Überblick Statistik: Seitenaufrufe (grau) und PDF-Downloads (blau)

From 2D to 3D In Vitro World: Sonodynamically-Induced Prooxidant Proapoptotic Effects of C60-Berberine Nanocomplex on Cancer Cells

  • Recently, sonodynamic therapy (SDT) has emerged as a promising non-invasive approach for treating cancer by activating sensitizers with ultrasound (US). In this context, we investigated C60 fullerene (C60) as a nanocarrier for the promising drug Berberine (Ber)—both potential aromatic sonosensitizers. The preferential mitochondrial accumulation of C60 and the proapoptotic effects of Ber also make the C60-Berberine nanocomplex (C60-Ber) a good candidate for direct induction of the intrinsic apoptotic cell death under US action. The in vitro research on C60-Ber can provide insights into novel, non-invasive cancer treatments. These findings lead to the development of targeted therapies with reduced side effects, inspire interdisciplinary collaboration, and open new avenues for drug delivery and cancer therapy research.

Download full text files

Export metadata

Additional Services

Search Google Scholar Statistics
Metadaten
Author:Aleksandar RadivoievychORCiD, Sophia Schnepel, Svitlana PrylutskaORCiD, Uwe RitterORCiD, Oliver ZolkORCiD, Marcus FrohmeORCiDGND, Anna GrebinykORCiD
URN:urn:nbn:de:kobv:526-opus4-19438
DOI (Version of Record):https://doi.org/10.3390/cancers16183184
Parent Title (English):Cancers
Document Type:Article
Language:English
Year of Publication:2024
Publishing Institution:Technische Hochschule Wildau
Release Date:2024/10/02
Tag:Berberine; C60 fullerene; apoptosis; sonodynamic therapy; ultrasound
Volume:16
Issue:18
Article Number:3184
Source:Radivoievych, A.; Schnepel, S.; Prylutska, S.; Ritter, U.; Zolk, O.; Frohme, M.; Grebinyk, A. From 2D to 3D In Vitro World: Sonodynamically-Induced Prooxidant Proapoptotic Effects of C60-Berberine Nanocomplex on Cancer Cells. Cancers 2024, 16, 3184. https://doi.org/10.3390/cancers16183184
Faculties an central facilities:Fachbereich Ingenieur- und Naturwissenschaften
Dewey Decimal Classification:5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 571 Physiologie und verwandte Themen
6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 616 Krankheiten
Funding:Publikationsfonds der TH Wildau
Licence (German):Creative Commons - CC BY - Namensnennung 4.0 International
Verstanden ✔
Diese Webseite verwendet technisch erforderliche Session-Cookies. Durch die weitere Nutzung der Webseite stimmen Sie diesem zu. Unsere Datenschutzerklärung finden Sie hier.