From 2D to 3D In Vitro World: Sonodynamically-Induced Prooxidant Proapoptotic Effects of C60-Berberine Nanocomplex on Cancer Cells
- Recently, sonodynamic therapy (SDT) has emerged as a promising non-invasive approach for treating cancer by activating sensitizers with ultrasound (US). In this context, we investigated C60 fullerene (C60) as a nanocarrier for the promising drug Berberine (Ber)—both potential aromatic sonosensitizers. The preferential mitochondrial accumulation of C60 and the proapoptotic effects of Ber also make the C60-Berberine nanocomplex (C60-Ber) a good candidate for direct induction of the intrinsic apoptotic cell death under US action. The in vitro research on C60-Ber can provide insights into novel, non-invasive cancer treatments. These findings lead to the development of targeted therapies with reduced side effects, inspire interdisciplinary collaboration, and open new avenues for drug delivery and cancer therapy research.
| URN: | urn:nbn:de:kobv:526-opus4-19438 |
|---|---|
| Publisher DOI: | https://doi.org/10.3390/cancers16183184 |
| Author: | Aleksandar RadivoievychORCiD, Sophia Schnepel, Svitlana PrylutskaORCiD, Uwe RitterORCiD, Oliver ZolkORCiD, Marcus FrohmeORCiDGND, Anna GrebinykORCiD |
| Parent Title (English): | Cancers |
| Document Type: | Article |
| Language: | English |
| Year of Publication: | 2024 |
| Volume: | 16 |
| Issue: | 18 |
| Article Number: | 3184 |
| Publishing Institution: | Technische Hochschule Wildau |
| Tag: | C60 fullerene; apoptosis; berberine; sonodynamic therapy; ultrasound |
| Source: | Radivoievych, A.; Schnepel, S.; Prylutska, S.; Ritter, U.; Zolk, O.; Frohme, M.; Grebinyk, A. From 2D to 3D In Vitro World: Sonodynamically-Induced Prooxidant Proapoptotic Effects of C60-Berberine Nanocomplex on Cancer Cells. Cancers 2024, 16, 3184. https://doi.org/10.3390/cancers16183184 |
| Faculties an central facilities: | Fachbereich Ingenieur- und Naturwissenschaften |
| Dewey Decimal Classification: | 5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 571 Physiologie und verwandte Themen |
| 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 616 Krankheiten | |
| Funding: | Publikationsfonds der TH Wildau |
| Licence (German): | Creative Commons - CC BY - Namensnennung 4.0 International |
| Release Date: | 2024/10/02 |


