and Seebass, Martin and Deuflhard, Peter and Felix, Roland and Budach, Volker}, title = {First Clinical Experiences with the Hyperthermia Planning System HyperPlan}, series = {Proc. 16th Ann. Meeting Europ. Soc. Hyperthermic Oncology (ESHO-97), Berlin, Germany, April 1997}, booktitle = {Proc. 16th Ann. Meeting Europ. Soc. Hyperthermic Oncology (ESHO-97), Berlin, Germany, April 1997}, pages = {79}, year = {1997}, language = {en} } @inproceedings{SeebassStallingZoeckleretal.1997, author = {Seebaß, Martin and Stalling, Detlev and Z{\"o}ckler, Malte and Hege, Hans-Christian and Wust, Peter and Felix, Roland and Deuflhard, Peter}, title = {Surface Mesh Generation for Numerical Simulations of Hyperthermia Treatments}, series = {Proceedings of the 16th Annual Meeting of the European Society for Hyperthermic Oncology (ESHO-97)}, booktitle = {Proceedings of the 16th Annual Meeting of the European Society for Hyperthermic Oncology (ESHO-97)}, pages = {146}, year = {1997}, language = {en} } @inproceedings{DeuflhardSeebassStallingetal.1997, author = {Deuflhard, Peter and Seebaß, Martin and Stalling, Detlev and Beck, Rudolf and Hege, Hans-Christian}, title = {Hyperthermia Treatment Planning in Clinical Therapy}, series = {Computational Physics, Chemistry and Biology (Proceedings of the 15th IMACS World Congress 1997 on Scientific Computation 3, Modelling and Applied Mathematics)}, booktitle = {Computational Physics, Chemistry and Biology (Proceedings of the 15th IMACS World Congress 1997 on Scientific Computation 3, Modelling and Applied Mathematics)}, editor = {Sydow, Achim}, publisher = {Wissenschaft und Technik Verlag}, pages = {9 -- 17}, year = {1997}, language = {en} } @inproceedings{WustNadobnyGellermannetal.1997, author = {Wust, Peter and Nadobny, Jacek and Gellermann, Johanna and Seebaß, Martin and Stalling, Detlev and Hege, Hans-Christian and Deuflhard, Peter and Felix, Roland}, title = {Patient Models and Algorithms for Hyperthermia Planning}, series = {Proceedings of the 16th Annual Meeting of the European Society for Hyperthermic Oncology ESHO-97}, booktitle = {Proceedings of the 16th Annual Meeting of the European Society for Hyperthermic Oncology ESHO-97}, year = {1997}, language = {en} } @inproceedings{SeebassStallingZoeckleretal.1997, author = {Seebass, Martin and Stalling, Detlev and Z{\"o}ckler, M. and Hege, Hans-Christian and Wust, Peter and Felix, Roland and Deuflhard, Peter}, title = {Surface Mesh Generation for Numerical Simulations of Hyperthermia Treatments}, series = {Proc. 16th Ann. Meeting Europ. Soc. Hyperthermic Oncology (ESHO-97), Berlin, Germany, April 1997}, booktitle = {Proc. 16th Ann. Meeting Europ. Soc. Hyperthermic Oncology (ESHO-97), Berlin, Germany, April 1997}, pages = {146}, year = {1997}, language = {en} } @inproceedings{WustNadobnyGellermannetal.1997, author = {Wust, Peter and Nadobny, Johanna and Gellermann, Johanna and Seebass, Martin and Stalling, Detlev and Hege, Hans-Christian and Deuflhard, Peter and Budach, Volker and Felix, Roland}, title = {Patient Models and Algorithms for Hyperthermia Planning}, series = {Proc. 16th Ann. Meeting Europ. Soc. Hyperthermic Oncology (ESHO-97), Berlin, Germany, April 1997}, booktitle = {Proc. 16th Ann. Meeting Europ. Soc. Hyperthermic Oncology (ESHO-97), Berlin, Germany, April 1997}, pages = {75}, year = {1997}, language = {en} } @misc{DeuflhardSeebass, author = {Deuflhard, Peter and Seebass, Martin}, title = {Adaptive Multilevel FEM as Decisive Tools in the Clinical Cancer Therapy Hyperthermia}, url = {http://nbn-resolving.de/urn:nbn:de:0297-zib-3739}, number = {SC-98-30}, abstract = {The paper surveys recent progress in a joint mathematical-medical project on cancer therapy planning. Within so-called regional hyperthermia the computational task is to tune a set of coupled radiofrequency antennas such that a carefully measured tumor is locally heated, but any outside hot spots are avoided. A mathematical model of the whole clinical system -- air, applicator with antennas, water bolus, individual patient body -- involves Maxwell's equations in inhomogeneous media and a parabolic bioheat transfer equation, which represents a simplified model of heat transfer in the human body (ignoring strong blood vessel heat transport). Both PDEs need to be computed fast and to medical reliability (!) on a workstation within a clinical environment. This requirement triggered a series of new algorithmic developments to be reported here, among which is an adaptive multilevel FEM for Maxwell's equations, which dominates the numerical simulation time. In total, however, the main bulk of computation time (see Table 3 in Section 4 below) still goes into segmentation -- a necessary preprocessing step in the construction a 3D virtual patient from the input of a stack of 2D computed tomograms (left out here).}, language = {en} } @misc{DeuflhardWeiserSeebass, author = {Deuflhard, Peter and Weiser, Martin and Seebass, Martin}, title = {A New Nonlinear Elliptic Multilevel FEM Applied to Regional Hyperthermia}, url = {http://nbn-resolving.de/urn:nbn:de:0297-zib-3785}, number = {SC-98-35}, abstract = {In the clinical cancer therapy of regional hyperthermia nonlinear perfusion effects inside and outside the tumor seem to play a not negligible role. A stationary model of such effects leads to a nonlinear Helmholtz term within an elliptic boundary value problem. The present paper reports about the application of a recently designed adaptive multilevel FEM to this problem. For several 3D virtual patients, nonlinear versus linear model is studied. Moreover, the numerical efficiency of the new algorithm is compared with a former application of an adaptive FEM to the corresponding instationary model PDE.}, language = {en} } @misc{LangErdmannSeebass, author = {Lang, Jens and Erdmann, Bodo and Seebass, Martin}, title = {Impact of Nonlinear Heat Transfer on Temperature Control in Regional Hyperthermia}, url = {http://nbn-resolving.de/urn:nbn:de:0297-zib-3426}, number = {SC-97-73}, abstract = {We describe an optimization process specially designed for regional hyperthermia of deep seated tumors in order to achieve desired steady--state temperature distributions. A nonlinear three--dimensional heat transfer model based on temperature--dependent blood perfusion is applied to predict the temperature. Using linearly implicit methods in time and adaptive multilevel finite elements in space, we are able to integrate efficiently the instationary nonlinear heat equation with high accuracy. Optimal heating is obtained by minimizing an integral object function which measures the distance between desired and model predicted temperatures. A sequence of minima is calculated from successively improved constant--rate perfusion models employing a damped Newton method in an inner iteration. We compare temperature distributions for two individual patients calculated on coarse and fine spatial grids and present numerical results of optimizations for a Sigma 60 Applicator of the BSD 2000 Hyperthermia System.}, language = {en} } @inproceedings{NadobnySullivanWustetal.1998, author = {Nadobny, Johanna and Sullivan, Dennis and Wust, Peter and Seebass, Martin and Deuflhard, Peter and Felix, Roland}, title = {A High Resolution Interpretation at Arbitrary Interfaces for the FDTD Method}, series = {IEEE Transactions on Microwave Theory and Techniques}, volume = {46}, booktitle = {IEEE Transactions on Microwave Theory and Techniques}, number = {11}, pages = {1759 -- 1766}, year = {1998}, language = {en} } @inproceedings{ErdmannLangSeebass1998, author = {Erdmann, Bodo and Lang, Jens and Seebass, Martin}, title = {Optimization of Temperature Distributions for Regional Hyperthermia based on a Nonlinear Heat Transfer Model}, series = {Biotransport}, volume = {858}, booktitle = {Biotransport}, editor = {Diller, K.}, pages = {36 -- 46}, year = {1998}, language = {en} } @inproceedings{SeebassStallingHegeetal.1998, author = {Seebaß, Martin and Stalling, Detlev and Hege, Hans-Christian and Wust, Peter and Felix, Roland and Deuflhard, Peter}, title = {New Features of HyperPlan, a Hyperthermia Planning System}, series = {Proc. Hyperthermia in Clincal Oncology}, booktitle = {Proc. Hyperthermia in Clincal Oncology}, address = {Venice}, pages = {16}, year = {1998}, language = {en} } @article{NadobnySullivanWustetal.1998, author = {Nadobny, Jacek and Sullivan, Dennis and Wust, Peter and Seebaß, Martin and Deuflhard, Peter and Felix, Roland}, title = {A High-Resolution Interpolation at Arbitary Interfaces for the FDTD Method}, series = {IEEE Trans. Microwave Theory Tech.}, volume = {46}, journal = {IEEE Trans. Microwave Theory Tech.}, number = {11}, doi = {10.1109/22.734576}, pages = {1759 -- 1766}, year = {1998}, language = {en} } @inproceedings{NadobnyWustFaehlingetal.1998, author = {Nadobny, Jacek and Wust, Peter and F{\"a}hling, Horst and Stalling, Detlev and Seebaß, Martin and Deuflhard, Peter and Felix, Roland}, title = {Numerical and Experimental Evaluation of E-Field and Absorbed Power in the Pelvic Region Using a Bone-Equivalent Phantom}, series = {Proc. PIERS Progress in Electromagnetic Research Symposium}, booktitle = {Proc. PIERS Progress in Electromagnetic Research Symposium}, address = {Nantes}, pages = {264}, year = {1998}, language = {en} } @misc{StallingSeebassZachow, author = {Stalling, Detlev and Seebass, Martin and Zachow, Stefan}, title = {Mehrschichtige Oberfl{\"a}chenmodelle zur computergest{\"u}tzten Planung in der Chirurgie}, url = {http://nbn-resolving.de/urn:nbn:de:0297-zib-5661}, number = {TR-98-05}, abstract = {Polygonale Sch{\"a}delmodelle bilden ein wichtiges Hilfsmittel f{\"u}r computergest{\"u}tzte Planungen im Bereich der plastischen Chirurgie. Wir beschreiben, wie derartige Modelle automatisch aus hochaufgel{\"o}sten CT-Datens{\"a}tzen erzeugt werden k{\"o}nnen. Durch einen lokal steuerbaren Simplifizierungsalgorithmus werden die Modelle so weit vereinfacht, daß auch auf kleineren Graphikcomputern interaktives Arbeiten m{\"o}glich wird. Die Verwendung eines speziellen Transparenzmodells erm{\"o}glicht den ungehinderten Blick auf die bei der Planung relevanten Knochenstrukturen und l{\"a}ßt den Benutzer zugleich die Kopfumrisse des Patienten erkennen.}, language = {de} } @inproceedings{DeuflhardSeebass1998, author = {Deuflhard, Peter and Seebaß, Martin}, title = {Adaptive Multilevel FEM as Decisive Tools in the Clinical Cancer Therapy Hyerthermia}, series = {Proc. Eleventh International Conference on Domain Decomposition Methods in Sciences and Engineering}, booktitle = {Proc. Eleventh International Conference on Domain Decomposition Methods in Sciences and Engineering}, editor = {Lai, Choi-Hong and Bjorstad, Petter and Cross, Mark and Widlund, Olof}, address = {Greenwich, UK}, pages = {410 -- 421}, year = {1998}, language = {en} } @inproceedings{DeuflhardSeebass1999, author = {Deuflhard, Peter and Seebass, Martin}, title = {Adaptive Multilevel FEM as Decisive Tools in the Clinical Cancer Therapy Hyperthermia}, series = {Procs. Eleventh International Conference on Domain Decomposition Methods}, booktitle = {Procs. Eleventh International Conference on Domain Decomposition Methods}, editor = {Lai, Choi-Hong and Bj{\o}rstad, Petter E. and Cross, Mark and Widlund, Olof}, publisher = {DDM-org Press,Bergen}, pages = {403 -- 414}, year = {1999}, language = {en} } @article{ErdmannLangSeebass1999, author = {Erdmann, Bodo and Lang, Jens and Seebass, Martin}, title = {The Impact of a Nonlinear Heat Transfer Model for Temperature Control in Regional Hyperthermia}, series = {IEEE Transactions on Biomedical Engineering}, volume = {49}, journal = {IEEE Transactions on Biomedical Engineering}, number = {9}, pages = {1129 -- 1138}, year = {1999}, language = {en} } @article{WustNadobnySeebassetal.1999, author = {Wust, Peter and Nadobny, Jacek and Seebaß, Martin and Stalling, Detlev and Gellermann, Johanna and Hege, Hans-Christian and Deuflhard, Peter}, title = {Influence of Patient Models and Numerical Methods on Predicted Power Deposition Patterns}, series = {Int. Journal Hyperthermia}, volume = {15}, journal = {Int. Journal Hyperthermia}, number = {6}, pages = {519 -- 540}, year = {1999}, language = {en} } @inproceedings{StallingSeebassZachow1999, author = {Stalling, Detlev and Seebaß, Martin and Zachow, Stefan}, title = {Mehrschichtige Oberfl{\"a}chenmodelle zur computergest{\"u}tzten Planung in der Chirurgie}, series = {Bildverarbeitung f{\"u}r die Medizin 1999 - Algorithmen, Anwendungen}, booktitle = {Bildverarbeitung f{\"u}r die Medizin 1999 - Algorithmen, Anwendungen}, publisher = {Springer-Verlag, Berlin}, pages = {203 -- 207}, year = {1999}, language = {en} } @article{LangErdmannSeebass1999, author = {Lang, Jens and Erdmann, Bodo and Seebaß, Martin}, title = {Impact of Nonlinear Heat Tansfer on Temperature Control in Regional Hypertermia}, series = {IEEE Trans. Biomed. Engrg.}, volume = {46}, journal = {IEEE Trans. Biomed. Engrg.}, doi = {10.1109/10.784145}, pages = {1129 -- 1138}, year = {1999}, language = {en} } @article{WustNadobnySeebassetal.1999, author = {Wust, Peter and Nadobny, Johanna and Seebass, Martin and Stalling, Detlev and Gellermann, Johanna and Hege, Hans-Christian and Deuflhard, Peter and Felix, Roland}, title = {Influence of patient models and numerical methods on predicted power deposition patterns}, series = {Int. J. Hyperthermia}, volume = {15}, journal = {Int. J. Hyperthermia}, number = {6}, pages = {519 -- 540}, year = {1999}, language = {en} } @misc{DeuflhardHegeSeebass, author = {Deuflhard, Peter and Hege, Hans-Christian and Seebass, Martin}, title = {Progress Towards a Combined MRI/Hyperthermia System}, url = {http://nbn-resolving.de/urn:nbn:de:0297-zib-5755}, number = {00-07}, abstract = {Regional hyperthermia, a clinical cancer therapy, is the main topic of the Sonderforschungsbereich Hyperthermia: Scientific Methods and Clinical Applications'' at Berlin. In recent years, technological improvements towards a better concentration of heat to the desired target region have been achieved. These include a rather sophisticated integrated software environment for therapy planning and a new hyperthermia applicator. In a next step, a detailed closed loop monitoring of the actual treatment is to be developed. For this purpose the hyperthermia applicator is combined with an MRI system, which will allow to check the positioning of the patients and to measure individual blood perfusion as well as the 3D temperature distribution. The measurements will then be employed for an on-line control of the whole treatment. In this intended setting, new fast feedback control algorithms will come into play.}, language = {en} } @misc{SeebassBeckGellermannetal., author = {Seebass, Martin and Beck, Rudolf and Gellermann, Johanna and Nadobny, Jacek and Wust, Peter}, title = {Electromagnetic phased arrays for regional hyperthermia -- optimal frequency and antenna arrangement}, url = {http://nbn-resolving.de/urn:nbn:de:0297-zib-5961}, number = {00-28}, abstract = {In this paper we investigate the effects of the three-dimensional arrangement of antennas and frequency on temperature distributions that can be achieved in regional hyperthermia using an electromagnetic phased array. We compare the results of power-based and temperature-based optimization. Thus we are able to explain the discrepancies between previous studies favouring more antenna rings on the one hand and more antennas per ring on the other hand. We analyze the sensitivity of the results with respect to changes in amplitudes and phases as well as patient position. This analysis can be used for different purposes. First, it provides additional criteria for selecting the optimal frequency. Second, it can be used for specifying the required phase and amplitude accuracy for a real phased array system. Furthermore, it may serve as a basis for technological developments in order to reduce both types of sensitivities described above.}, language = {en} }