From 2D to 3D In Vitro World: Sonodynamically-Induced Prooxidant Proapoptotic Effects of C60-Berberine Nanocomplex on Cancer Cells
- Recently, sonodynamic therapy (SDT) has emerged as a promising non-invasive approach for treating cancer by activating sensitizers with ultrasound (US). In this context, we investigated C60 fullerene (C60) as a nanocarrier for the promising drug Berberine (Ber)—both potential aromatic sonosensitizers. The preferential mitochondrial accumulation of C60 and the proapoptotic effects of Ber also make the C60-Berberine nanocomplex (C60-Ber) a good candidate for direct induction of the intrinsic apoptotic cell death under US action. The in vitro research on C60-Ber can provide insights into novel, non-invasive cancer treatments. These findings lead to the development of targeted therapies with reduced side effects, inspire interdisciplinary collaboration, and open new avenues for drug delivery and cancer therapy research.
Author: | Aleksandar RadivoievychORCiD, Sophia Schnepel, Svitlana PrylutskaORCiD, Uwe RitterORCiD, Oliver ZolkORCiD, Marcus FrohmeORCiDGND, Anna GrebinykORCiD |
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URN: | urn:nbn:de:kobv:526-opus4-19438 |
DOI (Version of Record): | https://doi.org/10.3390/cancers16183184 |
Parent Title (English): | Cancers |
Document Type: | Article |
Language: | English |
Year of Publication: | 2024 |
Publishing Institution: | Technische Hochschule Wildau |
Release Date: | 2024/10/02 |
Tag: | Berberine; C60 fullerene; apoptosis; sonodynamic therapy; ultrasound |
Volume: | 16 |
Issue: | 18 |
Article Number: | 3184 |
Source: | Radivoievych, A.; Schnepel, S.; Prylutska, S.; Ritter, U.; Zolk, O.; Frohme, M.; Grebinyk, A. From 2D to 3D In Vitro World: Sonodynamically-Induced Prooxidant Proapoptotic Effects of C60-Berberine Nanocomplex on Cancer Cells. Cancers 2024, 16, 3184. https://doi.org/10.3390/cancers16183184 |
Faculties an central facilities: | Fachbereich Ingenieur- und Naturwissenschaften |
Dewey Decimal Classification: | 5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 571 Physiologie und verwandte Themen |
6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 616 Krankheiten | |
Funding: | Publikationsfonds der TH Wildau |
Licence (German): | Creative Commons - CC BY - Namensnennung 4.0 International |