Design and Development of a Bioreactor System for Mechanical Stimulation of Musculoskeletal Tissue

  • We report on the development of a bioreactor system for mechanical stimulation of musculoskeletal tissues. The ultimate object is to improve the quality of medical treatment following injuries of the enthesis tissue. To this end, the tissue formation process through the effect of mechanical stimulation is investigated. A six-well system was designed, 3D printed and tested. An integrated actuator creates strain by applying a force. A contactless position sensor monitors the travels. An electronic circuit controls the bioreactor using a microcontroller. An IoT platform connects the microcontroller to a smartphone, enabling the user to alter variables, trigger actions and monitor the system. The system was stabilised by implementing two PID controllers and safety measures. The results show that the bioreactor design is suited to execute mechanical stimulation and to investigate the tissue formation and regeneration process …

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Metadaten
Author:Theresa Bartel, Jeremy M Mortimer, Waldemar Zylka, Jennifer Paxton, Jan Bernd Vorstius
DOI:https://doi.org/https://doi.org/10.1515/cdbme-2023-1031
Parent Title (English):Current Directions in Biomedical Engineering
Document Type:Article
Language:English
Date of Publication (online):2023/12/21
Date of first Publication:2023/09/01
Publishing Institution:Westfälische Hochschule Gelsenkirchen Bocholt Recklinghausen
Release Date:2024/01/15
Volume:9
Issue:1
First Page:122
Last Page:125
Institutes:Fachbereiche / Elektrotechnik und angewandte Naturwissenschaften
Licence (German):Es gilt das Urheberrechtsgesetz
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