Svitlana Prylutska, Anna Grebinyk, Stanislav Ponomarenko, Defne Gövem, Vasyl Chumachenko, Nataliya Kutsevol, Mykola Petrovsky, Uwe Ritter, Marcus Frohme, Jacek Piosik, Yuriy Prylutskyy
- The application of a biocompatible polymer nanocarrier can provide target delivery to tumor tissues, improved pharmacokinetics, controlled drug release, etc. Therefore, the proposed strategy was to use the water-soluble star-like copolymers with a Dextran core and Poly(N-isopropylacrylamide) grafts (D-g-PNIPAM) for conjugation with the widely used chemotherapy drugs in oncology–Cisplatin (Cis-Pt) and Doxorubicin (Dox). The molecular characteristics of the copolymer were received using size-exclusion chromatography. The physicochemical characterization of the D-g-PNIPAM-Cis-Pt (or Dox) nanosystem was conducted using dynamic light scattering and FTIR spectroscopy. Using traditional biochemical methods, a comparative analysis of the enhancement of the cytotoxic effect of free Cis-Pt and Dox in combination with D-g-PNIPAM copolymers was performed in cancer cells of the Lewis lung carcinoma line, which are both sensitive and resistant to Dox; in addition, the mechanism of their action in vitro was evaluated.
MetadatenAuthor: | Svitlana PrylutskaORCiD, Anna GrebinykORCiD, Stanislav Ponomarenko, Defne Gövem, Vasyl Chumachenko, Nataliya KutsevolORCiD, Mykola Petrovsky, Uwe RitterORCiD, Marcus FrohmeORCiDGND, Jacek PiosikORCiD, Yuriy PrylutskyyORCiD |
---|
URN: | urn:nbn:de:kobv:526-opus4-18790 |
---|
DOI (Version of Record): | https://doi.org/10.3390/ijms25053069 |
---|
ISSN: | 1422-0067 |
---|
Parent Title (English): | International Journal of Molecular Sciences |
---|
Publisher: | MDPI |
---|
Document Type: | Article |
---|
Language: | English |
---|
Year of Publication: | 2024 |
---|
Publishing Institution: | Technische Hochschule Wildau |
---|
Release Date: | 2024/03/07 |
---|
Tag: | Lewis lung carcinoma; cytotoxicity; drug; star-like copolymer |
---|
Volume: | 25 |
---|
Issue: | 5 |
---|
Article Number: | 3069 |
---|
Source: | Prylutska, S.; Grebinyk, A.; Ponomarenko, S.; Gövem, D.; Chumachenko, V.; Kutsevol, N.; Petrovsky, M.; Ritter, U.; Frohme, M.; Piosik, J.; et al. Toxicity of Water-Soluble D-g-PNIPAM Polymers in a Complex with Chemotherapy Drugs and Mechanism of Their Action In Vitro. Int. J. Mol. Sci. 2024, 25, 3069. https://doi.org/10.3390/ijms25053069 |
---|
Faculties an central facilities: | Fachbereich Ingenieur- und Naturwissenschaften |
---|
Dewey Decimal Classification: | 5 Naturwissenschaften und Mathematik / 54 Chemie / 547 Organische Chemie |
---|
| 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 615 Pharmakologie, Therapeutik |
---|
Licence (German): | Creative Commons - CC BY - Namensnennung 4.0 International |
---|