Identification of G-quadruplex structures that possess transcriptional regulating functions in the Dele and Cdc6 CpG islands

  • G-quadruplex is a DNA secondary structure that has been shown to play an important role in biological systems. In a previous study, we identified 1998 G-quadruplex-forming sequences using a mouse CpG islands DNA microarray with a fluorescent-labeled G-quadruplex ligand. Among these putative G-quadruplex-forming sequences, G-quadruplex formation was verified for 10 randomly selected sequences by CD spectroscopy and DMS footprinting analysis. In this study, the biological function of the 10 G-quadruplex-forming sequences in the transcriptional regulation has been analyzed using a reporter assay.

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Metadaten
Author:Daniyah H. Bay, Annika Busch, Fred LisdatORCiDGND, Keisuke Iida, Kazunori Ikebukuro, Kazuo Nagasawa, Isao Karube, Wataru Yoshida
URN:urn:nbn:de:kobv:526-opus4-9811
DOI:https://doi.org/10.1186/s12867-017-0094-z
ISSN:1471-2199
Parent Title (English):BMC Molecular Biology
Document Type:Article
Language:English
Year of Publication:2017
Publishing Institution:Technische Hochschule Wildau
Release Date:2017/08/10
Tag:7OTD; Cdc6; Dele; G-quadruplex; Transcriptional regulation
Volume:18
Issue:17
Source:Bay et al. BMC Molecular Biol (2017) 18:17. DOI 10.1186/s12867-017-0094-z
Faculties an central facilities:Fachbereich Ingenieur- und Naturwissenschaften
Dewey Decimal Classification:5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie
Licence (German):Creative Commons - CC BY - Namensnennung 4.0 International
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