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Silent Death by Sound: C60 Fullerene Sonodynamic Treatment of Cancer Cells

  • The acoustic pressure waves of ultrasound (US) not only penetrate biological tissues deeper than light, but they also generate light emission, termed sonoluminescence. This promoted the idea of its use as an alternative energy source for photosensitizer excitation. Pristine C60 fullerene (C60), an excellent photosensitizer, was explored in the frame of cancer sonodynamic therapy (SDT). For that purpose, we analyzed C60 effects on human cervix carcinoma HeLa cells in combination with a low-intensity US treatment. The time-dependent accumulation of C60 in HeLa cells reached its maximum at 24 h (800 ± 66 ng/106 cells). Half of extranuclear C60 is localized within mitochondria. The efficiency of the C60 nanostructure’s sonoexcitation with 1 MHz US was tested with cell-based assays. A significant proapoptotic sonotoxic effect of C60 was found for HeLa cells. C60′s ability to induce apoptosis of carcinoma cells after sonoexcitation with US provides a promising novel approach for cancer treatment.

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Metadaten
Author:Aleksandar Radivoievych, Benjamin Kolp, Sergii GrebinykORCiD, Svitlana PrylutskaORCiD, Uwe RitterORCiD, Oliver Zolk, Jörn GlöklerORCiD, Marcus FrohmeORCiDGND, Anna GrebinykORCiD
URN:urn:nbn:de:kobv:526-opus4-16877
DOI (Version of Record):https://doi.org/10.3390/ijms24021020
ISSN:1422-0067
Parent Title (English):International Journal of Molecular Sciences
Publisher:MDPI
Document Type:Article
Language:English
Year of Publication:2023
Publishing Institution:Technische Hochschule Wildau
Release Date:2023/01/09
Tag:C60 fullerene; HeLa cells; apoptosis; sonodynamic therapy; ultrasound
Volume:24
Issue:2
Article Number:1020
Source:Radivoievych, A.; Kolp, B.; Grebinyk, S.; Prylutska, S.; Ritter, U.; Zolk, O.; Glökler, J.; Frohme, M.; Grebinyk, A. Silent Death by Sound: C60 Fullerene Sonodynamic Treatment of Cancer Cells. Int. J. Mol. Sci. 2023, 24, 1020. https://doi.org/10.3390/ijms24021020
Faculties an central facilities:Fachbereich Ingenieur- und Naturwissenschaften
Dewey Decimal Classification:5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie
6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 616 Krankheiten
Funding:Publikationsfonds der TH Wildau
Licence (German):Creative Commons - CC BY - Namensnennung 4.0 International
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