TY - GEN A1 - Meyer, Michael A1 - Schnurre, RĂ¼diger A1 - Reissbrodt, Rolf A1 - Trowitzsch-Kienast, Wolfram T1 - Computer-aided design of novel siderophores: Pyridinochelin N2 - Pyridinochelin, a novel catecholate type siderophore, has been designed on the basis of the active analog enterobactin. Growth promotion tests indicate that this synthetic siderophore feeds various pathogenic bacteria effectively with iron even though it lacks one catecholate group compared to enterobactin. The superposition of the siderophore structures suggests that the structure of the skeleton connecting the catecholate groups might be an important factor for the iron transport. T3 - ZIB-Report - 00-20 KW - bioorganic chemistry KW - drug design KW - molecular modeling KW - iron transport KW - siderophore Y1 - 2000 UR - https://opus4.kobv.de/opus4-zib/frontdoor/index/index/docId/588 UR - https://nbn-resolving.org/urn:nbn:de:0297-zib-5887 ER -