SNP microarray analyses reveal copy number alterations and progressive genome reorganization during tumor development in SVT/t driven mice breast cancer

  • Tumor development is known to be a stepwise process involving dynamic changes that affect cellular integrity and cellular behavior. This complex interaction between genomic organization and gene, as well as protein expression is not yet fully understood. Tumor characterization by gene expression analyses is not sufficient, since expression levels are only available as a snapshot of the cell status. So far, research has mainly focused on gene expression profiling or alterations in oncogenes, even though DNA microarray platforms would allow for high-throughput analyses of copy number alterations (CNAs).

Download full text files

Export metadata

Additional Services

Search Google Scholar Statistics
Metadaten
Author:Christoph Standfuß, Heike Pospisil, Andreas Klein
URN:urn:nbn:de:kobv:526-opus4-6414
DOI:https://doi.org/10.1186/1471-2407-12-380
ISSN:1471-2407
Parent Title (English):BMC Cancer
Document Type:Article
Language:English
Year of Publication:2012
Publishing Institution:Technische Hochschule Wildau
Release Date:2016/07/06
Tag:CNV; breast cancer; copy number alteration; fragile sites; genome reorganization
Volume:12
Issue:380
Page Number:15
Source:Standfuß et al.: SNP microarray analyses reveal copy number alterations and progressive genome reorganization during tumor development in SVT/t driven mice breast cancer. BMC Cancer 2012 12:380.
Faculties an central facilities:Fachbereich Ingenieurwesen / Wirtschaftsingenieurwesen (bis 8/2014)
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 616 Krankheiten
Licence (German):Creative Commons - CC BY - Namensnennung 2.0 Generic
Verstanden ✔
Diese Webseite verwendet technisch erforderliche Session-Cookies. Durch die weitere Nutzung der Webseite stimmen Sie diesem zu. Unsere Datenschutzerklärung finden Sie hier.