Surface Plasmon Resonance (SPR) Spectroscopy and Photonic Integrated Circuit (PIC) Biosensors: A Comparative Review

  • Label-free direct-optical biosensors such as surface-plasmon resonance (SPR) spectroscopy has become a gold standard in biochemical analytics in centralized laboratories. Biosensors based on photonic integrated circuits (PIC) are based on the same physical sensing mechanism: evanescent field sensing. PIC-based biosensors can play an important role in healthcare, especially for point-of-care diagnostics, if challenges for a transfer from research laboratory to industrial applications can be overcome. Research is at this threshold, which presents a great opportunity for innovative on-site analyses in the health and environmental sectors. A deeper understanding of the innovative PIC technology is possible by comparing it with the well-established SPR spectroscopy. In this work, we shortly introduce both technologies and reveal similarities and differences. Further, we review some latest advances and compare both technologies in terms of surface functionalization and sensor performance.

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Metadaten
Author:Patrick SteglichORCiD, Giulia Lecci, Andreas MaiORCiD
URN:urn:nbn:de:kobv:526-opus4-16018
DOI (Version of Record):https://doi.org/10.3390/s22082901
ISSN:1424-8220
Parent Title (English):Sensors
Publisher:MDPI
Document Type:Article
Language:English
Year of Publication:2022
Publishing Institution:Technische Hochschule Wildau
Release Date:2022/04/12
Tag:biosensor; label-free detection; photonic integrated circuits; surface functionalization; surface-plasmon resonance
Volume:22
Issue:8
Article Number:2901
Source:Steglich P, Lecci G, Mai A. Surface Plasmon Resonance (SPR) Spectroscopy and Photonic Integrated Circuit (PIC) Biosensors: A Comparative Review. Sensors. 2022; 22(8):2901. https://doi.org/10.3390/s22082901
Faculties an central facilities:Fachbereich Ingenieur- und Naturwissenschaften
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 62 Ingenieurwissenschaften / 621 Angewandte Physik
Funding:Publikationsfonds der TH Wildau
Licence (German):Creative Commons - CC BY - Namensnennung 4.0 International
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