TY - JOUR A1 - Li, Xiangkun A1 - Amirkhanyan, Zohrab A1 - Grebinyk, Anna A1 - Gross, Matthias A1 - Komar, Yuliia A1 - Riemer, Felix A1 - Asoyan, Aida A1 - Boonpornprasert, Prach A1 - Borchert, Paul A1 - Davtyan, Hakob A1 - Dmytriiev, Dmytro A1 - Frohme, Marcus A1 - Hoffmann, Andreas A1 - Krasilnikov, Mikhail A1 - Loisch, Gregor A1 - Lotfi, Zahra A1 - Müller, Frieder A1 - Schmitz, Michael A1 - Obier, Frank A1 - Oppelt, Anne A1 - Philipp, Sebastian A1 - Richard, Christopher A1 - Vashchenko, Grygorii A1 - Villani, Daniel A1 - Worm, Steven A1 - Stephan, Frank T1 - Demonstration of ultra-high dose rate electron irradiation at FLASHlab@PITZ JF - Physics in Medicine & Biology N2 - Objective. The photo injector test facility at DESY in Zeuthen (PITZ) is building up an R&D platform, known as FLASHlab@PITZ, for systematically studying the FLASH effect in cancer treatment with its high-brightness electron beams, which can provide a uniquely large dose parameter range for radiation experiments. In this paper, we demonstrate the capabilities by experiments with a reduced parameter range on a startup beamline and study the potential performance of the full beamline by simulations. Approach. To measure the dose, Gafchromic films are installed both in front of and after the samples; Monte Carlo simulations are conducted to predict the dose distribution during beam preparation and help understand the dose distribution inside the sample. Plasmid DNA is irradiated under various doses at conventional and ultra-high dose rate (UHDR) to study the DNA damage by radiations. Start-to-end simulations are performed to verify the performance of the full beamline. Main results. On the startup beamline, reproducible irradiation has been established with optimized electron beams and the delivered dose distributions have been measured with Gafchromic films and compared to FLUKA simulations. The functionality of this setup has been further demonstrated in biochemical experiments at conventional dose rate of 0.05 Gy s−1 and UHDR of several 105 Gy s−1 and a varying dose up to 60 Gy, with the UHDR experiments finished within a single RF pulse (less than 1 millisecond); the observed conformation yields of the irradiated plasmid DNA revealed its dose-dependent radiation damage. The upgrade to the full FLASHlab@PITZ beamline is justified by simulations with homogeneous radiation fields generated by both pencil beam scanning and scattering beams. Significance. With the demonstration of UHDR irradiation and the simulated performance of the new beamline, FLASHlab@PITZ will serve as a powerful platform for studying the FLASH effects in cancer treatment. KW - ultra-high dose rate KW - FLASH effect KW - electron beams KW - FLASHlab@PITZ Y1 - 2025 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:526-opus4-20092 VL - 70 IS - 5 PB - Institute of Physics Publishing (IOP) ER - TY - CHAP A1 - Gross, Matthias A1 - Kuhl, Thorsten A1 - Stephan, Frank A1 - Li, Xiangkun A1 - Philipp, Sebastian A1 - Grebinyk, Anna A1 - Khachatryan, Vitali A1 - Qian, Houjun A1 - Aboulbanine, Zakaria A1 - Amirkhanyan, Zohrab A1 - Riemer, Felix A1 - Oppelt, Anne A1 - Krasilnikov, Mikhail ED - Istituto Nazionale Di Fisca Nucleare, T1 - A beam line setup for flash radiation therapy with focused electron beams at the Pitz facility at DESY in Zeuthen: basic concept and dosimetry simulations T2 - IPAC'23 : 14th International Particle Accelerator Conference, 7-12 May 2023, Venice, Italy : proceedings N2 - The aim of this work is to demonstrate the principal possibility to enhance the electron beam dose deposition in the depth of the sample for radiation therapy purposes. Trains of electron bunches of 22 MeV generated at PITZ are focused inside the sample using a dedicated fast deflector and a solenoid magnet. To explore the capabilities of the proposed setup, dose distributions are calculated for multiple electron bunches focused in a single point inside a water phantom. Electron beam focusing produces dose peaks with a tunable maximal dose depth which is interesting for healthy tissue sparing at the surface and enhancing treatment quality. The duration of the full bunch train is 1 ms. During this time interval, the FLASH effect could be efficiently triggered inside the irradiated target volume. Monte Carlo simulations based on the FLUKA code were performed to evaluate the depth dose curves distributions in a water phantom. Using the PITZ electron beam parameters, simulations have shown the possibility to produce a peak dose in water seven times higher than compared to the dose at the surface. Moreover, the RMS size homogeneous area around the maximal dose is approximately 25 mm. Y1 - 2023 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:526-opus4-21132 SP - 5000 EP - 5003 PB - JACoW Publishing ER - TY - CHAP A1 - Gross, Matthias A1 - Hoffmann, Andreas A1 - Georgiev, Georgi A1 - Kuhl, Thorsten A1 - Li, Xiangkun A1 - Oppelt, Anne A1 - Boonpornprasert, Prach A1 - Philipp, Sebastian A1 - Grebinyk, Anna A1 - Vashchenko, Grygorii A1 - Aftab, Namra A1 - Adhikari, Gowri A1 - Richard, Christopher A1 - Stephan, Frank A1 - Khachatryan, Vitali A1 - Riemer, Felix A1 - Krasilnikov, Mikhail A1 - Amirkhanyan, Zohrab ED - Istituto Nazionale Di Fisca Nucleare, T1 - Comparison of measurements and simulation results of dose for the FLASH radiation therapy beamline at PITZ T2 - IPAC'23 : 14th International Particle Accelerator Conference, 7-12 May 2023, Venice, Italy : proceedings N2 - The high-brightness electron beam at the Photo Injector Test facility at DESY in Zeuthen (PITZ) is now also used for FLASHlab@PITZ: an R&D platform for studying radiation biology and the FLASH effect in radiation therapy. The available parameter space of the electron beam with a momentum of 22 MeV/c allows bunch charges from 10 pC up to 5nC, bunch durations of 0.1–60ps, and bunch train lengths up to 1 ms. The number of bunches in the single train can currently be varied between 1 and 1000 bunches, with an upgrade to 4500 foreseen in 2023. Radiation biology studies require accurate dose prediction, therefore Monte Carlo simulations based on the FLUKA code were performed. According to estimations, dose delivery of 0.002 Gy (low charge case 0.1pC) and 10Gy (high charge case 5nC) is possible, if the beam is confined to a circular area with a radius of 5 mm with a lead collimator. For the Monte Carlo simulations, the experimental setup was accurately modeled, including the exit window, lead collimator, etc. Dose measurements were used to compare simulations with experiments. Dose profiles were experimentally measured with Gafchromic films and then compared with Monte Carlo simulations. The first experiments at FLASHlab@PITZ in 2023 have demonstrated flexible dose options for studying the FLASH effect and radiation biology studies. Y1 - 2023 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:526-opus4-21126 SP - 4996 EP - 4999 PB - JACoW Publishing ER -