The ElonginB/C-Cullin5-SOCS-Box-Complex Is a Potential Biomarker for Growth Hormone Disorders

  • Insulin-like growth factor 1 (IGF-1) is the standard biochemical marker for the diagnosis and treatment control of acromegaly and growth hormone deficiency (GHD). However, its limitations necessitate the screening for new specific and sensitive biomarkers. The elonginB/C-cullin5-SOCS-box-complex (ECS-complex) (an intracellular five-protein complex) is stimulated by circulating growth hormone (GH) and regulates GH receptor levels through a negative feedback loop. It mediates the cells’ sensitivity for GH and therefore, represents a potent new biomarker for those diseases. In this study, individual ECS-complex proteins were measured in whole blood samples of patients with acromegaly (n = 32) or GHD (n = 12) via ELISA and compared to controls. Hierarchical clustering of the results revealed that by combining the three ECS-complex proteins suppressor of cytokine signaling 2 (SOCS2), cullin-5 and ring-box protein 2 (Rbx-2), 93% of patient samples could be separated from controls, despite many patients having a normal IGF-1 or not receiving medical treatment. SOCS2 showed the best individual diagnostic performance with an overall accuracy of 0.93, while the combination of the three proteins correctly identified all patients and controls. This resulted in perfect sensitivity and specificity for all patient groups, which demonstrates potential benefits of the ECS-complex proteins as clinical biomarkers for the diagnostics of GH-related diseases and substantiates their important role in GH metabolism.

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Metadaten
Author:Wilhelm Gossing, Lars Radke, Henrik Biering, Sven Diederich, Knut Mai, Marcus FrohmeORCiDGND
URN:urn:nbn:de:kobv:526-opus4-13802
DOI:https://doi.org/10.3390/biomedicines9020201
ISSN:2227-9059
Parent Title (English):Biomedicines
Publisher:MDPI
Document Type:Article
Language:English
Year of Publication:2021
Date of first Publication:2021/02/17
Publishing Institution:Technische Hochschule Wildau
Release Date:2021/03/17
Tag:SOCS2; acromegaly; biomarker; growth hormone deficiency; liquid biopsies; pituitary
Volume:9
Issue:2
Source:Gossing, W.; Radke, L.; Biering, H.; Diederich, S.; Mai, K.; Frohme, M. The ElonginB/C-Cullin5-SOCS-Box-Complex Is a Potential Biomarker for Growth Hormone Disorders. Biomedicines 2021, 9, 201. https://doi.org/10.3390/biomedicines9020201
Faculties an central facilities:Fachbereich Ingenieur- und Naturwissenschaften
Dewey Decimal Classification:5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie
Funding:Publikationsfonds der TH Wildau
Licence (German):Creative Commons - CC BY - Namensnennung 4.0 International
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