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Multichannel real-time detection of biomarkers with highly miniaturized photonic microchips

  • The development of novel photonic integrated microchips (PIC) is a promising approach to allow for the convenient detection of key biomarkers in complex matrices through multichannel real-time analysis in a highly compact package. This study reports the successful development and application of a backside released CMOS chip designed for the multichannel real-time detection of biomarkers. Operating at the C-band at approx. 1550 nm, the microchip features three dedicated detection sensors in addition to a reference sensor, enabling simultaneous analysis of multiple biomarkers. The compact and highly miniaturized design of this microchip, with a footprint of just 1 mm², positions it as promising candidate for point-of-care diagnostics and personalized medicine applications. This technology opens a path to transform biomarker detection across various medical fields, offering rapid, reliable, and cost-effective diagnostic solutions. In conclusion, the presented multichannel photonic microchips signify a substantial leap forward in real-time biomarker detection, providing a highly capable platform for future research and clinical applications.

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Metadaten
URN:urn:nbn:de:kobv:526-opus4-20456
Publisher DOI:https://doi.org/10.1117/12.3056453
Author:Robert TannenbergGND, Martin Paul, Tabea Fünning, Christoph Schumann, Michael G. WellerORCiD, Patrick SteglichORCiD
Parent Title (English):Proceedings of SPIE : Optical Sensors 2025
Document Type:Conference Proceeding
Language:English
Year of Publication:2025
Volume:13527
Article Number:135270J
Publisher:SPIE
Faculties an central facilities:Fachbereich Ingenieur- und Naturwissenschaften
Editor:Francesco BaldiniORCiD, Jiri Homola, Robert A. Lieberman
Publishing Institution:Technische Hochschule Wildau
Tag:biochemical sensor; immunosensor; optical biosensor; photonic biosensor; photonic integrated circuit; silicon photonics; surface functionalization
Source:Robert Tannenberg, Martin Paul, Tabea Fünning, Christoph Schumann, Michael G. Weller, and Patrick Steglich "Multichannel real-time detection of biomarkers with highly miniaturized photonic microchips", Proc. SPIE 13527, Optical Sensors 2025, 135270J (23 May 2025); https://doi.org/10.1117/12.3056453
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
6 Technik, Medizin, angewandte Wissenschaften / 62 Ingenieurwissenschaften / 621 Angewandte Physik
Licence (German):Das Dokument ist urheberrechtlich geschützt.
Release Date:2025/06/02
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