TY - JOUR A1 - Chewle, Surahit A1 - Weber, Marcus A1 - Emmerling, Franziska T1 - Revealing Kinetics of Paracetamol Crystallization Using Time-Resolved Raman Spectroscopy, Orthogonal Time-Lapse Photography, and Non-Negative Matrix Factorization (OSANO) T2 - Crystal Growth & Design N2 - Crystallization is a complex phenomenon with far-reaching implications for the production and formulation of active pharmaceutical ingredients. Understanding this process is critical for achieving control over key physicochemical properties that can affect, for example, the bioavailability and stability of a drug. In this study, we were able to reveal intricate and diverse dynamics of the formation of metastable intermediates of paracetamol crystallization varying with the choice of solvent. We demonstrate the efficacy of our novel approach utilizing an objective function-based non-negative matrix factorization technique for the analysis of time-resolved Raman spectroscopy data, in conjunction with time-lapse photography. Furthermore, we emphasize the crucial importance of integrating Raman spectroscopy with supplementary experimental instrumentation for the mathematical analysis of the obtained spectra. Y1 - 2023 UR - https://opus4.kobv.de/opus4-zib/frontdoor/index/index/docId/9228 VL - 23 IS - 9 SP - 6737 EP - 6746 PB - American Chemical Society ER -