Surface Plasmon Resonance (SPR) Spectroscopy and Photonic Integrated Circuit (PIC) Biosensors: A Comparative Review
- Label-free direct-optical biosensors such as surface-plasmon resonance (SPR) spectroscopy has become a gold standard in biochemical analytics in centralized laboratories. Biosensors based on photonic integrated circuits (PIC) are based on the same physical sensing mechanism: evanescent field sensing. PIC-based biosensors can play an important role in healthcare, especially for point-of-care diagnostics, if challenges for a transfer from research laboratory to industrial applications can be overcome. Research is at this threshold, which presents a great opportunity for innovative on-site analyses in the health and environmental sectors. A deeper understanding of the innovative PIC technology is possible by comparing it with the well-established SPR spectroscopy. In this work, we shortly introduce both technologies and reveal similarities and differences. Further, we review some latest advances and compare both technologies in terms of surface functionalization and sensor performance.
| URN: | urn:nbn:de:kobv:526-opus4-16018 |
|---|---|
| Publisher DOI: | https://doi.org/10.3390/s22082901 |
| Author: | Patrick SteglichORCiD, Giulia LecciORCiD, Andreas MaiORCiD |
| ISSN: | 1424-8220 |
| Parent Title (English): | Sensors |
| Document Type: | Article |
| Language: | English |
| Year of Publication: | 2022 |
| Volume: | 22 |
| Issue: | 8 |
| Article Number: | 2901 |
| Publisher: | MDPI |
| Publishing Institution: | Technische Hochschule Wildau |
| Tag: | biosensor; label-free detection; photonic integrated circuit; surface functionalization; surface plasmon resonance |
| Source: | Steglich P, Lecci G, Mai A. Surface Plasmon Resonance (SPR) Spectroscopy and Photonic Integrated Circuit (PIC) Biosensors: A Comparative Review. Sensors. 2022; 22(8):2901. https://doi.org/10.3390/s22082901 |
| Faculties an central facilities: | Fachbereich Ingenieur- und Naturwissenschaften |
| Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 62 Ingenieurwissenschaften / 621 Angewandte Physik |
| Funding: | Publikationsfonds der TH Wildau |
| Licence (German): | Creative Commons - CC BY - Namensnennung 4.0 International |
| Release Date: | 2022/04/12 |


