Refine
Document Type
- Article (30)
- Article in a Periodical of the TH Wildau (14)
- Conference Proceeding (6)
- Master's Thesis (5)
- Report (3)
- Part of a Book (2)
- Bachelor Thesis (1)
- Book (1)
- Doctoral Thesis (1)
- Part of Periodical (1)
Year of publication
- 2019 (66) (remove)
Institute
Has Fulltext
- yes (66)
Keywords
- C60 fullerene (3)
- apoptosis (3)
- leukemic cell (3)
- berberine (2)
- cytotoxicity (2)
- doxorubicin (2)
- 365 nm (1)
- AAL (1)
- Akkreditierung (1)
- Android (1)
Der Beitrag thematisiert die berufliche Fortbildung in Bezug auf den in Wildau seit 2015 angebotenen Masterstudiengang Bibliotheksinformatik und beschreibt, vor welchem Hintergrund man sich bei der Vielzahl an möglichen IT-Skills auf die zehn angebotenen Module fokussiert hat. Er reflektiert kritisch die bisher gewonnenen Erfahrungen aus Sicht der Konstrukteure des Curriculums, aber ebenfalls der Absolventen.
Anthropology meets Library
(2019)
Bibliotheken sind ein ideales Betätigungsfeld für Ethnolog*innen: Sie unterliegen im digitalen Zeitalter einem rapiden Veränderungsdruck hinsichtlich ihrer Serviceangebote, was sich erheblich auf die etablierten Arbeitsweisen und -inhalte der Mitarbeitenden auswirkt. Diese müssen die Grundlage ihrer Arbeit kontinuierlich reflektieren und lernen, auf permanente und sich verstärkende Veränderungstendenzen zu reagieren. Zugleich müssen Bibliotheken auf den gesellschaftlichen Wandel reagieren; dies betrifft sowohl die Alterung der Gesellschaft als auch ihre zunehmende Plurikulturalität. Es gilt, die spezifischen Bedarfe und Denkweisen einer älter und zugleich kulturell diverser werden Nutzerschaft grundlegend zu verstehen, um darauf mit bedarfsgerechten Angeboten antworten zu können. Hier kann die Anwendung ethnologischer Methoden sub stanziell dazu beitragen, mit diesen Herausforderungen angemessen umzugehen. Das wird anhand verschiedener Beispiele aus dem Bereich wissenschaftlicher Bibliotheken exemplarisch dargestellt, wobei diese Beispiele im Kern aber auch auf öffentliche Bibliotheken übertragbar sind. Zugleich kann die ethnologische Befassung mit beruflichen Praktiken und normativen Haltungen im Bereich der Bibliotheken sowie mit den sich unter dem Vorzeichen einer ubiquitären Digitalisierung wandelnden Bedarfen einer alternden und sich kulturell diversifizierenden Gesellschaft prototypisch dazu beitragen, die Angewandte Ethnologie anzureichern mit potenziell generalisierbaren methodologischen und theoretischen Erkenntnissen. Diese erwachsen aus einer exemplarischen Befassung mit Phänomenen, die von universeller Reichweite sind und insoweit über die Domäne des untersuchten Felds der Bibliotheken hinausreichen.
Die internen Abläufe an Hochschulen folgen selten vordefinierten Regeln, sodass bei der Digitalisierung solcher Prozesse Standardlösungen vielfach nicht ausreichen. Für die Abbildung ehemals analoger Prozesse sind individuelle Softwarelösungen unabdingbar. In diesem Kapitel soll am Beispiel ausgewählter hochschulspezifischer Softwareanwendungen der Weg beschrieben werden, wie ein solcher Umbau im Rahmen bestehender Systeme vollzogen werden kann.
Im Fokus dieser Beschreibung stehen Softwareanwendungen, die sowohl die Verwaltungsprozesse rund um die Erstellung von Thesisarbeiten – beginnend mit der Anmeldung bis zur Abgabe der Arbeit, der Durchführung von Abschlussprüfungen bis zur Publikation der Thesisarbeiten – als auch Akkreditierungsprozesse an der TH Wildau unterstützen, mit denen Modulhandbücher und Logbücher erstellt werden, die die Entwicklung von Studiengängen zwischen den Reakkreditierungen transparent nachvollziehbar machen. Ein besonderes Augenmerk wird auf Schnittstellen anderer Hochschulprozesse gelegt.
Diese Anwendungen wurden mit agilen Methoden erstellt. Das Zusammenspiel von agiler Softwareentwicklung und entsprechenden Evaluationsschritten soll zeigen, wie diese Methoden an der Hochschule mit kleinen Teams effektiv eingesetzt werden können, um mit Blick auf die Verbesserung der Qualität und Einheitlichkeit von Studium und Lehre ein bestmögliches Optimierungspotenzial zu erreichen.
Optical fibers in metrology, telecommunications, sensors, manufacturing, and health science have gained massive research interest. The number of applications is increasing at a fast pace. This book aims to present a collection of recent advances in fiber optics, addressing both fundamental and industrial applications. It covers the current progress and latest breakthroughs in emergent applications of fiber optics. The book includes five chapters on recent developments in optical fiber communications and fiber sensors, as well as the design, simulation, and fabrication of novel fiber concepts.
Anthracyclines like daunorubicin (DRN) and doxorubicin (DOX) play an undisputed key role in cancer treatment, but their chronic administration can cause severe side effects. For precise anthracycline analytical systems, aptamers are preferable recognition elements. Here, we describe the detailed characterisation of a single-stranded DNA aptamer DRN-10 and its truncated versions for DOX and DRN detection. Binding affinities were determined from surface plasmon resonance (SPR) and microscale thermophoresis (MST) and combined with conformational data from circular dichroism (CD). Both aptamers displayed similar nanomolar binding affinities to DRN and DOX, even though their rate constants differed as shown by SPR recordings. SPR kinetic data unravelled a two-state reaction model including a 1 : 1 binding and a subsequent conformational change of the binding complex. This model was supported by CD spectra. In addition, the dissociation constants determined with MST were always lower than that from SPR, and especially for the truncated aptamer they differed by two orders of magnitude. This most probably reflects the methodological difference, namely labelling for MST vs. immobilisation for SPR. From CD recordings, we suggested a specific G-quadruplex as structural basis for anthracycline binding. We concluded that the aptamer DRN-10 is a promising recognition element for anthracycline detection systems and further selected aptamers can be also characterised with the combined methodological approach presented here.
Dieser Ausschnitt aus einer Masterarbeit dient der Betrachtung der Aufnahme und Verarbeitung von Informationen durch den Menschen im Straßenverkehr. Dazu werden unter anderem die Prozesse der Informationsaufnahme, Informationsverarbeitung und die Überführung der Informationen in eine Handlung genauer betrachtet, um erkennen zu können, welchen Nutzen Fahrerassistenzsysteme erzielen können, indem sie dem Menschen die Fahraufgabe entweder teilweise oder sogar vollständig abnehmen.
Single Pilot Operations is a current topic with the potential to significantly affect the future of commercial aviation. While financially attractive for airlines, Single Pilot Operations bring forth important safety concerns, especially regarding the lack of human redundancy in the flight deck, an increased workload for the single pilot, reduced situational awareness and a higher risk of human error.
It is assumed that potential problems affecting Single Pilot Operations could be addressed by implementing an Augmented Reality (AR) device in the flight deck, by presenting additional information and supporting hints within the pilot’s field of view. Concretely, AR could be used to help reduce the single pilot’s workload, improve situational awareness and reduce the risk of human error.
This paper sets out to demonstrate two use cases for augmented reality in the flight deck. A system, called Pilot Assist, was developed that allows pilots to conduct checklists interactively with a Microsoft HoloLens. The system also provides a holographic Head-up-Display. Pilot Assist was developed and demonstrated with a fixed base Airbus A320 simulator at the Technical University of Wildau.
With the HoloLens’ spatial mapping capabilities – scanning and recognizing the environment around the user – it was possible to create a system that guides the pilot through the conduction of checklists. This is done by prompting the user towards the location of each checklist item in the cockpit, where information regarding necessary actions is projected. Furthermore, Pilot Assist is integrated with the aircraft systems, making it possible to obtain aircraft status data in real time, thus allowing error-checking of the pilot’s actions as well as automating the progress through checklists.
The holographic Head-up-Display allows the user to look at the surrounding environment while presenting critical flight data within the user’s field of view. The holographic Head-up-Display is intended to contribute to the pilot’s situational awareness.
Experts in the aviation field, including pilots, researchers and engineers had the chance to qualitatively assess the Pilot Assist tool. They pointed to limitations of both Pilot Assist and the HoloLens itself, but shared optimism as to how this technology and similar applications could indeed impact the future of flight operations. Concerns regarding the HoloLens’ weight, comfort and narrow field of view were expressed. However, continued development of head mounted devices (e.g. HoloLens 2) is expected in the coming years.
Further research into augmented reality applications in the flight deck is needed to advance this and other use cases. Nonetheless, the experts agreed Pilot Assist provides beneficial support during single pilot operation considering the current prototypical nature of the system.
The initial opening of China and India coupled with the opening of the former socialist countries in the 1990s led to the integration of 40% of the global labour force into the world economy, causing large-scale effects regarding market integration, catching up, and income distribution. This trend has been defined as ‘Shifting wealth I’ (OECD, 2010, OECD, 2015). However, today, there is some uncertainty as to whether this process will continue, i.e. whether emerging economies will continue their process of technological upgrading and move from efficiency to innovation-driven growth. Whether we will observe ‘Shifting Wealth II’ or the further growth of emerging economies will ultimately depend on whether the productivity growth of emerging economies will be associated with further upgrades in technology. In addition, technology upgrading was, until recently at least, to some extent positively connected with the prevailing liberalized trade regime. Currently there are political developments around the world which represent a threat to the established trade system by way of increasing national protectionism which might impact future upgrading in one way or the other.
Three building blocks have been designed to chemically link to a gold surface and vertically self-assemble through thymine–adenine hydrogen bonds. Starting from these building blocks, two different films were engineered on gold surface. Film 1 consists of adenine linked to lipoic acid (Lipo–A) to covalently bind to the gold surface, and ZnTPP linked to a thymine (T–ZnTPP). Film 2 has an additional noncovalently linked layer: a helical undecapeptide analogue of the trichogin GA IV peptide, in which four glycines were replaced by four lysines to favor a helical conformation and reduce flexibility and the two extremities were functionalized with thymine and adenine to enable Lipo–A and T–ZnTPP binding, respectively. These films were characterized by electrochemical and spectroscopic techniques, and were very stable over time and when in contact with solution. Under illumination, they could generate current with higher efficiency than similar previously described systems.
The isoquinoline quaternary alkaloid Berberine possesses a variety of pharmacological properties that suggests its promising application for an anticancer delivery system design utilizing its ability to intercalate DNA. In the current work, we have investigated the effects of Berberine on the human T cell leukemia cell line in vitro. Fluorescent microscopy of leukemic cells revealed Berberine nuclear localization. The results showed that Berberine inhibited leukemic cell growth in a time- and dose-dependent manner, that was associated with reactive oxygen species production intensification and caspase 3/7 activity increase with followed apoptosis induction. Berberine was used as a toxic and phototoxic agent for triple system synthesis along with DNA as a carrier and nanosilver as a plasmonic accelerator of Berberine electronic transitions and high energy emission absorbent centers. The proposed method allows to obtain the complex of DNA with Berberine molecules and silver nanoparticles. The optical properties of free components as well as their various combinations, including the final triple system DNA-Nanosilver-Berberine, were investigated. Obtained results support the possibility to use the triple system DNA-Nanosilver-Berberine as an alternative therapeutic agent for cancer treatment.