TY - GEN A1 - Enciso, Marta A1 - Schütte, Christof A1 - Delle Site, Luigi T1 - Influence of pH and sequence in peptide aggregation via molecular simulation N2 - We employ a recently developed coarse-grained model for peptides and proteins where the effect of pH is automatically included. We explore the effect of pH in the aggregation process of the amyloidogenic peptide KTVIIE and two related sequences, using three different pH environments. Simulations using large systems (24 peptides chains per box) allow us to correctly account for the formation of realistic peptide aggregates. We evaluate the thermodynamic and kinetic implications of changes in sequence and pH upon peptide aggregation, and we discuss how a minimalistic coarse- grained model can account for these details. T3 - ZIB-Report - 15-42 KW - coarse graining KW - peptide aggregation dynamics KW - Monte Carlo Y1 - 2015 UR - https://opus4.kobv.de/opus4-zib/frontdoor/index/index/docId/5580 UR - https://nbn-resolving.org/urn:nbn:de:0297-zib-55805 SN - 1438-0064 ER -