@article{EggerDercksenUdvaryetal., author = {Egger, Robert and Dercksen, Vincent J. and Udvary, Daniel and Hege, Hans-Christian and Oberlaender, Marcel}, title = {Generation of dense statistical connectomes from sparse morphological data}, series = {Frontiers in Neuroanatomy}, volume = {8}, journal = {Frontiers in Neuroanatomy}, number = {129}, doi = {10.3389/fnana.2014.00129}, language = {en} } @article{LangDercksenSakmannetal.2011, author = {Lang, Stefan and Dercksen, Vincent J. and Sakmann, Bert and Oberlaender, Marcel}, title = {Simulation of signal flow in 3D reconstructions of an anatomically realistic neural network in rat vibrissal cortex}, series = {Neural Networks}, volume = {24}, journal = {Neural Networks}, number = {9}, doi = {doi:10.1016/j.neunet.2011.06.013}, pages = {998 -- 1011}, year = {2011}, language = {en} } @misc{DercksenOberlaenderSakmannetal.2011, author = {Dercksen, Vincent J. and Oberlaender, Marcel and Sakmann, Bert and Hege, Hans-Christian}, title = {Light Microscopy-Based Reconstruction and Interactive Structural Analysis of Cortical Neural Networks}, series = {BioVis 2011 Abstracts, 1st IEEE Symposium on Biological Data Visualization}, journal = {BioVis 2011 Abstracts, 1st IEEE Symposium on Biological Data Visualization}, year = {2011}, language = {en} } @inproceedings{DercksenEggerHegeetal.2012, author = {Dercksen, Vincent J. and Egger, Robert and Hege, Hans-Christian and Oberlaender, Marcel}, title = {Synaptic Connectivity in Anatomically Realistic Neural Networks: Modeling and Visual Analysis}, series = {Eurographics Workshop on Visual Computing for Biology and Medicine (VCBM)}, booktitle = {Eurographics Workshop on Visual Computing for Biology and Medicine (VCBM)}, address = {Norrk{\"o}ping, Sweden}, doi = {10.2312/VCBM/VCBM12/017-024}, pages = {17 -- 24}, year = {2012}, language = {en} } @article{OberlaenderdeKockBrunoetal.2012, author = {Oberlaender, Marcel and de Kock, Christiaan P. J. and Bruno, Randy M. and Ramirez, Alejandro and Meyer, Hanno and Dercksen, Vincent J. and Helmstaedter, Moritz and Sakmann, Bert}, title = {Cell Type-Specific Three-Dimensional Structure of Thalamocortical Circuits in a Column of Rat Vibrissal Cortex}, series = {Cerebral Cortex}, volume = {22}, journal = {Cerebral Cortex}, number = {10}, doi = {doi:10.1093/cercor/bhr317}, pages = {2375 -- 2391}, year = {2012}, language = {en} } @article{OberlaenderDercksenEggeretal.2009, author = {Oberlaender, Marcel and Dercksen, Vincent J. and Egger, Robert and Gensel, Maria and Sakmann, Bert and Hege, Hans-Christian}, title = {Automated three-dimensional detection and counting of neuron somata}, series = {Journal of Neuroscience Methods}, volume = {180}, journal = {Journal of Neuroscience Methods}, number = {1}, doi = {10.1016/j.jneumeth.2009.03.008}, pages = {147 -- 160}, year = {2009}, language = {en} } @misc{OberlaenderDercksenLangetal.2009, author = {Oberlaender, Marcel and Dercksen, Vincent J. and Lang, Stefan and Sakmann, Bert}, title = {3D mapping of synaptic connections within "in silico" microcircuits of full compartmental neurons in extended networks on the example of VPM axons projecting into S1 of rats.}, series = {Conference Abstract, Neuroinformatics}, journal = {Conference Abstract, Neuroinformatics}, doi = {10.3389/conf.neuro.11.2009.08.092}, year = {2009}, language = {en} } @misc{OberlaenderBrunodeKocketal.2009, author = {Oberlaender, Marcel and Bruno, Randy M. and de Kock, Christiaan P. J. and Meyer, Hanno and Dercksen, Vincent J. and Sakmann, Bert}, title = {3D distribution and sub-cellular organization of thalamocortical VPM synapses for individual excitatory neuronal cell types in rat barrel cortex}, series = {Conference Abstract No. 173.19/Y35, 39th Annual Meeting of the Society for Neuroscience (SfN)}, journal = {Conference Abstract No. 173.19/Y35, 39th Annual Meeting of the Society for Neuroscience (SfN)}, year = {2009}, language = {en} } @article{LandauEggerDercksenetal., author = {Landau, Itamar D. and Egger, Robert and Dercksen, Vincent J. and Oberlaender, Marcel and Sompolinsky, Haim}, title = {The Impact of Structural Heterogeneity on Excitation-Inhibition Balance in Cortical Networks}, series = {Neuron}, volume = {92}, journal = {Neuron}, number = {5}, doi = {10.1016/j.neuron.2016.10.027}, pages = {1106 -- 1121}, abstract = {Models of cortical dynamics often assume a homogeneous connectivity structure. However, we show that heterogeneous input connectivity can prevent the dynamic balance between excitation and inhibition, a hallmark of cortical dynamics, and yield unrealistically sparse and temporally regular firing. Anatomically based estimates of the connectivity of layer 4 (L4) rat barrel cortex and numerical simulations of this circuit indicate that the local network possesses substantial heterogeneity in input connectivity, sufficient to disrupt excitation-inhibition balance. We show that homeostatic plasticity in inhibitory synapses can align the functional connectivity to compensate for structural heterogeneity. Alternatively, spike-frequency adaptation can give rise to a novel state in which local firing rates adjust dynamically so that adaptation currents and synaptic inputs are balanced. This theory is supported by simulations of L4 barrel cortex during spontaneous and stimulus-evoked conditions. Our study shows how synaptic and cellular mechanisms yield fluctuation-driven dynamics despite structural heterogeneity in cortical circuits.}, language = {en} } @article{DercksenHegeOberlaender2014, author = {Dercksen, Vincent J. and Hege, Hans-Christian and Oberlaender, Marcel}, title = {The Filament Editor: An Interactive Software Environment for Visualization, Proof-Editing and Analysis of 3D Neuron Morphology}, series = {NeuroInformatics}, volume = {12}, journal = {NeuroInformatics}, number = {2}, publisher = {Springer US}, doi = {10.1007/s12021-013-9213-2}, pages = {325 -- 339}, year = {2014}, language = {en} }