TY - JOUR A1 - Mai, Andreas A1 - Mai, Christian A1 - Steglich, Patrick T1 - From Lab-on-chip to Lab-in-App: Challenges towards silicon photonic biosensors product developments JF - Results in Optics N2 - This work presents and evaluates different approaches of integrated optical sensors based on photonic integrated circuit (PIC) technologies for refractive index sensing. Bottlenecks in the fabrication flow towards an applicable system are discussed that hinder a cost-effective mass-production for disposable sensor chips. As sensor device, a waveguide coupled micro-ring based approach is chosen which is manufactured in an 8” wafer level process. We will show that the co-integration with a reproducible, scalable and low-cost microfluidic interface is the main challenge which needs to be overcome for future application of silicon technology based PIC sensor chips. KW - silicon photonic sensor KW - integrated optical sensor KW - photonic integrated circuit KW - optical ring resonator KW - photonic biosensor KW - refractive index sensing KW - interchangeable sensor chip Y1 - 2022 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:526-opus4-16687 SN - 2666-9501 VL - 9 PB - Elsevier ER - TY - CHAP A1 - Tannenberg, Robert A1 - Paul, Martin A1 - Fünning, Tabea A1 - Schumann, Christoph A1 - Weller, Michael G. A1 - Steglich, Patrick ED - Baldini, Francesco ED - Homola, Jiri ED - Lieberman, Robert A. T1 - Multichannel real-time detection of biomarkers with highly miniaturized photonic microchips T2 - Proceedings of SPIE : Optical Sensors 2025 N2 - The development of novel photonic integrated microchips (PIC) is a promising approach to allow for the convenient detection of key biomarkers in complex matrices through multichannel real-time analysis in a highly compact package. This study reports the successful development and application of a backside released CMOS chip designed for the multichannel real-time detection of biomarkers. Operating at the C-band at approx. 1550 nm, the microchip features three dedicated detection sensors in addition to a reference sensor, enabling simultaneous analysis of multiple biomarkers. The compact and highly miniaturized design of this microchip, with a footprint of just 1 mm², positions it as promising candidate for point-of-care diagnostics and personalized medicine applications. This technology opens a path to transform biomarker detection across various medical fields, offering rapid, reliable, and cost-effective diagnostic solutions. In conclusion, the presented multichannel photonic microchips signify a substantial leap forward in real-time biomarker detection, providing a highly capable platform for future research and clinical applications. KW - photonic biosensor KW - silicon photonics KW - photonic integrated circuit KW - immunosensor KW - biochemical sensor KW - optical biosensor KW - surface functionalization Y1 - 2025 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:526-opus4-20456 VL - 13527 PB - SPIE ER -