Biomarkers for Liquid Biopsies of Pituitary Neuroendocrine Tumors

  • Pituitary neuroendocrine tumors (PitNET) do not only belong to the most common intracranial neoplasms but seem to be generally more common than has been thought. Minimally invasive liquid biopsies have the potential to improve their early screening efficiency as well as monitor prognosis by facilitating the diagnostic procedures. This review aims to assess the potential of using liquid biopsies of different kinds of biomarker species that have only been obtained from solid pituitary tissues so far. Numerous molecules have been associated with the development of a PitNET, suggesting that it often develops from the cumulative effects of many smaller genetic or epigenetic changes. These minor changes eventually pile up to switch critical molecules into tumor-promoting states, which may be the key regulatory nodes representing the most potent marker substances for a diagnostic test. Drugs targeting these nodes may be superior for the therapeutic outcome and therefore the identification of such pituitary-specific cellular key nodes will help to accelerate their application in medicine. The ongoing genetic degeneration in pituitary adenomas suggests that repeated tumor profiling via liquid biopsies will be necessary for personalized and effective treatment solutions.

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Metadaten
Author:Wilhelm Gossing, Marcus FrohmeORCiDGND, Lars Radke
URN:urn:nbn:de:kobv:526-opus4-13307
DOI:https://doi.org/10.3390/biomedicines8060148
ISSN:2227-9059
Parent Title (English):Biomedicines
Document Type:Article
Language:English
Year of Publication:2020
Publishing Institution:Technische Hochschule Wildau
Release Date:2020/06/30
Volume:8
Issue:6
Source:Gossing, W.; Frohme, M.; Radke, L. Biomarkers for Liquid Biopsies of Pituitary Neuroendocrine Tumors. Biomedicines 2020, 8, 148.
Institutes:Fachbereich Ingenieur- und Naturwissenschaften
Dewey Decimal Classification:5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie
DFG-geförderter Publikationsfonds:DFG-geförderter Publikationsfonds
Licence (German):Creative Commons - CC BY - Namensnennung 4.0 International