Integrated pathway modules using time-course metabolic profiles and EST data from Milnesium tardigradum
- Tardigrades are multicellular organisms, resistant to extreme environmental changes such as heat, drought, radiation and freezing. They outlast these conditions in an inactive form (tun) to escape damage to cellular structures and cell death. Tardigrades are apparently able to prevent or repair such damage and are therefore a crucial model organism for stress tolerance. Cultures of the tardigrade Milnesium tardigradum were dehydrated by removing the surrounding water to induce tun formation. During this process and the subsequent rehydration, metabolites were measured in a time series by GC-MS. Additionally expressed sequence tags are available, especially libraries generated from the active and inactive state. The aim of this integrated analysis is to trace changes in tardigrade metabolism and identify pathways responsible for their extreme resistance against physical stress.
Author: | Daniela Beisser, Markus GrohmeGND, Joachim Kopka, Marcus FrohmeORCiDGND, Ralph O. Schill, Steffen Hengherr, Thomas DandekarORCiDGND, Gunnar W. Klau, Marcus Dittrich, Tobias Müller |
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URN: | urn:nbn:de:kobv:526-opus4-6146 |
DOI: | https://doi.org/10.1186/1752-0509-6-72 |
ISSN: | 1752-0509 |
Parent Title (English): | BMC Systems Biology |
Document Type: | Article |
Language: | English |
Year of Publication: | 2012 |
Publishing Institution: | Technische Hochschule Wildau |
Release Date: | 2016/06/30 |
Tag: | functional modules; integrated network analysis; metabolic pathways; metabolic profiles; trend test |
Volume: | 6 |
Issue: | 72 |
Page Number: | 13 |
Source: | Beisser et al.:Integrated pathway modules using time-course metabolic profiles and EST data from Milnesium tardigradum. BMC Systems Biology 2012 6:72. |
Faculties an central facilities: | Fachbereich Ingenieurwesen / Wirtschaftsingenieurwesen (bis 8/2014) |
Dewey Decimal Classification: | 5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie |
Licence (German): | Creative Commons - CC BY - Namensnennung 2.0 Generic |