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Synergy of Chemo- and Photodynamic Therapies with C60 Fullerene-Doxorubicin Nanocomplex

  • A nanosized drug complex was explored to improve the efficiency of cancer chemotherapy, complementing it with nanodelivery and photodynamic therapy. For this, nanomolar amounts of a non-covalent nanocomplex of Doxorubicin (Dox) with carbon nanoparticle C60 fullerene (C60) were applied in 1:1 and 2:1 molar ratio, exploiting C60 both as a drug-carrier and as a photosensitizer. The fluorescence microscopy analysis of human leukemic CCRF-CEM cells, in vitro cancer model, treated with nanocomplexes showed Dox’s nuclear and C60’s extranuclear localization. It gave an opportunity to realize a double hit strategy against cancer cells based on Dox’s antiproliferative activity and C60’s photoinduced pro-oxidant activity. When cells were treated with 2:1 C60-Dox and irradiated at 405 nm the high cytotoxicity of photo-irradiated C60-Dox enabled a nanomolar concentration of Dox and C60 to efficiently kill cancer cells in vitro. The high pro-oxidant and pro-apoptotic efficiency decreased IC50 16, 9 and 7 × 103-fold, if compared with the action of Dox, non-irradiated nanocomplex, and C60’s photodynamic effect, correspondingly. Hereafter, a strong synergy of therapy arising from the combination of C60-mediated Dox delivery and C60 photoexcitation was revealed. Our data indicate that a combination of chemo- and photodynamic therapies with C60-Dox nanoformulation provides a promising synergetic approach for cancer treatment.

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Metadaten
Author:Anna GrebinykORCiD, Svitlana PrylutskaORCiD, Oksana Chepurna, Sergii GrebinykORCiD, Yuriy PrylutskyyORCiD, Uwe RitterORCiD, Tymish Y. Ohulchanskyy, Olga Matyshevska, Thomas DandekarORCiDGND, Marcus FrohmeORCiDGND
URN:urn:nbn:de:kobv:526-opus4-12940
DOI:https://doi.org/10.3390/nano9111540
ISSN:2079-4991
Parent Title (English):Nanomaterials
Publisher:MDPI
Document Type:Article
Language:English
Year of Publication:2019
Date of first Publication:2019/10/30
Publishing Institution:Technische Hochschule Wildau
Release Date:2019/12/18
Tag:C60 fullerene; Doxorubicin; apoptosis; leukemic cells; nanocomplex; photodynamic chemotherapy; synergistic effect
Volume:9
Issue:11
Source:Grebinyk, A., Prylutska, S., Chepurna, O., Grebinyk, S., Prylutskyy, Y., Ritter, U., et al. (2019). Synergy of Chemo- and Photodynamic Therapies with C60 Fullerene-Doxorubicin Nanocomplex Nanomaterials. 9 (11), 1540.
Faculties an central facilities:Fachbereich Ingenieur- und Naturwissenschaften
Dewey Decimal Classification:5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie
Funding:DFG-geförderter Publikationsfonds
Licence (German):Creative Commons - CC BY - Namensnennung 4.0 International
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