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Toxicity of Water-Soluble D-g-PNIPAM Polymers in a Complex with Chemotherapy Drugs and Mechanism of Their Action In Vitro

  • The application of a biocompatible polymer nanocarrier can provide target delivery to tumor tissues, improved pharmacokinetics, controlled drug release, etc. Therefore, the proposed strategy was to use the water-soluble star-like copolymers with a Dextran core and Poly(N-isopropylacrylamide) grafts (D-g-PNIPAM) for conjugation with the widely used chemotherapy drugs in oncology–Cisplatin (Cis-Pt) and Doxorubicin (Dox). The molecular characteristics of the copolymer were received using size-exclusion chromatography. The physicochemical characterization of the D-g-PNIPAM-Cis-Pt (or Dox) nanosystem was conducted using dynamic light scattering and FTIR spectroscopy. Using traditional biochemical methods, a comparative analysis of the enhancement of the cytotoxic effect of free Cis-Pt and Dox in combination with D-g-PNIPAM copolymers was performed in cancer cells of the Lewis lung carcinoma line, which are both sensitive and resistant to Dox; in addition, the mechanism of their action in vitro was evaluated.

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Author:Svitlana PrylutskaORCiD, Anna GrebinykORCiD, Stanislav Ponomarenko, Defne Gövem, Vasyl Chumachenko, Nataliya KutsevolORCiD, Mykola Petrovsky, Uwe RitterORCiD, Marcus FrohmeORCiDGND, Jacek PiosikORCiD, Yuriy PrylutskyyORCiD
URN:urn:nbn:de:kobv:526-opus4-18790
DOI (Version of Record):https://doi.org/10.3390/ijms25053069
ISSN:1422-0067
Parent Title (English):International Journal of Molecular Sciences
Publisher:MDPI
Document Type:Article
Language:English
Year of Publication:2024
Publishing Institution:Technische Hochschule Wildau
Release Date:2024/03/07
Tag:Lewis lung carcinoma; cytotoxicity; drug; star-like copolymer
Volume:25
Issue:5
Article Number:3069
Source:Prylutska, S.; Grebinyk, A.; Ponomarenko, S.; Gövem, D.; Chumachenko, V.; Kutsevol, N.; Petrovsky, M.; Ritter, U.; Frohme, M.; Piosik, J.; et al. Toxicity of Water-Soluble D-g-PNIPAM Polymers in a Complex with Chemotherapy Drugs and Mechanism of Their Action In Vitro. Int. J. Mol. Sci. 2024, 25, 3069. https://doi.org/10.3390/ijms25053069
Faculties an central facilities:Fachbereich Ingenieur- und Naturwissenschaften
Dewey Decimal Classification:5 Naturwissenschaften und Mathematik / 54 Chemie / 547 Organische Chemie
6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 615 Pharmakologie, Therapeutik
Licence (German):Creative Commons - CC BY - Namensnennung 4.0 International
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