TY - JOUR A1 - Bay, Daniyah H. A1 - Busch, Annika A1 - Lisdat, Fred A1 - Iida, Keisuke A1 - Ikebukuro, Kazunori A1 - Nagasawa, Kazuo A1 - Karube, Isao A1 - Yoshida, Wataru T1 - Identification of G-quadruplex structures that possess transcriptional regulating functions in the Dele and Cdc6 CpG islands JF - BMC Molecular Biology N2 - G-quadruplex is a DNA secondary structure that has been shown to play an important role in biological systems. In a previous study, we identified 1998 G-quadruplex-forming sequences using a mouse CpG islands DNA microarray with a fluorescent-labeled G-quadruplex ligand. Among these putative G-quadruplex-forming sequences, G-quadruplex formation was verified for 10 randomly selected sequences by CD spectroscopy and DMS footprinting analysis. In this study, the biological function of the 10 G-quadruplex-forming sequences in the transcriptional regulation has been analyzed using a reporter assay. KW - Cdc6 KW - Dele KW - G-quadruplex KW - transcriptional regulation KW - 7OTD Y1 - 2017 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:526-opus4-9811 SN - 1471-2199 VL - 18 IS - 17 ER -