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LED-based portable light source for photodynamic therapy

  • Photodynamic therapy (PDT) employs light activation of tissue-localized photosensitizer in an oxygen-dependent process which initiates oxidative stress, inflammation, and cell death. Laser systems, which are mostly used in PDT as light sources can be costly and oversized. light-emitting diodes (LEDs) equipment has a high potential to simplify technical part of phototriggered therapies and to reduce its costs. We develop the LED-based system that includes the control and irradiation units. The system provides the same power density at any irradiation point. Among the advantages of the device is a possibility to change the irradiation area and tune the irradiation dose. PDT experiments with cancer cells in vitro treated with two different photosensitizers demonstrated a possibility to use the developed LED-based system as a low-cost light source in PDT.

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Author:Oksana Chepurna, Anna GrebinykORCiD, Yulia Petrushko, Svitlana PrylutskaORCiD, Sergii GrebinykORCiD, Valeriy Yashchuk, Olga Matyshevska, Uwe RitterORCiD, Thomas DandekarORCiDGND, Marcus FrohmeORCiDGND, Junle Qu, Tymish Y. Ohulchanskyy
URN:urn:nbn:de:kobv:526-opus4-14778
DOI (Version of Record):https://doi.org/10.1117/12.2541774
Document Type:Conference Proceeding
Language:English
Year of Publication:2019
Publishing Institution:Technische Hochschule Wildau
Release Date:2021/08/26
Tag:high power single chip LED; light source; photodynamic therapy
Article Number:111901A
Source:O. Chepurna, A. Grebinyk, Yu. Petrushko, S. Prylutska, S. Grebinyk, V. M. Yashchuk, O. Matyshevska, U. Ritter, T. Dandekar, M. Frohme, J. Qu, and T. Y. Ohulchanskyy, "LED-based portable light source for photodynamic therapy", Proc. SPIE 11190, Optics in Health Care and Biomedical Optics IX, 111901A (20 November 2019); https://doi.org/10.1117/12.2541774
Copyright:Copyright 2019 Society of Photo-Optical Instrumentation Engineers (SPIE). One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited.
Faculties an central facilities:Fachbereich Ingenieur- und Naturwissenschaften
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 62 Ingenieurwissenschaften / 621 Angewandte Physik
Licence (German):Das Dokument ist urheberrechtlich geschützt
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