@article{HildebrandtBrueningSchmidtetal.2019, author = {Hildebrandt, Thomas and Bruening, Jan Joris and Schmidt, Nora Laura and Lamecker, Hans and Heppt, Werner and Zachow, Stefan and Goubergrits, Leonid}, title = {The Healthy Nasal Cavity - Characteristics of Morphology and Related Airflow Based on a Statistical Shape Model Viewed from a Surgeon's Perspective}, volume = {35}, journal = {Facial Plastic Surgery}, number = {1}, doi = {10.1055/s-0039-1677721}, pages = {9 -- 13}, year = {2019}, abstract = {Functional surgery on the nasal framework requires referential criteria to objectively assess nasal breathing for indication and follow-up. Thismotivated us to generate amean geometry of the nasal cavity based on a statistical shape model. In this study, the authors could demonstrate that the introduced nasal cavity's mean geometry features characteristics of the inner shape and airflow, which are commonly observed in symptom-free subjects. Therefore, the mean geometry might serve as a reference-like model when one considers qualitative aspects. However, to facilitate quantitative considerations and statistical inference, further research is necessary. Additionally, the authorswere able to obtain details about the importance of the isthmus nasi and the inferior turbinate for the intranasal airstream.}, language = {en} } @article{HildebrandtBrueningLameckeretal.2019, author = {Hildebrandt, Thomas and Bruening, Jan Joris and Lamecker, Hans and Zachow, Stefan and Heppt, Werner and Schmidt, Nora and Goubergrits, Leonid}, title = {Digital Analysis of Nasal Airflow Facilitating Decision Support in Rhinosurgery}, volume = {35}, journal = {Facial Plastic Surgery}, number = {1}, doi = {10.1055/s-0039-1677720}, pages = {1 -- 8}, year = {2019}, abstract = {Successful functional surgery on the nasal framework requires reliable and comprehensive diagnosis. In this regard, the authors introduce a new methodology: Digital Analysis of Nasal Airflow (diANA). It is based on computational fluid dynamics, a statistical shape model of the healthy nasal cavity and rhinologic expertise. diANA necessitates an anonymized tomographic dataset of the paranasal sinuses including the complete nasal cavity and, when available, clinical information. The principle of diANA is to compare the morphology and the respective airflow of an individual nose with those of a reference. This enablesmorphometric aberrations and consecutive flow field anomalies to localize and quantify within a patient's nasal cavity. Finally, an elaborated expert opinion with instructive visualizations is provided. Using diANA might support surgeons in decision-making, avoiding unnecessary surgery, gaining more precision, and target-orientation for indicated operations.}, language = {en} } @article{BrueningHildebrandtHepptetal.2020, author = {Br{\"u}ning, Jan and Hildebrandt, Thomas and Heppt, Werner and Schmidt, Nora and Lamecker, Hans and Szengel, Angelika and Amiridze, Natalja and Ramm, Heiko and Bindernagel, Matthias and Zachow, Stefan and Goubergrits, Leonid}, title = {Characterization of the Airflow within an Average Geometry of the Healthy Human Nasal Cavity}, volume = {3755}, journal = {Scientific Reports}, number = {10}, doi = {10.1038/s41598-020-60755-3}, year = {2020}, abstract = {This study's objective was the generation of a standardized geometry of the healthy nasal cavity. An average geometry of the healthy nasal cavity was generated using a statistical shape model based on 25 symptom-free subjects. Airflow within the average geometry and these geometries was calculated using fluid simulations. Integral measures of the nasal resistance, wall shear stresses (WSS) and velocities were calculated as well as cross-sectional areas (CSA). Furthermore, individual WSS and static pressure distributions were mapped onto the average geometry. The average geometry featured an overall more regular shape that resulted in less resistance, reduced wall shear stresses and velocities compared to the median of the 25 geometries. Spatial distributions of WSS and pressure of average geometry agreed well compared to the average distributions of all individual geometries. The minimal CSA of the average geometry was larger than the median of all individual geometries (83.4 vs. 74.7 mm²). The airflow observed within the average geometry of the healthy nasal cavity did not equal the average airflow of the individual geometries. While differences observed for integral measures were notable, the calculated values for the average geometry lay within the distributions of the individual parameters. Spatially resolved parameters differed less prominently.}, language = {en} } @article{GoubergritsHellmeierBrueningetal.2019, author = {Goubergrits, Leonid and Hellmeier, Florian and Bruening, Jan Joris and Spuler, Andreas and Hege, Hans-Christian and Voss, Samuel and Janiga, G{\´a}bor and Saalfeld, Sylvia and Beuing, Oliver and Berg, Philipp}, title = {Multiple Aneurysms AnaTomy CHallenge 2018 (MATCH): Uncertainty Quantification of Geometric Rupture Risk Parameters}, volume = {18}, journal = {BioMedical Engineering OnLine}, number = {35}, doi = {10.1186/s12938-019-0657-y}, year = {2019}, abstract = {Background Geometric parameters have been proposed for prediction of cerebral aneurysm rupture risk. Predicting the rupture risk for incidentally detected unruptured aneurysms could help clinicians in their treatment decision. However, assessment of geometric parameters depends on several factors, including the spatial resolution of the imaging modality used and the chosen reconstruction procedure. The aim of this study was to investigate the uncertainty of a variety of previously proposed geometric parameters for rupture risk assessment, caused by variability of reconstruction procedures. Materials 26 research groups provided segmentations and surface reconstructions of five cerebral aneurysms as part of the Multiple Aneurysms AnaTomy CHallenge (MATCH) 2018. 40 dimensional and non-dimensional geometric parameters, describing aneurysm size, neck size, and irregularity of aneurysm shape, were computed. The medians as well as the absolute and relative uncertainties of the parameters were calculated. Additionally, linear regression analysis was performed on the absolute uncertainties and the median parameter values. Results A large variability of relative uncertainties in the range between 3.9 and 179.8\% was found. Linear regression analysis indicates that some parameters capture similar geometric aspects. The lowest uncertainties < 6\% were found for the non-dimensional parameters isoperimetric ratio, convexity ratio, and ellipticity index. Uncertainty of 2D and 3D size parameters was significantly higher than uncertainty of 1D parameters. The most extreme uncertainties > 80\% were found for some curvature parameters. Conclusions Uncertainty analysis is essential on the road to clinical translation and use of rupture risk prediction models. Uncertainty quantification of geometric rupture risk parameters provided by this study may help support development of future rupture risk prediction models.}, language = {en} } @article{HildebrandtGoubergritsHepptetal.2013, author = {Hildebrandt, Thomas and Goubergrits, Leonid and Heppt, Werner and Bessler, Stefan and Zachow, Stefan}, title = {Evaluation of the Intranasal Flow Field through Computational Fluid Dynamics (CFD)}, volume = {29}, journal = {Journal of Facial and Plastic Surgery}, number = {2}, publisher = {Thieme}, doi = {10.1055/s-0033-1341591}, pages = {93 -- 98}, year = {2013}, language = {en} } @article{GoubergritsSchallerKertzscheretal.2012, author = {Goubergrits, Leonid and Schaller, Jens and Kertzscher, Ulrich and van den Bruck, Nils and P{\"o}thkow, Kai and Petz, Christoph and Hege, Hans-Christian and Spuler, Andreas}, title = {Statistical wall shear stress maps of ruptured and unruptured middle cerebral artery aneurysms}, volume = {9}, journal = {J. R. Soc. Interface}, number = {69}, doi = {10.1098/rsif.2011.0490}, pages = {677 -- 688}, year = {2012}, language = {en} } @article{GoubergritsKertzscherAffeldetal.2008, author = {Goubergrits, Leonid and Kertzscher, Ulrich and Affeld, Klaus and Petz, Christoph and Stalling, Detlev}, title = {Numerical Dye Washout Method as a Tool for Characterizing the Heart Valve Flow}, volume = {54(1)}, journal = {ASAIO Journal}, doi = {10.1097/MAT.0b013e31815c5e38}, pages = {50 -- 57}, year = {2008}, language = {en} } @inproceedings{PoethkeGoubergritsKertzscheretal.2008, author = {Poethke, Jens and Goubergrits, Leonid and Kertzscher, Ulrich and Spuler, Andreas and Petz, Christoph and Hege, Hans-Christian}, title = {Impact of imaging modality for analysis of a cerebral aneurysm: Comparison between CT, MRI and 3DRA}, booktitle = {Proceedings of the 4th European Conference of the International Federation for Medical and Biological Engineering}, editor = {Jos Vander Sloten, Pascal and Haueisen, Jens}, publisher = {Springer-Verlag}, address = {Antwerp, Belgium}, doi = {10.1007/978-3-540-89208-3}, pages = {1889 -- 1893}, year = {2008}, language = {en} } @article{GoubergritsWeberPetzetal.2009, author = {Goubergrits, Leonid and Weber, Sarah and Petz, Christoph and Spuler, Andreas and P{\"o}thke, Jens and Berthe, Andr{\´e} and Hege, Hans-Christian}, title = {Wall-PIV as a Near Wall Flow Validation Tool for CFD}, volume = {12}, journal = {Journal of Visualization}, number = {3}, pages = {241 -- 250}, year = {2009}, language = {en} } @article{GoubergritsWellnhoferKertzscheretal.2009, author = {Goubergrits, Leonid and Wellnhofer, Ernst and Kertzscher, Ulrich and Affeld, Klaus and Petz, Christoph and Hege, Hans-Christian}, title = {Coronary Artery WSS Profiling Using a Geometry Reconstruction Based on Biplane Angiography}, volume = {37}, journal = {Annals of Biomedical Engineering}, number = {4}, publisher = {Springer}, doi = {s10439-009-9656-7}, pages = {682 -- 691}, year = {2009}, language = {en} }