- This chapter addresses mathematical models for isothermal mixtures of hydrogen and natural gas, motivated by the need for reliable simulation tools in future low-carbon energy systems. We analyze several classes of mixture models and investigate their convergence properties in the regime of strong interaction between constituents, covering stationary and instationary single-pipe settings as well as network flows. Since mixture models critically depend on the choice of pressure law, we compare the industry-standard GERG equation of state with simplified alternatives that preserve convex energies and reduce computational costs. For network applications, we discuss consistent coupling conditions across model classes, explore optimization of steady flows using the algebraic Weymouth formulation, and provide numerical evidence for its applicability in relevant operating regimes. The study reveals when simplified models are justified and outlines key open challenges for the modeling of gas mixtures.