TY - GEN A1 - Erdmann, Bodo A1 - Lang, Jens A1 - Seebass, Martin T1 - Optimization of Temperature Distributions for Regional Hyperthermia Based on a Nonlinear Heat Transfer Model N2 - We describe an optimization process specially designed for regional hyperthermia of deap seated tumors in order to achieve desired steady--state temperature distributions. A nonlinear three--dimensional heat--transfer model based on temperature--dependent blood perfusion is applied to predict the temperature. Optimal heating is obtained by minimizing an integral object function which measures the distance between desired and model predicted temperatures. Sequential minima are calculated from successively improved constant--rate perfusion models employing a damped Newton method in an inner iteration. Numerical results for a Sigma 60 applicator are presented. This work has been supported by Deutsche Forschungsgemeinschaft (DFG) within the Sonderforschungsbereich 273 \glqq Hyperthermie: Methodik und Klinik \grqq . T3 - ZIB-Report - SC-97-59 Y1 - 1997 UR - https://opus4.kobv.de/opus4-zib/frontdoor/index/index/docId/328 UR - https://nbn-resolving.org/urn:nbn:de:0297-zib-3283 ER -