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Microsatellite based molecular epidemiology of Leishmania infantum from re-emerging foci of visceral leishmaniasis in Armenia and pilot risk assessment by ecological niche modeling

  • Leishmaniasis is a vector-borne disease caused by protozoan parasites of the genus Leishmania. In Armenia visceral leishmaniasis (VL) is re-emerging since 1999 after a long break of 30 years, with 167 cases recorded until 2019. Molecular diagnosis of VL was implemented only in 2016, and the causative agent was identified as L. infantum. In the present study we expanded the investigation of the causative agent to a characterization at strain level and the identification of its phylogenetic position among the L. infantum genotypes circulating worldwide. This is the first study addressing genetic diversity and population structure of L. infantum in Armenia and in Transcaucasia. Armenia is an extremely interesting region due to its bio-geographic specificities e.g. the high number of different climates in this small mountainous country and the observed high diversity of sand fly species, part of which occurring in very high altitudes. Ecological niche modeling based on registered VL cases and sand fly vectors collected in active VL foci revealed that the risk of further spread of VL is very high due to climate change. Studies of this region should be expanded to enable targeted control measures.

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Author:Katrin KuhlsORCiD, Olga Moskalenko, Anna Sukiasyan, Dezdemonia Manukyan, Gayane Melik-Andreasyan, Liana Atshemyan, Hripsime Apresyan, Margarita V. Strelkova, Anja Jaeschke, Ralf WielandORCiD, Marcus FrohmeORCiDGND, Sofia CortesORCiD, Ara Keshishyan
URN:urn:nbn:de:kobv:526-opus4-14004
DOI:https://doi.org/10.1371/journal.pntd.0009288
ISSN:1935-2735
Parent Title (English):PLoS Neglected Tropical Diseases
Publisher:Public Library of Science (PLoS)
Document Type:Article
Language:English
Year of Publication:2021
Publishing Institution:Technische Hochschule Wildau
Release Date:2021/05/25
Volume:15
Issue:4
First Page:e0009288
Source:Kuhls K, Moskalenko O, Sukiasyan A, Manukyan D, Melik-Andreasyan G, Atshemyan L, et al. (2021) Microsatellite based molecular epidemiology of Leishmania infantum from re-emerging foci of visceral leishmaniasis in Armenia and pilot risk assessment by ecological niche modeling. PLoS Negl Trop Dis 15(4): e0009288. https://doi.org/10.1371/journal.pntd.0009288
Faculties an central facilities:Fachbereich Ingenieur- und Naturwissenschaften
Dewey Decimal Classification:5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie
Licence (German):Creative Commons - CC BY - Namensnennung 4.0 International
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