TY - GEN A1 - Harman, Radoslav A1 - Sagnol, Guillaume T1 - Computing D-optimal experimental designs for estimating treatment contrasts under the presence of a nuisance time trend N2 - We prove a mathematical programming characterisation of approximate partial D-optimality under general linear constraints. We use this characterisation with a branch-and-bound method to compute a list of all exact D-optimal designs for estimating a pair of treatment contrasts in the presence of a nuisance time trend up to the size of 24 consecutive trials. T3 - ZIB-Report - 15-02 KW - optimal design of experiments KW - nuisance trend KW - branch and bound Y1 - 2015 UR - https://opus4.kobv.de/opus4-zib/frontdoor/index/index/docId/5364 UR - https://nbn-resolving.org/urn:nbn:de:0297-zib-53640 SN - 1438-0064 ER -