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Blood sampling as well as sample preparation are time consuming and requires a strict procedure, which is generally performed by medical trained personal. Not carrying out the procedure correctly could result in an infection of the patient or contamination of the sample itself. These limitations should be especially considered in case of pandemic outbreaks. In order to handle such a high number of patients a novel sample preparation system paired with modern blood sampling procedure is necessary. For this reason, a new device for blood sampling and preparation is designed containing an integrated microfluidic system. The fabrication is carried out by utilizing micro moulding of PDMS as well as micro milling. A first set of initial experiments as part of a first-generation study shows promising results. However, further steps of optimisation considering flow time and preparation cycle are part of a second-generation study.
The sample preparation for biological and chemical probes involves following a strict workflow to eliminate any contamination to the sample beforehand. Furthermore, it is time consuming and must be carried out by trained personnel such as a nurse or other supervisors, making it therefore expensive. The development of novel sample preparation techniques paired with modern sample analysis systems is focused on improving the operability while keeping a constant quality of results. This is important to analyse samples, which cannot be determined with current screening conditions. The analysis of analytes is required to receive a more detailed picture of the patient and to fully understand its complexity. Possible samples for in-depth analysis of chemical origin can be cholesterol or glucose. More complex samples, such as blood or saliva, require a sophisticated system, which analyses the samples for their individual compounds.
A passive pipe sampler device for contaminant analysis in groundwater was developed which create a permanent sampling flow from groundwater and in addition to temperature, conductivity and pressure, now also has room for specific sorbents. The large surface of the adsorber offers more binding surface for the analyte and the constant movement of the sorbent with fresh groundwater also provides homogeneous binding. The spectroscopic analyses at the monitoring site of the pipe passive sampler for groundwater monitoring points enables a measurement-based validation of the sorbent circulation as an alternative to a visual assessment. The optimum pump speed for the sorbens Lewatit® M500 and SR7 was evaluated. The 42mm slim measuring device allows the use in DN50 monitoring well and thus allows the setup of a closer measuring network.