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Plano-concave optical sensor for transcranial photoacoustic measurements

  • Biomedical photoacoustics is usually used to image absorption-based contrast in soft tissues up to depths of several centimeters and with sub-millimeter resolution. By contrast, measuring Photoacoustic (PA) signals through hard bone tissue shows severe signal degradation due to aberration and high attenuation of high frequency acoustic signal components. This is particularly noticeable when measuring through thicker, human, skull bone. Which is the main reason why transcranial PA imaging in humans has so far proved challenging to implement. To tackle this challenge, we developed an optical resonator sensor based on a previous planar-concave design. This sensor was found to be highly suitable for measuring the low-pressure amplitude and low acoustic frequency signals that are transmitted through human cranial bone. A plano-concave optical resonator sensor was fabricated to provide high sensitivity in the acoustic frequency range of DC to around 2 MHz, a low noise equivalent pressure and a small active element size enabling it to significantly outperform conventional piezoelectric transducers when measuring PA waves transmitted through ex vivo human cranial bones.

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Metadaten
Author:Thomas KirchnerORCiD, Claus VillringerORCiD, Marko Gutke, Jan LauferORCiD
URN:urn:nbn:de:kobv:526-opus4-17840
DOI (Version of Record):https://doi.org/10.1117/12.2675593
Parent Title (English):Opto-Acoustic Methods and Applications in Biophotonics VI
Publisher:Society of Photo-Optical Instrumentation Engineers (SPIE)
Document Type:Conference Proceeding
Language:English
Year of Publication:2023
Publishing Institution:Technische Hochschule Wildau
Release Date:2023/08/31
Tag:brain; ex vivo; human; optical resonator; optoacoustic; photoacoustic; transcranial
Article Number:126310R
Source:Thomas Kirchner, Claus Villringer, Marko Gutke, and Jan Laufer "Plano-concave optical sensor for transcranial photoacoustic measurements", Proc. SPIE 12631, Opto-Acoustic Methods and Applications in Biophotonics VI, 126310R (11 August 2023). DOI: https://doi.org/10.1117/12.2675593
Copyright:Copyright 2023 Society of Photo‑Optical Instrumentation Engineers (SPIE). One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this publication for a fee or for commercial purposes, and modification of the contents of the publication are prohibited.
Faculties an central facilities:Fachbereich Ingenieur- und Naturwissenschaften
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 62 Ingenieurwissenschaften / 621 Angewandte Physik
Licence (German):Das Dokument ist urheberrechtlich geschützt
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