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Variation of butyrate production in the gut microbiome in type 2 diabetes patients

  • Background Diabetes mellitus type 2 is a common disease that poses a challenge to the healthcare system. The disease is very often diagnosed late. A better understanding of the relationship between the gut microbiome and type 2 diabetes can support early detection and form an approach for therapies. Microbiome analysis offers a potential opportunity to find markers for this disease. Next-generation sequencing methods can be used to identify the bacteria present in the stool sample and to generate a microbiome profile through an analysis pipeline. Statistical analysis, e.g., using Student’s t-test, allows the identification of significant differences. The investigations are not only focused on single bacteria, but on the determination of a comprehensive profile. Also, the consideration of the functional microbiome is included in the analyses. The dataset is not from a clinical survey, but very extensive. Results By examining 946 microbiome profiles of diabetes mellitus type 2 sufferers (272) and healthy control persons (674), a large number of significant genera (25) are revealed. It is possible to identify a large profile for type 2 diabetes disease. Furthermore, it is shown that the diversity of bacteria per taxonomic level in the group of persons with diabetes mellitus type 2 is significantly reduced compared to a healthy control group. In addition, six pathways are determined to be significant for type 2 diabetes describing the fermentation to butyrate. These parameters tend to have high potential for disease detection. Conclusions With this investigation of the gut microbiome of persons with diabetes type 2 disease, we present significant bacteria and pathways characteristic of this disease.

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Metadaten
Author:Julienne SiptrothORCiD, Olga Moskalenko, Carsten Krumbiegel, Jörg Ackermann, Ina Koch, Heike Pospisil
URN:urn:nbn:de:kobv:526-opus4-17802
DOI (Version of Record):https://doi.org/10.1007/s10123-023-00324-6
Parent Title (English):International Microbiology
Publisher:Springer Nature
Document Type:Article
Language:English
Year of Publication:2023
Publishing Institution:Technische Hochschule Wildau
Release Date:2023/08/02
Tag:NGS; butyrate; gut; statistical analysis; type 2 diabetes
Volume:26
First Page:601
Last Page:610
Source:Siptroth, J., Moskalenko, O., Krumbiegel, C. et al. Variation of butyrate production in the gut microbiome in type 2 diabetes patients. Int Microbiol 26, 601–610 (2023). https://doi.org/10.1007/s10123-023-00324-6
Faculties an central facilities:Fachbereich Ingenieur- und Naturwissenschaften
Dewey Decimal Classification:5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie
6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 616 Krankheiten
Funding:Projekt DEAL
Licence (German):Creative Commons - CC BY - Namensnennung 4.0 International
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