Xiangkun Li, Zohrab Amirkhanyan, Anna Grebinyk, Matthias Gross, Yuliia Komar, Felix Riemer, Aida Asoyan, Prach Boonpornprasert, Paul Borchert, Hakob Davtyan, Dmytro Dmytriiev, Marcus Frohme, Andreas Hoffmann, Mikhail Krasilnikov, Gregor Loisch, Zahra Lotfi, Frieder Müller, Michael Schmitz, Frank Obier, Anne Oppelt, Sebastian Philipp, Christopher Richard, Grygorii Vashchenko, Daniel Villani, Steven Worm, Frank Stephan
- Objective. The photo injector test facility at DESY in Zeuthen (PITZ) is building up an R&D platform, known as FLASHlab@PITZ, for systematically studying the FLASH effect in cancer treatment with its high-brightness electron beams, which can provide a uniquely large dose parameter range for radiation experiments. In this paper, we demonstrate the capabilities by experiments with a reduced parameter range on a startup beamline and study the potential performance of the full beamline by simulations. Approach. To measure the dose, Gafchromic films are installed both in front of and after the samples; Monte Carlo simulations are conducted to predict the dose distribution during beam preparation and help understand the dose distribution inside the sample. Plasmid DNA is irradiated under various doses at conventional and ultra-high dose rate (UHDR) to study the DNA damage by radiations. Start-to-end simulations are performed to verify the performance of the full beamline. Main results. On the startup beamline, reproducible irradiation has been established with optimized electron beams and the delivered dose distributions have been measured with Gafchromic films and compared to FLUKA simulations. The functionality of this setup has been further demonstrated in biochemical experiments at conventional dose rate of 0.05 Gy s−1 and UHDR of several 105 Gy s−1 and a varying dose up to 60 Gy, with the UHDR experiments finished within a single RF pulse (less than 1 millisecond); the observed conformation yields of the irradiated plasmid DNA revealed its dose-dependent radiation damage. The upgrade to the full FLASHlab@PITZ beamline is justified by simulations with homogeneous radiation fields generated by both pencil beam scanning and scattering beams. Significance. With the demonstration of UHDR irradiation and the simulated performance of the new beamline, FLASHlab@PITZ will serve as a powerful platform for studying the FLASH effects in cancer treatment.
Metadaten| URN: | urn:nbn:de:kobv:526-opus4-20092 |
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| Publisher DOI: | https://doi.org/10.1088/1361-6560/adb276 |
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| Author: | Xiangkun LiORCiD, Zohrab Amirkhanyan, Anna GrebinykORCiD, Matthias GrossORCiD, Yuliia KomarORCiD, Felix RiemerORCiD, Aida AsoyanORCiD, Prach BoonpornprasertORCiD, Paul BorchertORCiD, Hakob DavtyanORCiD, Dmytro DmytriievORCiD, Marcus FrohmeORCiDGND, Andreas HoffmannORCiD, Mikhail KrasilnikovORCiD, Gregor LoischORCiD, Zahra LotfiORCiD, Frieder Müller, Michael Schmitz, Frank Obier, Anne OppeltORCiD, Sebastian Philipp, Christopher Richard, Grygorii VashchenkoORCiD, Daniel VillaniORCiD, Steven WormORCiD, Frank StephanORCiD |
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| Parent Title (English): | Physics in Medicine & Biology |
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| Document Type: | Article |
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| Language: | English |
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| Year of Publication: | 2025 |
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| Volume: | 70 |
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| Issue: | 5 |
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| Article Number: | 055010 |
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| Publisher: | Institute of Physics Publishing (IOP) |
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| Publishing Institution: | Technische Hochschule Wildau |
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| Tag: | FLASH effect; FLASHlab@PITZ; electron beams; ultra-high dose rate |
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| Source: | X-K Li et al 2025 Phys. Med. Biol. 70 055010 |
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| Faculties an central facilities: | Fachbereich Ingenieur- und Naturwissenschaften |
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| Dewey Decimal Classification: | 5 Naturwissenschaften und Mathematik / 53 Physik / 539 Moderne Physik |
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| 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 615 Pharmakologie, Therapeutik |
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| Licence (German): | Creative Commons - CC BY - Namensnennung 4.0 International |
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| Release Date: | 2025/02/27 |
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