Silent Death by Sound: C60 Fullerene Sonodynamic Treatment of Cancer Cells
- The acoustic pressure waves of ultrasound (US) not only penetrate biological tissues deeper than light, but they also generate light emission, termed sonoluminescence. This promoted the idea of its use as an alternative energy source for photosensitizer excitation. Pristine C60 fullerene (C60), an excellent photosensitizer, was explored in the frame of cancer sonodynamic therapy (SDT). For that purpose, we analyzed C60 effects on human cervix carcinoma HeLa cells in combination with a low-intensity US treatment. The time-dependent accumulation of C60 in HeLa cells reached its maximum at 24 h (800 ± 66 ng/106 cells). Half of extranuclear C60 is localized within mitochondria. The efficiency of the C60 nanostructure’s sonoexcitation with 1 MHz US was tested with cell-based assays. A significant proapoptotic sonotoxic effect of C60 was found for HeLa cells. C60′s ability to induce apoptosis of carcinoma cells after sonoexcitation with US provides a promising novel approach for cancer treatment.
| URN: | urn:nbn:de:kobv:526-opus4-16877 |
|---|---|
| Publisher DOI: | https://doi.org/10.3390/ijms24021020 |
| Author: | Aleksandar RadivoievychORCiD, Benjamin Kolp, Sergii GrebinykORCiD, Svitlana PrylutskaORCiD, Uwe RitterORCiD, Oliver ZolkORCiD, Jörn GlöklerORCiD, Marcus FrohmeORCiDGND, Anna GrebinykORCiD |
| ISSN: | 1422-0067 |
| Parent Title (English): | International Journal of Molecular Sciences |
| Document Type: | Article |
| Language: | English |
| Year of Publication: | 2023 |
| Volume: | 24 |
| Issue: | 2 |
| Article Number: | 1020 |
| Publisher: | MDPI |
| Publishing Institution: | Technische Hochschule Wildau |
| Tag: | C60 fullerene; HeLa cells; apoptosis; sonodynamic therapy; ultrasound |
| Source: | Radivoievych, A.; Kolp, B.; Grebinyk, S.; Prylutska, S.; Ritter, U.; Zolk, O.; Glökler, J.; Frohme, M.; Grebinyk, A. Silent Death by Sound: C60 Fullerene Sonodynamic Treatment of Cancer Cells. Int. J. Mol. Sci. 2023, 24, 1020. https://doi.org/10.3390/ijms24021020 |
| Faculties an central facilities: | Fachbereich Ingenieur- und Naturwissenschaften |
| Dewey Decimal Classification: | 5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie |
| 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 616 Krankheiten | |
| Funding: | Publikationsfonds der TH Wildau |
| Licence (German): | Creative Commons - CC BY - Namensnennung 4.0 International |
| Release Date: | 2023/01/09 |


