TY - CHAP A1 - König, Britta A1 - Gernhardt, C. A1 - Guberina, Nika A1 - Kühl, Hilmar A1 - Forsting, Michael A1 - Zylka, Waldemar T1 - Suitability of iterative reconstruction for lung-cancer screening with low-dose computer tomography: First results of a phantom study. T2 - European Congress of Radiology 2020 Y1 - 2020 U6 - https://doi.org/10.26044/ecr2020/C-02150 SP - C-02150 ER - TY - JOUR A1 - Bos, Denise A1 - König, Britta A1 - Blex, Sebastian A1 - Zensen, Sebastian A1 - Opitz, Marcel A1 - Maier, Sandra A1 - Forsting, Michael A1 - Zylka, Waldemar A1 - Kühl, Hilmar A1 - Wetter, Axel A1 - Guberina, Nika T1 - Experimental examination of radiation doses from cardiac and liver CT perfusion in a phantom study as a function of organ, age and sex JF - Journal of Radiological Protection N2 - Cardiac and liver computed tomography (CT) perfusion has not been routinely implemented in the clinic and requires high radiation doses. The purpose of this study is to examine the radiation exposure and technical settings for cardiac and liver CT perfusion scans at different CT scanners. Two cardiac and three liver CT perfusion protocols were examined with the N1 LUNGMAN phantom at three multi-slice CT scanners: a single-source (I) and second- (II) and third-generation (III) dual-source CT scanners. Radiation doses were reported for the CT dose index (CTDIvol) and dose–length product (DLP) and a standardised DLP (DLP10cm) for cardiac and liver perfusion. The effective dose (ED10cm) for a standardised scan length of 10 cm was estimated using conversion factors based on the International Commission on Radiological Protection (ICRP) 110 phantoms and tissue-weighting factors from ICRP 103. The proposed total lifetime attributable risk of developing cancer was determined as a function of organ, age and sex for adults. Radiation exposure for CTDIvol, DLP/DLP10 cm and ED10 cm during CT perfusion was distributed as follows: for cardiac perfusion (II) 144 mGy, 1036 mGy·cm/1440 mGy·cm and 39 mSv, and (III) 28 mGy, 295 mGy·cm/279 mGy·cm and 8 mSv; for liver perfusion (I) 225 mGy, 3360 mGy·cm/2249 mGy·cm and 54 mSv, (II) 94 mGy, 1451 mGy·cm/937 mGy·cm and 22 mSv, and (III) 74 mGy, 1096 mGy·cm/739 mGy·cm and 18 mSv. The third-generation dual-source CT scanner applied the lowest doses. Proposed total lifetime attributable risk increased with decreasing age. Even though CT perfusion is a high-dose examination, we observed that new-generation CT scanners could achieve lower doses. There is a strong impact of organ, age and sex on lifetime attributable risk. Further investigations of the feasibility of these perfusion scans are required for clinical implementation. Y1 - 2021 U6 - https://doi.org/10.1088/1361-6498/abf71f SN - 0952-4746 VL - 41 IS - 3 SP - 512 ER - TY - JOUR A1 - Bos, Denise A1 - König, Britta A1 - Blex, Sebastian A1 - Zensen, Sebastian A1 - Opitz, Marcel A1 - Maier, Sandra A1 - Forsting, Michael A1 - Zylka, Waldemar A1 - Kühl, Hilmar A1 - Wetter, Axel A1 - Guberina, Nika T1 - Experimental Examination of Radiation Doses Of Dual-and Single-Energy Computed Tomography in Chest And Upper Abdomen in a Phantom Study JF - Radiation Protection Dosimetry N2 - The aim of this phantom study is to examine radiation doses of dual- and single-energy computed tomography (DECT and SECT) in the chest and upper abdomen for three different multi-slice CT scanners. A total of 34 CT protocols were examined with the phantom N1 LUNGMAN. Four different CT examination types of different anatomic regions were performed both in single- and dual-energy technique: chest, aorta, pulmonary arteries for suspected pulmonary embolism and liver. Radiation doses were examined for the CT dose index CTDIvol and dose-length product (DLP). Radiation doses of DECT were significantly higher than doses for SECT. In terms of CTDIvol, radiation doses were 1.1–3.2 times higher, and in terms of DLP, these were 1.1–3.8 times higher for DECT compared with SECT. The third-generation dual-source CT applied the lowest dose in 7 of 15 different examination types of different anatomic regions. Y1 - 2021 U6 - https://doi.org/10.1093/rpd/ncab052 SN - 0144-8420 VL - 193 IS - 3-4 SP - 237 EP - 246 ER -