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A moonlighting role for enzymes of glycolysis in the co-localization of mitochondria and chloroplasts

  • Glycolysis is one of the primordial pathways of metabolism, playing a pivotal role in energy metabolism and biosynthesis. Glycolytic enzymes are known to form transient multi-enzyme assemblies. Here we examine the wider protein-protein interactions of plant glycolytic enzymes and reveal a moonlighting role for specific glycolytic enzymes in mediating the co-localization of mitochondria and chloroplasts. Knockout mutation of phosphoglycerate mutase or enolase resulted in a significantly reduced association of the two organelles. We provide evidence that phosphoglycerate mutase and enolase form a substrate-channelling metabolon which is part of a larger complex of proteins including pyruvate kinase. These results alongside a range of genetic complementation experiments are discussed in the context of our current understanding of chloroplast-mitochondrial interactions within photosynthetic eukaryotes.

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Metadaten
Author:Youjun Zhang, Arun Sampathkumar, Sandra Mae-Lin Kerber, Corné Swart, Carsten HilleORCiD, Kumar Seerangan, Alexander Graf, Lee Sweetlove, Alisdair R. Fernie
URN:urn:nbn:de:kobv:526-opus4-14812
DOI (Version of Record):https://doi.org/10.1038/s41467-020-18234-w
ISSN:2041-1723
Parent Title (English):Nature Communications
Document Type:Article
Language:English
Year of Publication:2020
Publishing Institution:Technische Hochschule Wildau
Release Date:2021/09/03
Volume:11
First Page:4509
Source:Zhang, Y., Sampathkumar, A., Kerber, S.ML. et al. A moonlighting role for enzymes of glycolysis in the co-localization of mitochondria and chloroplasts. Nat Commun 11, 4509 (2020). https://doi.org/10.1038/s41467-020-18234-w
Faculties an central facilities:Zentrale Einrichtungen
Dewey Decimal Classification:5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie
Licence (German):Creative Commons - CC BY - Namensnennung 4.0 International
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