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One-step selection of Vaccinia virus-binding DNA aptamers by MonoLEX

  • As a new class of therapeutic and diagnostic reagents, more than fifteen years ago RNA and DNA aptamers were identified as binding molecules to numerous small compounds, proteins and rarely even to complete pathogen particles. Most aptamers were isolated from complex libraries of synthetic nucleic acids by a process termed SELEX based on several selection and amplification steps. Here we report the application of a new one-step selection method (MonoLEX) to acquire high-affinity DNA aptamers binding Vaccinia virus used as a model organism for complex target structures.

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Author:Andreas Nitsche, Andreas Kurth, Anna Dunkhorst, Oliver Pänke, Hendrik Sielaff, Wolfgang Junge, Doreen Muth, Frieder W. Scheller, Walter Stöcklein, Claudia Dahmen, Georg Pauli, Andreas Kage
URN:urn:nbn:de:kobv:526-opus4-6246
DOI:https://doi.org/10.1186/1472-6750-7-48
ISSN:1472-6750
Parent Title (English):BMC Biotechnology
Document Type:Article
Language:English
Year of Publication:2007
Publishing Institution:Technische Hochschule Wildau
Release Date:2016/07/04
Volume:7
Issue:48
Page Number:12
Source:A. Nitsche et al. One-step selection of Vaccinia virus-binding DNA aptamers by MonoLEX. BMC Biotechnology 2007, 7:48 doi:10.1186/1472-6750-7-48
Faculties an central facilities:Fachbereich Ingenieurwesen / Wirtschaftsingenieurwesen (bis 8/2014)
Dewey Decimal Classification:5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie
Licence (German):Creative Commons - CC BY - Namensnennung 2.0 Generic
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