TY - JOUR A1 - Schneider, Sylvio A1 - Selig, Martina A1 - Keil, Verena A1 - Lehmann, Matthias A1 - Foitzik, Andreas A1 - Casalboni, Mauro A1 - Richetta, Maria T1 - Development of a Smartphone Based Reader for the Quantitative Analysis of Lateral Flow Assays JF - Materials Science Forum N2 - Smartphones are developing into all-purposes devices. In the present work, the employment/application of smartphones as medical devices in home care and point-of-care (POC) diagnostics are investigated in the analysis of Lateral Flow Assays (LFA). A smartphone-based LFA reader was developed for the quantitative analysis of D-Dimer – a biomarker indicating e.g. thrombotic event or danger of embolism.The proof-of-concept has been shown with multiple smartphones in establishing: (I) Optimal dimensions of the LFA cell of 72.11mm distance of smartphone to D-Dimer test leading to a coefficients of variances (CV) between 0.8% and 4.2%. (II) Inter-device investigations: CVs around 13.5%; a limit of detection (LOD) of 100ng/ml (DDU) D-Dimer. (III) Inter-smartphone investigations: CV about 16%, a limit of detection (LOD) at 66.4ng/ml (DDU). (IV) Calibrations: CV and LOD of three smartphones are comparable to the commercial available LFA reader. Further development to put the multiple smartphone-based LFA reader on the market. KW - APP KW - home care KW - lateral flow assay KW - LFA reader KW - point-of-care (POC) KW - quantitative analysis KW - smartphone Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:526-opus4-18688 SN - 0255-5476 SN - 1662-9752 VL - 941 SP - 2522 EP - 2527 PB - Trans Tech Publications ER -